node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SGRA_0122 | folA | SGRA_0122 | SGRA_3126 | COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.912 |
SGRA_0122 | folB | SGRA_0122 | SGRA_3128 | COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.579 |
SGRA_0122 | folE | SGRA_0122 | SGRA_3353 | COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | COG0302 GTP cyclohydrolase I. | 0.579 |
SGRA_0122 | folK | SGRA_0122 | SGRA_2627 | COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. | 0.930 |
SGRA_0122 | folP | SGRA_0122 | SGRA_2942 | COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.997 |
SGRA_0122 | ribBA | SGRA_0122 | SGRA_0862 | COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Gtp cyclohydrolase ii; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.422 |
folA | SGRA_0122 | SGRA_3126 | SGRA_0122 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.912 |
folA | folB | SGRA_3126 | SGRA_3128 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.424 |
folA | phhA | SGRA_3126 | SGRA_1091 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | COG3186 Phenylalanine-4-hydroxylase. | 0.900 |
folB | SGRA_0122 | SGRA_3128 | SGRA_0122 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.579 |
folB | folA | SGRA_3128 | SGRA_3126 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.424 |
folB | folE | SGRA_3128 | SGRA_3353 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | COG0302 GTP cyclohydrolase I. | 0.966 |
folB | folK | SGRA_3128 | SGRA_2627 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. | 0.997 |
folB | folP | SGRA_3128 | SGRA_2942 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.997 |
folB | phoD | SGRA_3128 | SGRA_0894 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | COG3540 Phosphodiesterase/alkaline phosphatase D. | 0.916 |
folB | ribBA | SGRA_3128 | SGRA_0862 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Gtp cyclohydrolase ii; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.465 |
folE | SGRA_0122 | SGRA_3353 | SGRA_0122 | COG0302 GTP cyclohydrolase I. | COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.579 |
folE | folB | SGRA_3353 | SGRA_3128 | COG0302 GTP cyclohydrolase I. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.966 |
folE | folK | SGRA_3353 | SGRA_2627 | COG0302 GTP cyclohydrolase I. | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. | 0.984 |
folE | folP | SGRA_3353 | SGRA_2942 | COG0302 GTP cyclohydrolase I. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.981 |