22 items (Saprospira grandis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	SGRA_3285	TM2 domain-containing protein; COG2314 Predicted membrane protein. (180 aa)
	paaE	phenylacetate-CoA oxygenase/reductase, PaaK subunit; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. (367 aa)
	gcvP	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (975 aa)
	aceF	Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (417 aa)
	folK	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. (162 aa)
	SGRA_2628	COG1428 Deoxynucleoside kinases. (219 aa)
	nrdA	Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (803 aa)
	nrdB	Ribonucleoside-diphosphate reductase small chain; COG0208 Ribonucleotide reductase, beta subunit. (323 aa)
	SGRA_1051	4Fe-4S ferredoxin, iron-sulfur binding protein; COG1145 Ferredoxin. (118 aa)
	SGRA_1784	TM2 domain-containing protein; COG2314 Predicted membrane protein. (168 aa)
	sucA	COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes. (922 aa)
	SGRA_4165	TM2 domain containing protein; COG2314 Predicted membrane protein. (149 aa)
	SGRA_4167	TM2 domain containing protein; COG2314 Predicted membrane protein. (151 aa)
	glpA	COG0578 Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (554 aa)
	SGRA_3753	TM2 domain containing protein; COG2314 Predicted membrane protein. (123 aa)
	SGRA_3733	COG1428 Deoxynucleoside kinases. (210 aa)
	sucB-2	Catalytic domain of components of various dehydrogenase complexes; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (441 aa)
	gpsA	COG0240 Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (348 aa)
	gcvH	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
	pdhB	Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (328 aa)
	sucB	2-oxoglutarate dehydrogenase, e2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (420 aa)
	ahpD	Alkylhydroperoxidase like protein, AhpD family; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. (192 aa)

Your Current Organism:

Saprospira grandis

NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SGRA_1051	SGRA_2628	SGRA_1051	SGRA_2628	4Fe-4S ferredoxin, iron-sulfur binding protein; COG1145 Ferredoxin.	COG1428 Deoxynucleoside kinases.	0.858
SGRA_1051	SGRA_3733	SGRA_1051	SGRA_3733	4Fe-4S ferredoxin, iron-sulfur binding protein; COG1145 Ferredoxin.	COG1428 Deoxynucleoside kinases.	0.858
SGRA_1051	paaE	SGRA_1051	SGRA_3262	4Fe-4S ferredoxin, iron-sulfur binding protein; COG1145 Ferredoxin.	phenylacetate-CoA oxygenase/reductase, PaaK subunit; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1.	0.735
SGRA_2628	SGRA_1051	SGRA_2628	SGRA_1051	COG1428 Deoxynucleoside kinases.	4Fe-4S ferredoxin, iron-sulfur binding protein; COG1145 Ferredoxin.	0.858
SGRA_2628	folK	SGRA_2628	SGRA_2627	COG1428 Deoxynucleoside kinases.	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase.	0.975
SGRA_3733	SGRA_1051	SGRA_3733	SGRA_1051	COG1428 Deoxynucleoside kinases.	4Fe-4S ferredoxin, iron-sulfur binding protein; COG1145 Ferredoxin.	0.858
SGRA_3733	folK	SGRA_3733	SGRA_2627	COG1428 Deoxynucleoside kinases.	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase.	0.904
SGRA_4165	SGRA_4167	SGRA_4165	SGRA_4167	TM2 domain containing protein; COG2314 Predicted membrane protein.	TM2 domain containing protein; COG2314 Predicted membrane protein.	0.450
SGRA_4167	SGRA_4165	SGRA_4167	SGRA_4165	TM2 domain containing protein; COG2314 Predicted membrane protein.	TM2 domain containing protein; COG2314 Predicted membrane protein.	0.450
aceF	gcvH	SGRA_3078	SGRA_2957	Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.627
aceF	gcvP	SGRA_3078	SGRA_3183	Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	0.532
aceF	pdhB	SGRA_3078	SGRA_2542	Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.998
aceF	sucA	SGRA_3078	SGRA_1865	Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes.	0.954
folK	SGRA_2628	SGRA_2627	SGRA_2628	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase.	COG1428 Deoxynucleoside kinases.	0.975
folK	SGRA_3733	SGRA_2627	SGRA_3733	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase.	COG1428 Deoxynucleoside kinases.	0.904
gcvH	aceF	SGRA_2957	SGRA_3078	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.627
gcvH	gcvP	SGRA_2957	SGRA_3183	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	0.999
gcvH	pdhB	SGRA_2957	SGRA_2542	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.524
gcvH	sucA	SGRA_2957	SGRA_1865	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes.	0.751
gcvH	sucB	SGRA_2957	SGRA_2666	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	2-oxoglutarate dehydrogenase, e2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).	0.627