18 items (Saprospira grandis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pdxA	4-hydroxythreonine-4-phosphate dehydrogenase; COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. (517 aa)
	uppS	Undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (259 aa)
	SGRA_1449	COG2104 Sulfur transfer protein involved in thiamine biosynthesis. (90 aa)
	thiC	Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (623 aa)
	thiE	Thiamine-phosphate pyrophosphorylase; COG0352 Thiamine monophosphate synthase. (218 aa)
	thiD	COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (253 aa)
	thiE-2	Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (218 aa)
	thiG	Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa)
	thiH	COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes. (381 aa)
	serA-2	D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (340 aa)
	phhB	Transcriptional coactivator/pterin dehydratase; COG2154 Pterin-4a-carbinolamine dehydratase. (87 aa)
	pdxH	Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (223 aa)
	SGRA_2318	Galanin. (302 aa)
	thiL	Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (342 aa)
	serC	3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (355 aa)
	pdxJ	Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (239 aa)
	SGRA_2997	Galanin. (331 aa)
	SGRA_3668	Galanin; COG0556 Helicase subunit of the DNA excision repair complex. (323 aa)

Your Current Organism:

Saprospira grandis

NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SGRA_1449	SGRA_2318	SGRA_1449	SGRA_2318	COG2104 Sulfur transfer protein involved in thiamine biosynthesis.	Galanin.	0.656
SGRA_1449	SGRA_2997	SGRA_1449	SGRA_2997	COG2104 Sulfur transfer protein involved in thiamine biosynthesis.	Galanin.	0.656
SGRA_1449	SGRA_3668	SGRA_1449	SGRA_3668	COG2104 Sulfur transfer protein involved in thiamine biosynthesis.	Galanin; COG0556 Helicase subunit of the DNA excision repair complex.	0.656
SGRA_1449	thiC	SGRA_1449	SGRA_1450	COG2104 Sulfur transfer protein involved in thiamine biosynthesis.	Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.	0.952
SGRA_1449	thiD	SGRA_1449	SGRA_1453	COG2104 Sulfur transfer protein involved in thiamine biosynthesis.	COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.	0.844
SGRA_1449	thiE	SGRA_1449	SGRA_1452	COG2104 Sulfur transfer protein involved in thiamine biosynthesis.	Thiamine-phosphate pyrophosphorylase; COG0352 Thiamine monophosphate synthase.	0.862
SGRA_1449	thiE-2	SGRA_1449	SGRA_1454	COG2104 Sulfur transfer protein involved in thiamine biosynthesis.	Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.	0.757
SGRA_1449	thiG	SGRA_1449	SGRA_1455	COG2104 Sulfur transfer protein involved in thiamine biosynthesis.	Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.	0.993
SGRA_1449	thiH	SGRA_1449	SGRA_1650	COG2104 Sulfur transfer protein involved in thiamine biosynthesis.	COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes.	0.819
SGRA_2318	SGRA_1449	SGRA_2318	SGRA_1449	Galanin.	COG2104 Sulfur transfer protein involved in thiamine biosynthesis.	0.656
SGRA_2318	thiC	SGRA_2318	SGRA_1450	Galanin.	Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.	0.671
SGRA_2318	thiD	SGRA_2318	SGRA_1453	Galanin.	COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.	0.586
SGRA_2318	thiG	SGRA_2318	SGRA_1455	Galanin.	Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.	0.674
SGRA_2318	thiH	SGRA_2318	SGRA_1650	Galanin.	COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes.	0.431
SGRA_2997	SGRA_1449	SGRA_2997	SGRA_1449	Galanin.	COG2104 Sulfur transfer protein involved in thiamine biosynthesis.	0.656
SGRA_2997	thiC	SGRA_2997	SGRA_1450	Galanin.	Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.	0.671
SGRA_2997	thiD	SGRA_2997	SGRA_1453	Galanin.	COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.	0.586
SGRA_2997	thiG	SGRA_2997	SGRA_1455	Galanin.	Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.	0.674
SGRA_2997	thiH	SGRA_2997	SGRA_1650	Galanin.	COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes.	0.431
SGRA_3668	SGRA_1449	SGRA_3668	SGRA_1449	Galanin; COG0556 Helicase subunit of the DNA excision repair complex.	COG2104 Sulfur transfer protein involved in thiamine biosynthesis.	0.656