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| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (435 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (262 aa) |
| | fbaB | COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes. (350 aa) |
| | ribE | COG0307 Riboflavin synthase alpha chain. (198 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (271 aa) |
| | atoB | acetoacetyl-CoA thiolase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa) |
| | uppS | Undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (259 aa) |
| | gcvT | Glycine cleavage system aminomethyltransferase T; The glycine cleavage system catalyzes the degradation of glycine. (368 aa) |
| | pccB | COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (501 aa) |
| | rpiB | COG0698 Ribose 5-phosphate isomerase RpiB. (149 aa) |
| | fabD | COG0331 (acyl-carrier-protein) S-malonyltransferase. (293 aa) |
| | plsB | COG2937 Glycerol-3-phosphate O-acyltransferase. (579 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (340 aa) |
| | SGRA_0550 | COG0436 Aspartate/tyrosine/aromatic aminotransferase. (373 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (537 aa) |
| | SGRA_0564 | Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. (315 aa) |
| | serA | COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (317 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (115 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (192 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (283 aa) |
| | icd | COG0473 Isocitrate/isopropylmalate dehydrogenase. (481 aa) |
| | lpd | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (472 aa) |
| | SGRA_0746 | Putative zinc-type alcohol dehydrogenase-like protein; COG1064 Zn-dependent alcohol dehydrogenases. (335 aa) |
| | mqnD | Hypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (273 aa) |
| | ltaA | COG2008 Threonine aldolase. (338 aa) |
| | atoB-2 | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa) |
| | ribBA | Gtp cyclohydrolase ii; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (415 aa) |
| | rfbD | Putative dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (292 aa) |
| | rfbC | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (181 aa) |
| | ubiE | Demethylmenaquinone methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). (250 aa) |
| | katE | COG0753 Catalase; Belongs to the catalase family. (504 aa) |
| | mdh | Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (374 aa) |
| | SGRA_0982 | COG0686 Alanine dehydrogenase. (403 aa) |
| | hemN | Oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (349 aa) |
| | fbp | COG0158 Fructose-1,6-bisphosphatase. (327 aa) |
| | ubiX | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (191 aa) |
| | crtR | Beta-carotene hydroxylase. (154 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (418 aa) |
| | gapA | COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (495 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (417 aa) |
| | SGRA_1194 | Amidohydrolase; COG0402 Cytosine deaminase and related metal-dependent hydrolases. (393 aa) |
| | mvaD | COG3407 Mevalonate pyrophosphate decarboxylase. (347 aa) |
| | mtnN | Purine or other phosphorylase family 1; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (227 aa) |
| | SGRA_1245 | Alcohol dehydrogenase zinc-binding domain protein; COG1064 Zn-dependent alcohol dehydrogenases. (350 aa) |
| | SGRA_1247 | Phosphoglycerate mutase family protein; COG0406 Fructose-2,6-bisphosphatase. (170 aa) |
| | SGRA_1249 | O-methyltransferase family 2; COG0500 SAM-dependent methyltransferases. (323 aa) |
| | talA | Putative translaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (218 aa) |
| | pdhA | Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (335 aa) |
| | mqnC | Radical SAM domain protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (380 aa) |
| | SGRA_1352 | COG3457 Predicted amino acid racemase. (358 aa) |
| | SGRA_1373 | COG1981 Predicted membrane protein. (188 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (265 aa) |
| | sdaA | COG1171 Threonine dehydratase. (301 aa) |
| | ubiA | COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases; Belongs to the UbiA prenyltransferase family. (285 aa) |
| | cyoE | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (277 aa) |
| | SGRA_1519 | 3-demethylubiquinone-9 3-methyltransferase; COG0500 SAM-dependent methyltransferases. (216 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (320 aa) |
| | SGRA_1551 | O-methyltransferase family 3; COG4122 Predicted O-methyltransferase. (214 aa) |
| | SGRA_1579 | Formyl transferase domain protein; COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. (226 aa) |
| | fumC | Fumarate hydratase, class ii; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa) |
| | suhB | Inositol monophosphatase; COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family. (268 aa) |
