18 items (Saprospira grandis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	dnaQ	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases. (267 aa)
	SGRA_0949	COG1722 Exonuclease VII small subunit. (65 aa)
	dnaX	DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (593 aa)
	recJ	COG0608 Single-stranded DNA-specific exonuclease. (564 aa)
	dnaQ-2	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases. (248 aa)
	dnaN	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (372 aa)
	uvrD	COG0210 Superfamily I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily. (1069 aa)
	holB	COG2812 DNA polymerase III, gamma/tau subunits. (385 aa)
	mutS	DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (884 aa)
	ssb	COG0629 Single-stranded DNA-binding protein. (162 aa)
	mutS2	MutS2 family protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (800 aa)
	mutL	DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (622 aa)
	holA	COG1466 DNA polymerase III, delta subunit. (356 aa)
	ligA	DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (710 aa)
	dnaE	COG0587 DNA polymerase III, alpha subunit. (1176 aa)
	SGRA_3455	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases. (206 aa)
	xseA	COG1570 Exonuclease VII, large subunit; Belongs to the XseA family. (399 aa)
	uvrD-2	COG0210 Superfamily I DNA and RNA helicases. (759 aa)

Your Current Organism:

Saprospira grandis

NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SGRA_0949	recJ	SGRA_0949	SGRA_1416	COG1722 Exonuclease VII small subunit.	COG0608 Single-stranded DNA-specific exonuclease.	0.403
SGRA_0949	xseA	SGRA_0949	SGRA_3760	COG1722 Exonuclease VII small subunit.	COG1570 Exonuclease VII, large subunit; Belongs to the XseA family.	0.997
SGRA_3455	dnaE	SGRA_3455	SGRA_3420	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	COG0587 DNA polymerase III, alpha subunit.	0.957
SGRA_3455	dnaN	SGRA_3455	SGRA_1874	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.959
SGRA_3455	dnaQ	SGRA_3455	SGRA_0076	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	0.900
SGRA_3455	dnaQ-2	SGRA_3455	SGRA_1634	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	0.900
SGRA_3455	dnaX	SGRA_3455	SGRA_1265	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.943
SGRA_3455	holA	SGRA_3455	SGRA_3263	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	COG1466 DNA polymerase III, delta subunit.	0.936
SGRA_3455	holB	SGRA_3455	SGRA_2081	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	COG2812 DNA polymerase III, gamma/tau subunits.	0.943
SGRA_3455	uvrD	SGRA_3455	SGRA_1994	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	COG0210 Superfamily I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily.	0.477
dnaE	SGRA_3455	SGRA_3420	SGRA_3455	COG0587 DNA polymerase III, alpha subunit.	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	0.957
dnaE	dnaN	SGRA_3420	SGRA_1874	COG0587 DNA polymerase III, alpha subunit.	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.990
dnaE	dnaQ	SGRA_3420	SGRA_0076	COG0587 DNA polymerase III, alpha subunit.	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	0.957
dnaE	dnaQ-2	SGRA_3420	SGRA_1634	COG0587 DNA polymerase III, alpha subunit.	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	0.957
dnaE	dnaX	SGRA_3420	SGRA_1265	COG0587 DNA polymerase III, alpha subunit.	DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.973
dnaE	holA	SGRA_3420	SGRA_3263	COG0587 DNA polymerase III, alpha subunit.	COG1466 DNA polymerase III, delta subunit.	0.992
dnaE	holB	SGRA_3420	SGRA_2081	COG0587 DNA polymerase III, alpha subunit.	COG2812 DNA polymerase III, gamma/tau subunits.	0.976
dnaE	ssb	SGRA_3420	SGRA_2177	COG0587 DNA polymerase III, alpha subunit.	COG0629 Single-stranded DNA-binding protein.	0.904
dnaE	uvrD	SGRA_3420	SGRA_1994	COG0587 DNA polymerase III, alpha subunit.	COG0210 Superfamily I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily.	0.517
dnaN	SGRA_3455	SGRA_1874	SGRA_3455	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.	0.959