(46 nodes) Organic acid catabolic process network (Paenibacillus terrae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	AET60540.1	6-phosphogluconate dehydrogenase-like protein; COG1023 Predicted 6-phosphogluconate dehydrogenase. (297 aa)
	AET60180.1	Amidohydrolase; COG1228 Imidazolonepropionase and related amidohydrolases. (389 aa)
	AET60124.1	Fumarylacetoacetate hydrolase domain containing protein 1; COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway). (207 aa)
	AET59925.1	COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold. (529 aa)
	AET59702.1	COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. (299 aa)
	AET59575.1	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
	AET59573.1	COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit. (221 aa)
	AET59572.1	3-ketoacid-coenzyme a transferase1; COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit. (218 aa)
	AET59518.1	Beta-lactamase domain protein; COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold; Belongs to the UPF0173 family. (227 aa)
	AET59461.1	Beta-lactamase domain protein; COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold. (250 aa)
	AET59401.1	COG0686 Alanine dehydrogenase; Belongs to the AlaDH/PNT family. (376 aa)
	nanE	N-acetylmannosamine-6-phosphate 2-epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (239 aa)
	uxaC	COG1904 Glucuronate isomerase. (468 aa)
	uxuA	Mannonate dehydratase; Catalyzes the dehydration of D-mannonate. (364 aa)
	AET58889.1	Hypothetical protein; COG1228 Imidazolonepropionase and related amidohydrolases. (436 aa)
	AET59031.1	Fad dependent oxidoreductase; COG2081 Predicted flavoproteins. (426 aa)
	AET59231.1	Amidohydrolase; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; Belongs to the peptidase M20A family. (402 aa)
	AET60662.1	HpcH/HpaI aldolase; COG3836 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Belongs to the HpcH/HpaI aldolase family. (253 aa)
	AET59351.1	Amidohydrolase; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; Belongs to the peptidase M20A family. (406 aa)
	AET60819.1	COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; Belongs to the peptidase M20A family. (392 aa)
	AET60960.1	COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold; Belongs to the UPF0173 family. (229 aa)
	AET61080.1	COG3836 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Belongs to the HpcH/HpaI aldolase family. (248 aa)
	AET61098.1	COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase. (236 aa)
	AET61114.1	6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (467 aa)
	AET61145.1	Fumarylacetoacetate hydrolase; COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway). (292 aa)
	AET61652.1	6-phosphogluconate dehydrogenase, decarboxylating II (GNTZII); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa)
	dtd	d-tyrosyl-tRNA(tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (148 aa)
	gcvPB	Glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (489 aa)
	gcvPA	Glycine dehydrogenase [decarboxylating] subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (451 aa)
	gcvT	Glycine cleavage system aminomethyltransferase t; The glycine cleavage system catalyzes the degradation of glycine. (366 aa)
	gcvH	Glycine cleavage system H protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. (131 aa)
	AET62121.1	COG1878 Predicted metal-dependent hydrolase. (245 aa)
	arcA	COG2235 Arginine deiminase. (410 aa)
	AET61980.1	Aminobenzoyl-glutamate utilization protein B; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. (478 aa)
	AET61690.1	Mandelate racemase/muconate lactonizing protein; COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily. (399 aa)
	AET61609.1	Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (437 aa)
	nagB	Glucosamine-6-phosphate deaminase (glucosamine-6-phosphate isomerase); Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (242 aa)
	AET57260.1	COG1024 Enoyl-CoA hydratase/carnithine racemase. (278 aa)
	AET57261.1	COG1024 Enoyl-CoA hydratase/carnithine racemase. (279 aa)
	AET57336.1	COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold. (334 aa)
	AET58083.1	Acyl-CoA dehydrogenase type 2 domain-containing protein; COG1960 Acyl-CoA dehydrogenases. (394 aa)
	AET58320.1	COG0157 Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (296 aa)
	pdxT	Hypothetical protein; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (188 aa)
	AET58365.1	COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases. (286 aa)
	AET60566.1	COG2721 Altronate dehydratase. (499 aa)
	uxaC-2	COG1904 Glucuronate isomerase. (474 aa)

Your Current Organism:

Paenibacillus terrae

NCBI taxonomy Id: 985665
Other names: P. terrae HPL-003, Paenibacillus sp. HPL-003, Paenibacillus terrae HPL-003, Paenibacillus terrae str. HPL-003, Paenibacillus terrae strain HPL-003