| | hemD | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (262 aa) |
| | sdaA-2 | COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (482 aa) |
| | aroE | COG0169 Shikimate 5-dehydrogenase. (273 aa) |
| | rfbB | COG1088 dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (351 aa) |
| | rfbB-2 | dTDP-glucose 4,6-dehydratase, NAD-dependent epimerase/dehydratase-related protein; COG0451 Nucleoside-diphosphate-sugar epimerases. (310 aa) |
| | ubiD | UbiD family decarboxylase; COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases; Belongs to the UbiD family. (610 aa) |
| | sucA | COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes. (922 aa) |
| | manC | COG0836 Mannose-1-phosphate guanylyltransferase. (364 aa) |
| | SGRA_1893 | COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (506 aa) |
| | serA-2 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (340 aa) |
| | SGRA_1936 | 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. (665 aa) |
| | SGRA_1937 | COG0506 Proline dehydrogenase. (362 aa) |
| | pfk | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (325 aa) |
| | sucD | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa) |
| | cdsA | Phosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. (286 aa) |
| | thrB | COG0083 Homoserine kinase. (303 aa) |
| | SGRA_2036 | Cytochrome oxidase assembly; COG1612 Uncharacterized protein required for cytochrome oxidase assembly. (383 aa) |
| | tktA | COG3959 Transketolase, N-terminal subunit. (281 aa) |
| | tktA-2 | COG3958 Transketolase, C-terminal subunit. (317 aa) |
| | SGRA_2083 | Polyprenyl synthetase; COG0142 Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (328 aa) |
| | fabI-2 | COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH). (294 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (413 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. (241 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (510 aa) |
| | SGRA_2249 | COG1257 Hydroxymethylglutaryl-CoA reductase. (515 aa) |
| | sdhC | COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. (207 aa) |
| | sdhA | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (667 aa) |
| | sdhB | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit. (257 aa) |
| | punA | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (276 aa) |
| | glgA | COG0297 Glycogen synthase. (271 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (284 aa) |
| | asnB | COG0367 Asparagine synthase (glutamine-hydrolyzing). (635 aa) |
| | pssA | CDP-diacylglycerol-serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (248 aa) |
| | ilvE | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (362 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (358 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (466 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (298 aa) |
| | SGRA_2370 | COG0076 Glutamate decarboxylase and related PLP-dependent proteins. (485 aa) |
| | gltA | COG0372 Citrate synthase; Belongs to the citrate synthase family. (440 aa) |
| | rfbA | Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (289 aa) |
| | SGRA_2469 | COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (517 aa) |
| | serC | 3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (355 aa) |
| | fadA | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (79 aa) |
| | fadJ | 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase. (704 aa) |
| | pyk | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa) |
| | pdhB | Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (328 aa) |
| | SGRA_2550 | Cystathionine beta-synthase; COG0031 Cysteine synthase. (455 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (330 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (149 aa) |
| | metH | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1225 aa) |
| | SGRA_2632 | COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (471 aa) |
| | accB | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (171 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (456 aa) |
| | sucB | 2-oxoglutarate dehydrogenase, e2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (420 aa) |
| | miaA | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (302 aa) |
| | mvaK1 | COG1577 Mevalonate kinase. (296 aa) |
| | icd-2 | COG0538 Isocitrate dehydrogenases. (399 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (175 aa) |
| | SGRA_2872 | Asparaginase/glutaminase; COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D. (173 aa) |
| | fabG | 3-ketoacyl-(acyl-carrier-protein) reductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (233 aa) |
| | hisC | COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. (389 aa) |
| | SGRA_2914 | Squalene/phytoene synthase; COG1562 Phytoene/squalene synthetase. (280 aa) |
| | SGRA_2915 | COG1233 Phytoene dehydrogenase and related proteins. (490 aa) |
