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| | hisI | Histidine biosynthesis bifunctional protein hisIE; COG0139 Phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. (246 aa) |
| | AET61991.1 | Aminoglycoside phosphotransferase; COG2334 Putative homoserine kinase type II (protein kinase fold). (335 aa) |
| | dapH | Tetrahydrodipicolinate N-succinyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (237 aa) |
| | AET61932.1 | Hypothetical protein; Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate. (378 aa) |
| | aroE-2 | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (289 aa) |
| | proC-2 | Late competence protein ComER; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (281 aa) |
| | AET61843.1 | Hypothetical protein; COG1246 N-acetylglutamate synthase and related acetyltransferases; Belongs to the acetyltransferase family. (158 aa) |
| | AET61771.1 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (320 aa) |
| | carA | COG0505 Carbamoylphosphate synthase small subunit; Belongs to the CarA family. (378 aa) |
| | carB | COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. (1072 aa) |
| | AET61703.1 | COG0332 3-oxoacyl-[acyl-carrier-protein] synthase III. (328 aa) |
| | AET61665.1 | COG0547 Anthranilate phosphoribosyltransferase. (357 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (430 aa) |
| | AET61642.1 | MTA/SAH nucleosidase (5'-methylthioadenosine nucleosidase); Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (232 aa) |
| | AET61627.1 | Hypothetical protein; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. (401 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (277 aa) |
| | AET61547.1 | COG0527 Aspartokinases; Belongs to the aspartokinase family. (417 aa) |
| | AET61538.1 | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (163 aa) |
| | AET61537.1 | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa) |
| | folD-2 | Methylenetetrahydrofolate dehydrogenase (nadp(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa) |
| | argR | Arginine repressor; Regulates arginine biosynthesis genes. (149 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (455 aa) |
| | AET61441.1 | N-acyl-L-amino acid amidohydrolase; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. (397 aa) |
| | AET61433.1 | COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (530 aa) |
| | AET61416.1 | Ferredoxin, 2Fe-2S; COG3894 Uncharacterized metal-binding protein. (116 aa) |
| | AET61413.1 | Alcohol dehydrogenase zinc-binding domain-containing protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. (310 aa) |
| | aroC | Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (389 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (364 aa) |
| | AET61395.1 | Chorismate mutase (CM); Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (124 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (516 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (348 aa) |
| | trpC | COG0134 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (264 aa) |
| | trpF | COG0135 Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (228 aa) |
| | trpB | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (398 aa) |
| | trpA | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa) |
| | hisC | Histidinol-phosphate aminotransferase (imidazole acetol-phosphate transaminase); COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (367 aa) |
| | AET61387.1 | COG0287 Prephenate dehydrogenase. (362 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (267 aa) |
| | AET61373.1 | COG2120 Uncharacterized proteins, LmbE homologs. (230 aa) |
| | panB-2 | 3-methyl-2-oxobutanoate hydroxymethyltransferase (Ketopantoate hydroxymethyltransferase); Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (304 aa) |
| | panC | Pantoate--beta-alanine ligase (Pantothenate synthetase); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (312 aa) |
| | panD | Aspartate 1-decarboxylase alpha chain; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (127 aa) |
| | mtnB | Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase); Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. (216 aa) |
| | mtnX | 2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphate phosphatase; Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). (225 aa) |
| | mtnW | 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; COG1850 Ribulose 1,5-bisphosphate carboxylase, large subunit; Belongs to the RuBisCO large chain family. (403 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (288 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (430 aa) |
| | AET61337.1 | COG0502 Biotin synthase and related enzymes. (336 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa) |
