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| | pheA | COG0077 Prephenate dehydratase. (298 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (322 aa) |
| | AET56791.1 | COG0460 Homoserine dehydrogenase. (428 aa) |
| | AET56792.1 | COG4492 ACT domain-containing protein; Belongs to the UPF0735 family. (145 aa) |
| | AET56895.1 | COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family; Belongs to the arginase family. (304 aa) |
| | AET56941.1 | COG0019 Diaminopimelate decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (428 aa) |
| | AET57017.1 | PHP family hydrolase; COG1387 Histidinol phosphatase and related hydrolases of the PHP family; Belongs to the PHP hydrolase family. HisK subfamily. (269 aa) |
| | AET57269.1 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding subunit; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (315 aa) |
| | argH | COG0165 Argininosuccinate lyase. (470 aa) |
| | argG | COG0137 Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (411 aa) |
| | argF | Ornithine carbamoyltransferase (argf); Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (318 aa) |
| | argD | COG4992 Ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (422 aa) |
| | argB | Acetylglutamate kinase (NAG kinase); Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (279 aa) |
| | argJ | Arginine biosynthesis bifunctional protein argJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (408 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase (AGPR); Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (349 aa) |
| | AET57657.1 | Hypothetical protein. (299 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (400 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (772 aa) |
| | AET57852.1 | Nitric-oxide synthase; Catalyzes the production of nitric oxide. Belongs to the NOS family. Bacterial NOS oxygenase subfamily. (374 aa) |
| | mmuM | COG2040 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent). (326 aa) |
| | AET58274.1 | Hypothetical protein; COG1982 Arginine/lysine/ornithine decarboxylases. (527 aa) |
| | AET58324.1 | COG0031 Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (312 aa) |
| | AET58326.1 | COG0512 Anthranilate/para-aminobenzoate synthases component II. (191 aa) |
| | AET58406.1 | COG2508 Regulator of polyketide synthase expression. (382 aa) |
| | hprK | Serine kinase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (g [...] (312 aa) |
| | lgt | Prolipoprotein diacylglyceryl transferase (spore germination protein gerF); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (352 aa) |
| | AET58410.1 | Pyrophosphatase ppaX; COG0546 Predicted phosphatases. (217 aa) |
| | AET58411.1 | COG0110 Acetyltransferase (isoleucine patch superfamily). (166 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (401 aa) |
| | hisG | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (214 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa) |
| | hisB | COG0131 Imidazoleglycerol-phosphate dehydratase. (202 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (209 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. (243 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF (IGP synthase cyclase subunit); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | hisI | Histidine biosynthesis bifunctional protein hisIE; COG0139 Phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. (246 aa) |
| | AET58427.1 | Histidinol-phosphatase; COG1387 Histidinol phosphatase and related hydrolases of the PHP family; Belongs to the PHP hydrolase family. HisK subfamily. (274 aa) |
| | dapA | Hypothetical protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa) |
| | AET58797.1 | COG2873 O-acetylhomoserine sulfhydrylase. (430 aa) |
| | luxS | S-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (153 aa) |
| | AET59019.1 | UPF0067 protein yebR; COG1956 GAF domain-containing protein. (159 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (296 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (254 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (190 aa) |
| | AET59242.1 | COG0031 Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (307 aa) |
| | AET59361.1 | COG0549 Carbamate kinase; Belongs to the carbamate kinase family. (297 aa) |
| | AET59422.1 | Bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; COG1605 Chorismate mutase. (361 aa) |
| | metAA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (305 aa) |
| | AET59880.1 | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (394 aa) |
| | AET59881.1 | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (392 aa) |
| | serC | 3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (363 aa) |
| | mtnA | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (368 aa) |
| | mtnK | Methylthioribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (407 aa) |
| | AET60062.1 | Hypothetical protein; COG0620 Methionine synthase II (cobalamin-independent). (379 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase); Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (345 aa) |
| | AET60431.1 | Aspartate kinase, monofunctional class; COG0527 Aspartokinases; Belongs to the aspartokinase family. (405 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | AET60617.1 | O-acetylserine lyase; COG0031 Cysteine synthase. (307 aa) |
| | AET60618.1 | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (378 aa) |
| | mtnD | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (180 aa) |
| | AET60762.1 | Methionine synthase I, cobalamin-binding domain protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1146 aa) |
| | AET60925.1 | Aminotransferase class I and II; COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities. (405 aa) |
| | AET61086.1 | Aminotransferase class I and II; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (405 aa) |
| | AET61342.1 | Transaminase mtnE; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (393 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (430 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (288 aa) |
| | mtnW | 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; COG1850 Ribulose 1,5-bisphosphate carboxylase, large subunit; Belongs to the RuBisCO large chain family. (403 aa) |
| | mtnX | 2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphate phosphatase; Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). (225 aa) |
| | mtnB | Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase); Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. (216 aa) |
| | AET61348.1 | Hypothetical protein. (91 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (267 aa) |
| | AET61387.1 | COG0287 Prephenate dehydrogenase. (362 aa) |
| | hisC | Histidinol-phosphate aminotransferase (imidazole acetol-phosphate transaminase); COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (367 aa) |
| | trpA | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa) |
| | trpB | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (398 aa) |
| | trpF | COG0135 Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (228 aa) |
| | trpC | COG0134 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (264 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (348 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (516 aa) |
| | AET61395.1 | Chorismate mutase (CM); Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (124 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (364 aa) |
| | aroC | Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (389 aa) |
| | AET61433.1 | COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (530 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (455 aa) |
| | AET61547.1 | COG0527 Aspartokinases; Belongs to the aspartokinase family. (417 aa) |
| | AET61614.1 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain. (630 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (277 aa) |
| | AET61642.1 | MTA/SAH nucleosidase (5'-methylthioadenosine nucleosidase); Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (232 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (430 aa) |
| | AET61656.1 | COG1982 Arginine/lysine/ornithine decarboxylases. (491 aa) |
| | AET61665.1 | COG0547 Anthranilate phosphoribosyltransferase. (357 aa) |
| | ahcY | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (421 aa) |
| | aroE-2 | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (289 aa) |
| | AET61927.1 | COG0436 Aspartate/tyrosine/aromatic aminotransferase. (384 aa) |
| | AET61932.1 | Hypothetical protein; Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate. (378 aa) |
| | dapH | Tetrahydrodipicolinate N-succinyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (237 aa) |
| | AET61991.1 | Aminoglycoside phosphotransferase; COG2334 Putative homoserine kinase type II (protein kinase fold). (335 aa) |
| | AET62065.1 | COG0498 Threonine synthase. (463 aa) |
| | AET62084.1 | Crp family transcriptional regulator; COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases. (229 aa) |
| | AET62085.1 | Putative amino acid kinase; COG0549 Carbamate kinase; Belongs to the carbamate kinase family. (320 aa) |
| | AET62086.1 | Arginine/ornithine antiporter; COG0531 Amino acid transporters. (471 aa) |
| | argF-2 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (332 aa) |
| | arcA | COG2235 Arginine deiminase. (410 aa) |
| | argR-2 | Arginine repressor; Regulates arginine biosynthesis genes. (150 aa) |