| | hmgL | hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases. (276 aa) |
| | gcvH | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa) |
| | gcdH | COG1960 Acyl-CoA dehydrogenases. (405 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (257 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (362 aa) |
| | rfbD-2 | COG1091 dTDP-4-dehydrorhamnose reductase. (295 aa) |
| | aceF | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (417 aa) |
| | rfbA-2 | Nucleotidyl transferase; COG1209 dTDP-glucose pyrophosphorylase. (331 aa) |
| | SGRA_3095 | Riboflavin biosynthesis protein ribd; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (348 aa) |
| | SGRA_3175 | Thioesterase superfamily protein; COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism. (143 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (293 aa) |
| | gcvP | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (975 aa) |
| | surE | 5'(3')-nucleotidase/polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (256 aa) |
| | manB | COG1109 Phosphomannomutase. (463 aa) |
| | glcD | (S)-2-hydroxy-acid oxidase; COG0277 FAD/FMN-containing dehydrogenases. (468 aa) |
| | argH | COG0165 Argininosuccinate lyase. (445 aa) |
| | gpm | Phosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (510 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | manA | Bifunctional phosphoglucose/phosphomannose isomerase; COG0166 Glucose-6-phosphate isomerase. (330 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (342 aa) |
| | SGRA_3396 | 5 nucleotidase deoxy cytosolic type C; COG4502 Uncharacterized protein conserved in bacteria. (149 aa) |
| | lysC | COG0527 Aspartokinases; Belongs to the aspartokinase family. (424 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (174 aa) |
| | SGRA_3436 | hydroxymethylglutaryl-CoA reductase, degradative; COG1257 Hydroxymethylglutaryl-CoA reductase; Belongs to the HMG-CoA reductase family. (460 aa) |
| | idi | Isopentenyl pyrophosphate isomerase; COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases. (341 aa) |
| | acs | Acetyl-coenzyme a synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (633 aa) |
| | aroA-2 | Dahp synthetase i/kdsa; COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase. (373 aa) |
| | rpe | COG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (221 aa) |
| | fabG-2 | 3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (249 aa) |
| | SGRA_3587 | Nad(p)h dehydrogenase (quinone); COG2249 Putative NADPH-quinone reductase (modulator of drug activity B). (193 aa) |
| | gpsA | COG0240 Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (348 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (174 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (378 aa) |
| | acnA | Aconitate hydratase; COG1048 Aconitase A. (759 aa) |
| | sucC | succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (405 aa) |
| | sucB-2 | Catalytic domain of components of various dehydrogenase complexes; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (441 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa) |
| | hemL | Glutamate-1-semialdehyde-2,1-aminomutase; COG0001 Glutamate-1-semialdehyde aminotransferase. (428 aa) |
| | mqnA | Hypothetical protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (256 aa) |
| | mqnE | Radical SAM domain protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (417 aa) |
| | ispB | Polyprenyl synthetase; COG0142 Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (326 aa) |
| | aspB | Aminotransferase class I and II; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (399 aa) |
| | SGRA_3842 | Nucleotidyl transferase; COG1209 dTDP-glucose pyrophosphorylase. (328 aa) |
| | katE-2 | COG0753 Catalase. (576 aa) |
| | dapB | COG0289 Dihydrodipicolinate reductase; Belongs to the DapB family. (242 aa) |
| | SGRA_3932 | Acyl carrier protein. (81 aa) |
| | pgk | COG0126 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (403 aa) |
| | gapA-2 | Glyceraldehyde-3-phosphate dehydrogenase, type I; COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa) |
| | hpt | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (184 aa) |
| | rocF | Arginase/agmatinase/formiminoglutamase; COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family; Belongs to the arginase family. (326 aa) |
| | SGRA_4028 | COG1960 Acyl-CoA dehydrogenases. (613 aa) |
| | rocD | COG4992 Ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa) |
| | asnB-2 | COG0367 Asparagine synthase (glutamine-hydrolyzing). (622 aa) |
| | hemF | COG0408 Coproporphyrinogen III oxidase. (308 aa) |
| | lpd-2 | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (470 aa) |
| | glpA | COG0578 Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (554 aa) |
| | hemB | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (333 aa) |
| | SGRA_4226 | Metallophosphoesterase; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. (319 aa) |
