STRINGSTRING
ilvE ilvE AET56859.1 AET56859.1 AET56860.1 AET56860.1 AET57175.1 AET57175.1 AET57260.1 AET57260.1 AET57261.1 AET57261.1 ppc ppc AET57519.1 AET57519.1 AET57902.1 AET57902.1 AET58083.1 AET58083.1 mqo mqo AET58560.1 AET58560.1 AET58577.1 AET58577.1 ldh ldh AET59004.1 AET59004.1 AET59005.1 AET59005.1 leuD leuD AET59007.1 AET59007.1 AET59305.1 AET59305.1 AET59376.1 AET59376.1 AET59383.1 AET59383.1 AET59572.1 AET59572.1 AET59573.1 AET59573.1 AET59574.1 AET59574.1 AET59575.1 AET59575.1 AET59702.1 AET59702.1 AET59766.1 AET59766.1 AET59845.1 AET59845.1 AET59846.1 AET59846.1 ilvC ilvC leuA leuA leuB leuB AET59982.1 AET59982.1 mdh mdh AET60155.1 AET60155.1 AET60455.1 AET60455.1 AET60558.1 AET60558.1 AET60559.1 AET60559.1 AET60560.1 AET60560.1 AET60564.1 AET60564.1 ldh-2 ldh-2 leuA-2 leuA-2 fumC fumC AET60918.1 AET60918.1 AET61019.1 AET61019.1 AET61184.1 AET61184.1 leuD-2 leuD-2 leuC leuC ackA ackA AET61357.1 AET61357.1 AET61360.1 AET61360.1 AET61456.1 AET61456.1 AET61457.1 AET61457.1 AET61562.1 AET61562.1 AET61563.1 AET61563.1 AET61564.1 AET61564.1 AET61640.1 AET61640.1 AET61669.1 AET61669.1 AET61833.1 AET61833.1 AET61999.1 AET61999.1 AET62057.1 AET62057.1 ilvD ilvD AET62277.1 AET62277.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ilvEBranched-chain-amino acid aminotransferase (transaminase B); Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (294 aa)
AET56859.1Malate dehydrogenase; COG0281 Malic enzyme. (573 aa)
AET56860.1Auxin efflux carrier (AEC) family transporter; COG0679 Predicted permeases. (317 aa)
AET57175.1COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. (333 aa)
AET57260.1COG1024 Enoyl-CoA hydratase/carnithine racemase. (278 aa)
AET57261.1COG1024 Enoyl-CoA hydratase/carnithine racemase. (279 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (930 aa)
AET57519.1Malate dehydrogenase; COG0281 Malic enzyme. (566 aa)
AET57902.1Protein yhdH; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. (335 aa)
AET58083.1Acyl-CoA dehydrogenase type 2 domain-containing protein; COG1960 Acyl-CoA dehydrogenases. (394 aa)
mqoMalate:quinone oxidoreductase; COG0579 Predicted dehydrogenase. (499 aa)
AET58560.1Pyruvate phosphate dikinase; COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (890 aa)
AET58577.1COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (471 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. (318 aa)
AET59004.13-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (366 aa)
AET59005.1COG0065 3-isopropylmalate dehydratase large subunit. (381 aa)
leuD3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (165 aa)
AET59007.1COG0065 3-isopropylmalate dehydratase large subunit. (417 aa)
AET59305.1MaoC like domain protein; COG2030 Acyl dehydratase. (141 aa)
AET59376.1COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. (378 aa)
AET59383.1COG0281 Malic enzyme. (467 aa)
AET59572.13-ketoacid-coenzyme a transferase1; COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit. (218 aa)
AET59573.1COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit. (221 aa)
AET59574.1COG4689 Acetoacetate decarboxylase. (246 aa)
AET59575.1COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
AET59702.1COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. (299 aa)
AET59766.1Malate dehydrogenase (oxaloacetate-decarboxylating); COG0281 Malic enzyme. (472 aa)
AET59845.1Acetolactate synthase large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. (581 aa)
AET59846.1COG0440 Acetolactate synthase, small (regulatory) subunit. (161 aa)
ilvCKetol-acid reductoisomerase 2; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (513 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (358 aa)
AET59982.1COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (476 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (313 aa)
AET60155.1Putative alpha-isopropylmalate/homocitrate synthase family transferase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. (538 aa)
AET60455.1Propanediol utilization phosphotransacylase; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (190 aa)
AET60558.1COG3527 Alpha-acetolactate decarboxylase. (248 aa)
AET60559.1Acetolactate synthase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (562 aa)
AET60560.1Hypothetical protein. (84 aa)
AET60564.1Pyruvate dehydrogenase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (574 aa)
ldh-2L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (309 aa)
leuA-22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (514 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (462 aa)
AET60918.1Oxalate decarboxylase; COG2140 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes. (388 aa)
AET61019.1Malic protein NAD-binding protein; COG0281 Malic enzyme. (475 aa)
AET61184.1Acetyl-coenzyme A synthetase (acetate--CoA ligase); COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (529 aa)
leuD-23-isopropylmalate dehydratase small subunit (Isopropylmalate isomerase); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa)
ackAAcetate kinase (acetokinase); Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
AET61357.1COG1250 3-hydroxyacyl-CoA dehydrogenase. (290 aa)
AET61360.1Acetoin reductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (166 aa)
AET61456.1COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit. (762 aa)
AET61457.1COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit. (337 aa)
AET61562.1Pyruvate formate-lyase activating enzyme (PFL-activating enzyme); Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (252 aa)
AET61563.1Formate acetyltransferase 1 (pyruvate formate-lyase 1); COG1882 Pyruvate-formate lyase. (753 aa)
AET61564.1Bifunctional acetaldehyde-CoA/alcohol dehydrogenase; COG1012 NAD-dependent aldehyde dehydrogenases; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (870 aa)
AET61640.1COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (571 aa)
AET61669.1Malate dehydrogenase; COG0281 Malic enzyme. (572 aa)
AET61833.1Malate dehydrogenase (oxaloacetate-decarboxylating); COG0281 Malic enzyme. (401 aa)
AET61999.1COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (337 aa)
AET62057.1COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (350 aa)
ilvDCOG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (556 aa)
AET62277.1COG0281 Malic enzyme. (390 aa)
Your Current Organism:
Paenibacillus terrae
NCBI taxonomy Id: 985665
Other names: P. terrae HPL-003, Paenibacillus sp. HPL-003, Paenibacillus terrae HPL-003, Paenibacillus terrae str. HPL-003, Paenibacillus terrae strain HPL-003
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