STRINGSTRING
SGRA_3889 SGRA_3889 SGRA_3864 SGRA_3864 xseA xseA SGRA_3580 SGRA_3580 SGRA_3579 SGRA_3579 sms sms polA polA phrB-2 phrB-2 dnaE dnaE SGRA_3413 SGRA_3413 hsdR-2 hsdR-2 ligA ligA SGRA_3264 SGRA_3264 holA holA gyrB gyrB recB recB SGRA_3151 SGRA_3151 SGRA_3132 SGRA_3132 SGRA_3008 SGRA_3008 mutL mutL SGRA_2790 SGRA_2790 SGRA_2735 SGRA_2735 dnaB dnaB sprA sprA ruvA ruvA mutS2 mutS2 xthA xthA ruvB ruvB dcm dcm SGRA_2288 SGRA_2288 SGRA_2251 SGRA_2251 mutY mutY SGRA_2155 SGRA_2155 mutS mutS recG recG holB holB recA recA ruvC ruvC dnaN dnaN uvrB uvrB SGRA_1751 SGRA_1751 SGRA_1671 SGRA_1671 recQ-2 recQ-2 parE parE SGRA_1411 SGRA_1411 SGRA_1355 SGRA_1355 uvrC uvrC SGRA_1322 SGRA_1322 dnaX dnaX phrB phrB SGRA_1191 SGRA_1191 SGRA_1184 SGRA_1184 SGRA_1025 SGRA_1025 SGRA_1023 SGRA_1023 recQ recQ SGRA_0949 SGRA_0949 parC parC SGRA_0891 SGRA_0891 topA topA nth nth ung ung priA priA tatD tatD dpx dpx SGRA_0580 SGRA_0580 gyrA gyrA SGRA_0534 SGRA_0534 xerD xerD SGRA_0347 SGRA_0347 nfi nfi SGRA_0305 SGRA_0305 hsdR hsdR cas1 cas1 SGRA_0181 SGRA_0181 SGRA_0118 SGRA_0118 SGRA_0113 SGRA_0113 SGRA_0100 SGRA_0100 uvrD-2 uvrD-2 SGRA_4160 SGRA_4160 ycaJ ycaJ SGRA_4128 SGRA_4128 SGRA_3913 SGRA_3913 hsdR-3 hsdR-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SGRA_3889Transposase, mutator type; COG3328 Transposase and inactivated derivatives. (398 aa)
SGRA_3864Transposase, is4 family protein; COG3666 Transposase and inactivated derivatives. (554 aa)
xseACOG1570 Exonuclease VII, large subunit; Belongs to the XseA family. (399 aa)
SGRA_3580COG3666 Transposase and inactivated derivatives. (282 aa)
SGRA_3579Transposase, is4 family protein; COG3666 Transposase and inactivated derivatives. (236 aa)
smsDNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (464 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (927 aa)
phrB-2COG0415 Deoxyribodipyrimidine photolyase; Belongs to the DNA photolyase family. (445 aa)
dnaECOG0587 DNA polymerase III, alpha subunit. (1176 aa)
SGRA_3413COG1943 Transposase and inactivated derivatives. (142 aa)
hsdR-2COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases. (1132 aa)
ligADNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (710 aa)
SGRA_3264Hypothetical protein. (205 aa)
holACOG1466 DNA polymerase III, delta subunit. (356 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (658 aa)
recBUvrD/REP helicase; COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains). (1091 aa)
SGRA_3151Transposase, mutator type; COG3328 Transposase and inactivated derivatives. (398 aa)
SGRA_3132Transposase, mutator type; COG3328 Transposase and inactivated derivatives. (398 aa)
SGRA_3008Transposase, mutator type; COG3328 Transposase and inactivated derivatives. (398 aa)
mutLDNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (622 aa)
SGRA_2790Hypothetical protein. (1159 aa)
SGRA_2735Transposase, mutator type; COG3328 Transposase and inactivated derivatives. (398 aa)
dnaBPrimary replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (510 aa)
sprAGliding motility protein SprA. (2512 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (203 aa)
mutS2MutS2 family protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (800 aa)
xthAExodeoxyribonuclease III Xth; COG0708 Exonuclease III. (257 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (341 aa)
dcmDNA-cytosine methyltransferase; COG0270 Site-specific DNA methylase. (418 aa)
SGRA_2288ADP-ribosylation/crystallin J1. (393 aa)
SGRA_2251DNA mismatch repair protein MutS domain-containing protein; COG0249 Mismatch repair ATPase (MutS family). (589 aa)
mutYA/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (402 aa)
SGRA_2155Transposase, is4 family protein; COG3666 Transposase and inactivated derivatives. (554 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (884 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (702 aa)
