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SGRA_3668 SGRA_3668 glpK glpK uppS uppS SGRA_0363 SGRA_0363 SGRA_0364 SGRA_0364 SGRA_1449 SGRA_1449 thiC thiC thiE thiE thiD thiD thiE-2 thiE-2 thiG thiG SGRA_1471 SGRA_1471 SGRA_1472 SGRA_1472 thiH thiH suhB suhB SGRA_1696 SGRA_1696 cysQ cysQ aroE aroE serA-2 serA-2 SGRA_2010 SGRA_2010 phhB phhB pdxH pdxH pdxA pdxA SGRA_2318 SGRA_2318 SGRA_2361 SGRA_2361 thiL thiL serC serC SGRA_2826 SGRA_2826 pdxJ pdxJ SGRA_2997 SGRA_2997 SGRA_3051 SGRA_3051 SGRA_3198 SGRA_3198 glcD glcD SGRA_3491 SGRA_3491
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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SGRA_3668Galanin; COG0556 Helicase subunit of the DNA excision repair complex. (323 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (494 aa)
uppSUndecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (259 aa)
SGRA_0363Rhodanese domain-containing protein; COG0607 Rhodanese-related sulfurtransferase. (146 aa)
SGRA_0364Rhodanese domain protein; COG0607 Rhodanese-related sulfurtransferase. (103 aa)
SGRA_1449COG2104 Sulfur transfer protein involved in thiamine biosynthesis. (90 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (623 aa)
thiEThiamine-phosphate pyrophosphorylase; COG0352 Thiamine monophosphate synthase. (218 aa)
thiDCOG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (253 aa)
thiE-2Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (218 aa)
thiGThiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa)
SGRA_1471Rhodanese-like domain-containing protein; COG0607 Rhodanese-related sulfurtransferase. (140 aa)
SGRA_1472Rhodanese-like domain-containing protein; COG0607 Rhodanese-related sulfurtransferase. (103 aa)
thiHCOG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes. (381 aa)
suhBInositol monophosphatase; COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family. (268 aa)
SGRA_1696Rhodanese domain protein; COG0607 Rhodanese-related sulfurtransferase. (108 aa)
cysQ3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (263 aa)
aroECOG0169 Shikimate 5-dehydrogenase. (273 aa)
serA-2D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (340 aa)
SGRA_2010Fumarylacetoacetate (FAA) hydrolase; COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway). (204 aa)
phhBTranscriptional coactivator/pterin dehydratase; COG2154 Pterin-4a-carbinolamine dehydratase. (87 aa)
pdxHPyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (223 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. (517 aa)
SGRA_2318Galanin. (302 aa)
SGRA_2361Beta-lactamase domain protein; COG0491 Zn-dependent hydrolases, including glyoxylases. (216 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (342 aa)
serC3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (355 aa)
SGRA_2826Beta-lactamase domain protein; COG0491 Zn-dependent hydrolases, including glyoxylases. (297 aa)
pdxJPyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (239 aa)
SGRA_2997Galanin. (331 aa)
SGRA_3051Fumarylacetoacetase; COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway). (424 aa)
SGRA_3198Hypothetical protein. (306 aa)
glcD(S)-2-hydroxy-acid oxidase; COG0277 FAD/FMN-containing dehydrogenases. (468 aa)
SGRA_3491Thiamine biosynthesis protein (HesA/MoeB/ThiF family protein); COG0607 Rhodanese-related sulfurtransferase. (98 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
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