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glyA glyA proC proC fbaB fbaB rpiB rpiB SGRA_0550 SGRA_0550 glnA glnA serA serA eno eno icd icd ltaA ltaA SGRA_0982 SGRA_0982 aroA aroA phhA phhA gapA gapA metK metK SGRA_1247 SGRA_1247 talA talA dapF dapF sdaA sdaA prsA prsA sdaA-2 sdaA-2 aroE aroE serA-2 serA-2 pfk pfk SGRA_2022 SGRA_2022 thrB thrB tktA tktA tktA-2 tktA-2 dapD dapD lysA lysA hisA hisA asnB asnB ilvE ilvE aroC aroC gltA gltA serC serC pyk pyk SGRA_2550 SGRA_2550 asd asd aroQ aroQ metH metH icd-2 icd-2 hisC hisC tpiA tpiA aroB aroB argH argH gpm gpm dapA dapA lysC lysC aroK aroK aroA-2 aroA-2 rpe rpe acnA acnA aspB aspB dapB dapB pgk pgk gapA-2 gapA-2 rocF rocF asnB-2 asnB-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (435 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (262 aa)
fbaBCOG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes. (350 aa)
rpiBCOG0698 Ribose 5-phosphate isomerase RpiB. (149 aa)
SGRA_0550COG0436 Aspartate/tyrosine/aromatic aminotransferase. (373 aa)
glnACOG3968 Uncharacterized protein related to glutamine synthetase. (722 aa)
serACOG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (317 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
icdCOG0473 Isocitrate/isopropylmalate dehydrogenase. (481 aa)
ltaACOG2008 Threonine aldolase. (338 aa)
SGRA_0982COG0686 Alanine dehydrogenase. (403 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (418 aa)
phhACOG3186 Phenylalanine-4-hydroxylase. (245 aa)
gapACOG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (495 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (417 aa)
SGRA_1247Phosphoglycerate mutase family protein; COG0406 Fructose-2,6-bisphosphatase. (170 aa)
talAPutative translaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (218 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (265 aa)
sdaACOG1171 Threonine dehydratase. (301 aa)
prsARibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (320 aa)
sdaA-2COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (482 aa)
aroECOG0169 Shikimate 5-dehydrogenase. (273 aa)
serA-2D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (340 aa)
pfk6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (325 aa)
SGRA_2022COG0031 Cysteine synthase. (313 aa)
thrBCOG0083 Homoserine kinase. (303 aa)
tktACOG3959 Transketolase, N-terminal subunit. (281 aa)
tktA-2COG3958 Transketolase, C-terminal subunit. (317 aa)
dapDCOG2171 Tetrahydrodipicolinate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (271 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (413 aa)
hisA1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. (241 aa)
asnBCOG0367 Asparagine synthase (glutamine-hydrolyzing). (635 aa)
ilvECOG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (362 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (358 aa)
gltACOG0372 Citrate synthase; Belongs to the citrate synthase family. (440 aa)
serC3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (355 aa)
pykCOG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa)
SGRA_2550Cystathionine beta-synthase; COG0031 Cysteine synthase. (455 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (330 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (149 aa)
metHB12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1225 aa)
icd-2COG0538 Isocitrate dehydrogenases. (399 aa)
hisCCOG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. (389 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (257 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (362 aa)
argHCOG0165 Argininosuccinate lyase. (445 aa)
gpmPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (510 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa)
lysCCOG0527 Aspartokinases; Belongs to the aspartokinase family. (424 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (174 aa)
aroA-2Dahp synthetase i/kdsa; COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase. (373 aa)
rpeCOG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (221 aa)
acnAAconitate hydratase; COG1048 Aconitase A. (759 aa)
aspBAminotransferase class I and II; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (399 aa)
dapBCOG0289 Dihydrodipicolinate reductase; Belongs to the DapB family. (242 aa)
pgkCOG0126 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (403 aa)
gapA-2Glyceraldehyde-3-phosphate dehydrogenase, type I; COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
rocFArginase/agmatinase/formiminoglutamase; COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family; Belongs to the arginase family. (326 aa)
asnB-2COG0367 Asparagine synthase (glutamine-hydrolyzing). (622 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
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