| | leuD-2 | 3-isopropylmalate dehydratase small subunit (Isopropylmalate isomerase); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa) |
| | nadA | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (368 aa) |
| | AET61202.1 | Diaminobutyrate--2-oxoglutarate aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (420 aa) |
| | AET61189.1 | Pks acyltransferase domain protein; COG0331 (acyl-carrier-protein) S-malonyltransferase. (407 aa) |
| | AET61117.1 | COG2364 Predicted membrane protein. (214 aa) |
| | AET61081.1 | Peptidase M20; COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (379 aa) |
| | AET60947.1 | COG0777 Acetyl-CoA carboxylase beta subunit. (557 aa) |
| | AET60946.1 | Malonate decarboxylase, delta subunit; COG3052 Citrate lyase, gamma subunit. (99 aa) |
| | AET60943.1 | Malonate decarboxylase, epsilon subunit; COG0331 (acyl-carrier-protein) S-malonyltransferase. (287 aa) |
| | leuA-2 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (514 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (335 aa) |
| | AET60869.1 | COG0656 Aldo/keto reductases, related to diketogulonate reductase. (63 aa) |
| | AET60837.1 | Crowt peptidase m20d; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. (390 aa) |
| | AET60799.1 | COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. (495 aa) |
| | AET60798.1 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (162 aa) |
| | AET60762.1 | Methionine synthase I, cobalamin-binding domain protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1146 aa) |
| | mtnD | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (180 aa) |
| | AET60749.1 | COG0174 Glutamine synthetase. (442 aa) |
| | AET60723.1 | Hypothetical protein; COG2100 Predicted Fe-S oxidoreductase. (292 aa) |
| | AET60663.1 | COG0019 Diaminopimelate decarboxylase. (410 aa) |
| | AET60658.1 | COG0160 4-aminobutyrate aminotransferase and related aminotransferases. (103 aa) |
| | AET60617.1 | O-acetylserine lyase; COG0031 Cysteine synthase. (307 aa) |
| | AET60594.1 | Hypothetical protein; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. (382 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | AET60431.1 | Aspartate kinase, monofunctional class; COG0527 Aspartokinases; Belongs to the aspartokinase family. (405 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase); Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (345 aa) |
| | AET60337.1 | 3-oxoacyl-(acyl carrier protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (412 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (77 aa) |
| | AET60334.1 | COG0331 (acyl-carrier-protein) S-malonyltransferase. (313 aa) |
| | fabH-3 | 3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (329 aa) |
| | plsX | Glycerol-3-phosphate acyltransferase plsx; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (330 aa) |
| | AET60259.1 | Hypothetical protein; COG0454 Histone acetyltransferase HPA2 and related acetyltransferases. (140 aa) |
| | AET60190.1 | 3-oxoacyl-(acyl carrier protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (412 aa) |
| | AET60155.1 | Putative alpha-isopropylmalate/homocitrate synthase family transferase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. (538 aa) |
| | fabV | trans-2-enoyl-CoA reductase; Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA); Belongs to the TER reductase family. (392 aa) |
| | AET60062.1 | Hypothetical protein; COG0620 Methionine synthase II (cobalamin-independent). (379 aa) |
| | accA | Acetyl-coenzyme a carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (327 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (ACCase subunit beta); Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (297 aa) |
| | AET59955.1 | COG0535 Predicted Fe-S oxidoreductases. (376 aa) |
| | mtnK | Methylthioribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (407 aa) |
| | mtnA | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (368 aa) |
| | AET59913.1 | COG4126 Hydantoin racemase. (211 aa) |
| | AET59911.1 | Hypothetical protein. (223 aa) |
| | serC | 3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (363 aa) |
| | AET59895.1 | COG0174 Glutamine synthetase. (474 aa) |
| | metAA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (305 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (358 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (513 aa) |
| | ilvC | Ketol-acid reductoisomerase 2; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa) |
| | AET59846.1 | COG0440 Acetolactate synthase, small (regulatory) subunit. (161 aa) |
| | AET59780.1 | COG0454 Histone acetyltransferase HPA2 and related acetyltransferases. (142 aa) |