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AET57260.1	AET57261.1	HPL003_02395	HPL003_02400	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG1024 Enoyl-CoA hydratase/carnithine racemase.	0.861
AET57260.1	AET58083.1	HPL003_02395	HPL003_06600	COG1024 Enoyl-CoA hydratase/carnithine racemase.	Acyl-CoA dehydrogenase type 2 domain-containing protein; COG1960 Acyl-CoA dehydrogenases.	0.947
AET57260.1	AET59572.1	HPL003_02395	HPL003_14105	COG1024 Enoyl-CoA hydratase/carnithine racemase.	3-ketoacid-coenzyme a transferase1; COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit.	0.514
AET57260.1	AET59573.1	HPL003_02395	HPL003_14110	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit.	0.501
AET57260.1	AET59575.1	HPL003_02395	HPL003_14120	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.988
AET57261.1	AET57260.1	HPL003_02400	HPL003_02395	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG1024 Enoyl-CoA hydratase/carnithine racemase.	0.861
AET57261.1	AET58083.1	HPL003_02400	HPL003_06600	COG1024 Enoyl-CoA hydratase/carnithine racemase.	Acyl-CoA dehydrogenase type 2 domain-containing protein; COG1960 Acyl-CoA dehydrogenases.	0.953
AET57261.1	AET59572.1	HPL003_02400	HPL003_14105	COG1024 Enoyl-CoA hydratase/carnithine racemase.	3-ketoacid-coenzyme a transferase1; COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit.	0.541
AET57261.1	AET59573.1	HPL003_02400	HPL003_14110	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit.	0.531
AET57261.1	AET59575.1	HPL003_02400	HPL003_14120	COG1024 Enoyl-CoA hydratase/carnithine racemase.	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.990
AET58083.1	AET57260.1	HPL003_06600	HPL003_02395	Acyl-CoA dehydrogenase type 2 domain-containing protein; COG1960 Acyl-CoA dehydrogenases.	COG1024 Enoyl-CoA hydratase/carnithine racemase.	0.947
AET58083.1	AET57261.1	HPL003_06600	HPL003_02400	Acyl-CoA dehydrogenase type 2 domain-containing protein; COG1960 Acyl-CoA dehydrogenases.	COG1024 Enoyl-CoA hydratase/carnithine racemase.	0.953
AET58083.1	AET59572.1	HPL003_06600	HPL003_14105	Acyl-CoA dehydrogenase type 2 domain-containing protein; COG1960 Acyl-CoA dehydrogenases.	3-ketoacid-coenzyme a transferase1; COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit.	0.484
AET58083.1	AET59573.1	HPL003_06600	HPL003_14110	Acyl-CoA dehydrogenase type 2 domain-containing protein; COG1960 Acyl-CoA dehydrogenases.	COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit.	0.484
AET58083.1	AET59575.1	HPL003_06600	HPL003_14120	Acyl-CoA dehydrogenase type 2 domain-containing protein; COG1960 Acyl-CoA dehydrogenases.	COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.976
AET58083.1	gcvT	HPL003_06600	HPL003_27550	Acyl-CoA dehydrogenase type 2 domain-containing protein; COG1960 Acyl-CoA dehydrogenases.	Glycine cleavage system aminomethyltransferase t; The glycine cleavage system catalyzes the degradation of glycine.	0.466
AET59572.1	AET57260.1	HPL003_14105	HPL003_02395	3-ketoacid-coenzyme a transferase1; COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit.	COG1024 Enoyl-CoA hydratase/carnithine racemase.	0.514
AET59572.1	AET57261.1	HPL003_14105	HPL003_02400	3-ketoacid-coenzyme a transferase1; COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit.	COG1024 Enoyl-CoA hydratase/carnithine racemase.	0.541
AET59572.1	AET58083.1	HPL003_14105	HPL003_06600	3-ketoacid-coenzyme a transferase1; COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit.	Acyl-CoA dehydrogenase type 2 domain-containing protein; COG1960 Acyl-CoA dehydrogenases.	0.484
AET59572.1	AET59573.1	HPL003_14105	HPL003_14110	3-ketoacid-coenzyme a transferase1; COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit.	COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit.	0.999

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