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glyA glyA fbaB fbaB atoB atoB gcvT gcvT pccB pccB rpiB rpiB pckA pckA gloA gloA serA serA eno eno accD accD icd icd lpd lpd atoB-2 atoB-2 katE katE mdh mdh fbp fbp SGRA_1094 SGRA_1094 gapA gapA crt crt SGRA_1247 SGRA_1247 talA talA pdhA pdhA sdaA sdaA metF metF prsA prsA fumC fumC sdaA-2 sdaA-2 SGRA_1806 SGRA_1806 sucA sucA serA-2 serA-2 pfk pfk sucD sucD tktA tktA tktA-2 tktA-2 sdhC sdhC sdhA sdhA sdhB sdhB gltA gltA serC serC fadN fadN fadJ fadJ pyk pyk pdhB pdhB SGRA_2576 SGRA_2576 folD folD accB accB accC accC sucB sucB icd-2 icd-2 paaH paaH SGRA_2923 SGRA_2923 gcvH gcvH tpiA tpiA aceF aceF gcvP gcvP gpm gpm accA accA manA manA acs acs rpe rpe acnA acnA sucC sucC sucB-2 sucB-2 sfcA sfcA katE-2 katE-2 pgk pgk gapA-2 gapA-2 lpd-2 lpd-2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (435 aa)
fbaBCOG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes. (350 aa)
atoBacetoacetyl-CoA thiolase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
gcvTGlycine cleavage system aminomethyltransferase T; The glycine cleavage system catalyzes the degradation of glycine. (368 aa)
pccBCOG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (501 aa)
rpiBCOG0698 Ribose 5-phosphate isomerase RpiB. (149 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (537 aa)
gloAmethylmalonyl-CoA epimerase; COG0346 Lactoylglutathione lyase and related lyases. (133 aa)
serACOG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (317 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (283 aa)
icdCOG0473 Isocitrate/isopropylmalate dehydrogenase. (481 aa)
lpdCOG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (472 aa)
atoB-2COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
katECOG0753 Catalase; Belongs to the catalase family. (504 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (374 aa)
fbpCOG0158 Fructose-1,6-bisphosphatase. (327 aa)
SGRA_1094Hypothetical protein; COG0247 Fe-S oxidoreductase. (268 aa)
gapACOG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (495 aa)
crtCOG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
SGRA_1247Phosphoglycerate mutase family protein; COG0406 Fructose-2,6-bisphosphatase. (170 aa)
talAPutative translaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (218 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (335 aa)
sdaACOG1171 Threonine dehydratase. (301 aa)
metFCOG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (318 aa)
prsARibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (320 aa)
fumCFumarate hydratase, class ii; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
sdaA-2COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (482 aa)
SGRA_1806COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (713 aa)
sucACOG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes. (922 aa)
serA-2D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (340 aa)
pfk6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (325 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
tktACOG3959 Transketolase, N-terminal subunit. (281 aa)
tktA-2COG3958 Transketolase, C-terminal subunit. (317 aa)
sdhCCOG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. (207 aa)
sdhACOG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (667 aa)
sdhBCOG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit. (257 aa)
gltACOG0372 Citrate synthase; Belongs to the citrate synthase family. (440 aa)
serC3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (355 aa)
fadNCOG1250 3-hydroxyacyl-CoA dehydrogenase. (787 aa)
fadJ3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase. (704 aa)
pykCOG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa)
pdhBTransketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (328 aa)
SGRA_2576COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (361 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa)
accBBiotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (171 aa)
accCacetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (456 aa)
sucB2-oxoglutarate dehydrogenase, e2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (420 aa)
icd-2COG0538 Isocitrate dehydrogenases. (399 aa)
paaHCOG1250 3-hydroxyacyl-CoA dehydrogenase. (296 aa)
SGRA_2923COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (473 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (257 aa)
aceFPyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (417 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (975 aa)
gpmPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (510 aa)
accAacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa)
manABifunctional phosphoglucose/phosphomannose isomerase; COG0166 Glucose-6-phosphate isomerase. (330 aa)
acsAcetyl-coenzyme a synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (633 aa)
rpeCOG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (221 aa)
acnAAconitate hydratase; COG1048 Aconitase A. (759 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (405 aa)
sucB-2Catalytic domain of components of various dehydrogenase complexes; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (441 aa)
sfcAMalate dehydrogenase; COG0281 Malic enzyme. (403 aa)
katE-2COG0753 Catalase. (576 aa)
pgkCOG0126 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (403 aa)
gapA-2Glyceraldehyde-3-phosphate dehydrogenase, type I; COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
lpd-2COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (470 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
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