| | AET59714.1 | Threonine-phosphate decarboxylase (L-threonine-O-3-phosphate decarboxylase); COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. (367 aa) |
| | AET59708.1 | COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I. (256 aa) |
| | AET59643.1 | Alanine racemase 1; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (398 aa) |
| | AET59608.1 | COG1893 Ketopantoate reductase. (195 aa) |
| | AET59607.1 | Hypothetical protein; COG5023 Tubulin. (109 aa) |
| | AET59606.1 | Putative oxidoreductase; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. (333 aa) |
| | AET59563.1 | COG0367 Asparagine synthase (glutamine-hydrolyzing). (641 aa) |
| | AET59552.1 | COG1004 Predicted UDP-glucose 6-dehydrogenase. (446 aa) |
| | AET59536.1 | COG1004 Predicted UDP-glucose 6-dehydrogenase. (442 aa) |
| | AET59519.1 | COG0067 Glutamate synthase domain 1. (1532 aa) |
| | AET59399.1 | Hypothetical protein; COG0656 Aldo/keto reductases, related to diketogulonate reductase. (80 aa) |
| | AET59376.1 | COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. (378 aa) |
| | AET59368.1 | Nitrogenase cofactor biosynthesis protein NifB; COG0535 Predicted Fe-S oxidoreductases. (499 aa) |
| | AET59342.1 | COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Belongs to the DapA family. (295 aa) |
| | AET59285.1 | Hypothetical protein; COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ). (343 aa) |
| | AET59242.1 | COG0031 Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (307 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (190 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (254 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (296 aa) |
| | AET59220.1 | COG3239 Fatty acid desaturase. (351 aa) |
| | folD | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa) |
| | ilvA | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (429 aa) |
| | AET59129.1 | Oxidoreductase, aldo/keto reductase family protein; COG0656 Aldo/keto reductases, related to diketogulonate reductase. (274 aa) |
| | fabH-2 | 3-oxoacyl-(acyl carrier protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (329 aa) |
| | AET59099.1 | Quinone oxidoreductase-like protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. (179 aa) |
| | AET59098.1 | Quinone oxidoreductase-like protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. (92 aa) |
| | AET59059.1 | Hypothetical protein; COG0535 Predicted Fe-S oxidoreductases. (347 aa) |
| | AET59049.1 | COG0095 Lipoate-protein ligase A. (276 aa) |
| | acpS | 4-phosphopantetheinyl transferase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (134 aa) |
| | AET59007.1 | COG0065 3-isopropylmalate dehydratase large subunit. (417 aa) |
| | AET59005.1 | COG0065 3-isopropylmalate dehydratase large subunit. (381 aa) |
| | AET59004.1 | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (366 aa) |
| | AET58975.1 | COG0656 Aldo/keto reductases, related to diketogulonate reductase. (283 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (290 aa) |
| | AET58952.1 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (307 aa) |
| | AET58907.1 | Oxidoreductase, zinc-binding protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. (332 aa) |
| | AET58899.1 | COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. (98 aa) |
| | AET58895.1 | Hypothetical protein. (213 aa) |
| | dapA | Hypothetical protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa) |
| | fabH | 3-oxoacyl-(acyl carrier protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (316 aa) |
| | AET58724.1 | COG3386 Gluconolactonase. (385 aa) |
| | AET58723.1 | COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. (336 aa) |
| | AET58598.1 | Hypothetical protein; COG0796 Glutamate racemase. (225 aa) |
| | AET58571.1 | Reductase; COG0656 Aldo/keto reductases, related to diketogulonate reductase. (280 aa) |
| | AET58427.1 | Histidinol-phosphatase; COG1387 Histidinol phosphatase and related hydrolases of the PHP family; Belongs to the PHP hydrolase family. HisK subfamily. (274 aa) |
| | AET62009.1 | COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (423 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF (IGP synthase cyclase subunit); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. (243 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (209 aa) |
| | hisB | COG0131 Imidazoleglycerol-phosphate dehydratase. (202 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa) |
| | hisG | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (214 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (401 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (427 aa) |
| | AET58330.1 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. (182 aa) |