holBCOG2812 DNA polymerase III, gamma/tau subunits. (385 aa)
recArecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (372 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (177 aa)
dnaNDNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (372 aa)
uvrBExcinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (680 aa)
SGRA_1751Hypothetical protein. (256 aa)
SGRA_1671Transposase, mutator type; COG3328 Transposase and inactivated derivatives. (398 aa)
recQ-2COG0514 Superfamily II DNA helicase. (737 aa)
parEDNA topoisomerase IV subunit B; COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. (616 aa)
SGRA_1411Transposase, mutator type; Required for the transposition of the insertion element. (398 aa)
SGRA_1355Smr protein/MutS2; COG1193 Mismatch repair ATPase (MutS family). (365 aa)
uvrCUvrabc system protein c; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (603 aa)
SGRA_1322COG2963 Transposase and inactivated derivatives. (140 aa)
dnaXDNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (593 aa)
phrBCOG0415 Deoxyribodipyrimidine photolyase; Belongs to the DNA photolyase family. (466 aa)
SGRA_1191COG2963 Transposase and inactivated derivatives. (140 aa)
SGRA_1184COG2963 Transposase and inactivated derivatives. (140 aa)
SGRA_1025ATP-dependent DNA ligase. (1056 aa)
SGRA_1023RNA-directed DNA polymerase; COG3344 Retron-type reverse transcriptase. (554 aa)
recQATP-dependent DNA helicase, RecQ family protein; COG0514 Superfamily II DNA helicase. (2930 aa)
SGRA_0949COG1722 Exonuclease VII small subunit. (65 aa)
parCCOG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit. (839 aa)
SGRA_0891Transposase, is4 family protein; COG3666 Transposase and inactivated derivatives. (554 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (876 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (227 aa)
unguracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (226 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (839 aa)
tatDHydrolase, TatD family protein; COG0084 Mg-dependent DNase. (272 aa)
dpxPHP domain protein; COG1796 DNA polymerase IV (family X). (556 aa)
SGRA_0580Hypothetical protein; COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases. (153 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (858 aa)
SGRA_0534Transposase, mutator type; Required for the transposition of the insertion element. (362 aa)
xerDTyrosine recombinase XerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (303 aa)
SGRA_0347COG2963 Transposase and inactivated derivatives. (140 aa)
nfiEndonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (229 aa)
SGRA_0305COG4268 McrBC 5-methylcytosine restriction system component. (408 aa)
hsdRType I site-specific deoxyribonuclease, HsdR family; Subunit R is required for both nuclease and ATPase activities, but not for modification. (936 aa)
cas1CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (321 aa)
SGRA_0181AAA ATPase; COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member. (427 aa)
SGRA_0118Transposase, is4 family protein; COG3666 Transposase and inactivated derivatives. (554 aa)
SGRA_0113COG2963 Transposase and inactivated derivatives. (140 aa)
SGRA_0100COG4268 McrBC 5-methylcytosine restriction system component. (398 aa)
uvrD-2COG0210 Superfamily I DNA and RNA helicases. (759 aa)
SGRA_4160COG2963 Transposase and inactivated derivatives. (140 aa)
ycaJRecombination factor protein RarA; COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase. (424 aa)
SGRA_4128COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases. (1036 aa)
SGRA_3913Transposase, is4 family protein; COG3666 Transposase and inactivated derivatives. (554 aa)
hsdR-3Type I restriction-modification system, R subunit; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1070 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
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