| | AET58329.1 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (120 aa) |
| | AET58328.1 | Dihydropteroate synthase (dihydropteroate pyrophosphorylase); Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (288 aa) |
| | AET58327.1 | Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase); COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. (298 aa) |
| | AET58325.1 | COG0147 Anthranilate/para-aminobenzoate synthases component I. (538 aa) |
| | AET58324.1 | COG0031 Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (312 aa) |
| | AET58186.1 | Dihydrodipicolinate reductase. (72 aa) |
| | AET58164.1 | Dihydrofolate reductase-like protein; COG0262 Dihydrofolate reductase. (169 aa) |
| | AET58132.1 | Glycosyl transferase family 2; COG0535 Predicted Fe-S oxidoreductases. (319 aa) |
| | mmuM | COG2040 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent). (326 aa) |
| | AET58009.1 | COG0172 Seryl-tRNA synthetase. (429 aa) |
| | AET57902.1 | Protein yhdH; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. (335 aa) |
| | AET57854.1 | Amidohydrolase; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. (409 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (772 aa) |
| | hemD | COG1587 Uroporphyrinogen-III synthase. (281 aa) |
| | glyA | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase fabz; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (148 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase (AGPR); Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (349 aa) |
| | argJ | Arginine biosynthesis bifunctional protein argJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (408 aa) |
| | argB | Acetylglutamate kinase (NAG kinase); Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (279 aa) |
| | argD | COG4992 Ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (422 aa) |
| | argF | Ornithine carbamoyltransferase (argf); Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (318 aa) |
| | argG | COG0137 Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (411 aa) |
| | argH | COG0165 Argininosuccinate lyase. (470 aa) |
| | AET57618.1 | COG0155 Sulfite reductase, beta subunit (hemoprotein); Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (541 aa) |
| | AET57575.1 | COG1045 Serine acetyltransferase. (226 aa) |
| | cysH | Phosphoadenosine phosphosulfate reductase (PAPS reductase, thioredoxin dependent); Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (230 aa) |
| | AET57477.1 | Amidohydrolase; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. (394 aa) |
| | AET57262.1 | Amidohydrolase; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. (405 aa) |
| | AET57184.1 | Alcohol dehydrogenase zinc-binding domain-containing protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. (313 aa) |
| | AET57175.1 | COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. (333 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (300 aa) |
| | AET57017.1 | PHP family hydrolase; COG1387 Histidinol phosphatase and related hydrolases of the PHP family; Belongs to the PHP hydrolase family. HisK subfamily. (269 aa) |
| | AET56952.1 | COG0236 Acyl carrier protein. (92 aa) |
| | AET56950.1 | COG0439 Biotin carboxylase. (458 aa) |
| | AET56944.1 | Hypothetical protein. (511 aa) |
| | AET56941.1 | COG0019 Diaminopimelate decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (428 aa) |
| | AET56923.1 | Hypothetical protein; COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (451 aa) |
| | AET56900.1 | COG0367 Asparagine synthase (glutamine-hydrolyzing). (614 aa) |
| | AET56876.1 | COG1893 Ketopantoate reductase. (297 aa) |
| | AET56875.1 | Putative oxidoreductase; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. (329 aa) |
| | AET56870.1 | Oxidoreductase; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. (316 aa) |
| | AET56791.1 | COG0460 Homoserine dehydrogenase. (428 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (322 aa) |
| | pheA | COG0077 Prephenate dehydratase. (298 aa) |
| | ilvE | Branched-chain-amino acid aminotransferase (transaminase B); Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (294 aa) |
| | citD | Citrate lyase subunit gamma; Covalent carrier of the coenzyme of citrate lyase. (97 aa) |
| | ilvD | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (556 aa) |
| | fabV-2 | trans-2-enoyl-CoA reductase; Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA); Belongs to the TER reductase family. (395 aa) |
| | argR-2 | Arginine repressor; Regulates arginine biosynthesis genes. (150 aa) |
| | argF-2 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (332 aa) |
| | AET62076.1 | COG0693 Putative intracellular protease/amidase. (208 aa) |
