STRINGSTRING
ilvE ilvE AET56791.1 AET56791.1 AET57259.1 AET57259.1 AET57269.1 AET57269.1 AET57575.1 AET57575.1 metK metK metE metE AET57970.1 AET57970.1 mmuM mmuM AET58324.1 AET58324.1 speE speE AET58682.1 AET58682.1 AET58683.1 AET58683.1 ldh ldh AET58797.1 AET58797.1 luxS luxS AET59019.1 AET59019.1 AET59163.1 AET59163.1 AET59242.1 AET59242.1 speD speD metAA metAA AET59880.1 AET59880.1 AET59881.1 AET59881.1 serC serC mtnA mtnA mtnK mtnK mdh mdh AET60062.1 AET60062.1 asd asd AET60431.1 AET60431.1 AET60617.1 AET60617.1 AET60618.1 AET60618.1 mtnD mtnD AET60762.1 AET60762.1 ldh-2 ldh-2 AET60925.1 AET60925.1 AET61086.1 AET61086.1 AET61263.1 AET61263.1 AET61342.1 AET61342.1 mtnW mtnW mtnX mtnX mtnB mtnB mtaD mtaD AET61433.1 AET61433.1 AET61547.1 AET61547.1 mtaD-2 mtaD-2 AET61614.1 AET61614.1 AET61642.1 AET61642.1 ahcY ahcY AET61936.1 AET61936.1 AET62070.1 AET62070.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ilvEBranched-chain-amino acid aminotransferase (transaminase B); Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (294 aa)
AET56791.1COG0460 Homoserine dehydrogenase. (428 aa)
AET57259.1COG1760 L-serine deaminase. (402 aa)
AET57269.1D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding subunit; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (315 aa)
AET57575.1COG1045 Serine acetyltransferase. (226 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (400 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (772 aa)
AET57970.1Hypothetical protein; COG0402 Cytosine deaminase and related metal-dependent hydrolases. (453 aa)
mmuMCOG2040 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent). (326 aa)
AET58324.1COG0031 Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (312 aa)
speESpermidine synthase (Putrescine aminopropyltransferase) (SPDSY); Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (275 aa)
AET58682.1L-serine dehydratase subunit alpha; COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (299 aa)
AET58683.1L-serine dehydratase subunit beta; COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (229 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. (318 aa)
AET58797.1COG2873 O-acetylhomoserine sulfhydrylase. (430 aa)
luxSS-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (153 aa)
AET59019.1UPF0067 protein yebR; COG1956 GAF domain-containing protein. (159 aa)
AET59163.1DNA-cytosine methyltransferase; COG0270 Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (569 aa)
AET59242.1COG0031 Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (307 aa)
speDS-adenosylmethionine decarboxylase; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. (268 aa)
metAAHomoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (305 aa)
AET59880.1COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (394 aa)
AET59881.1COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (392 aa)
serC3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (363 aa)
mtnAMethylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (368 aa)
mtnKMethylthioribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (407 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (313 aa)
AET60062.1Hypothetical protein; COG0620 Methionine synthase II (cobalamin-independent). (379 aa)
asdAspartate-semialdehyde dehydrogenase (ASA dehydrogenase); Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (345 aa)
AET60431.1Aspartate kinase, monofunctional class; COG0527 Aspartokinases; Belongs to the aspartokinase family. (405 aa)
AET60617.1O-acetylserine lyase; COG0031 Cysteine synthase. (307 aa)
AET60618.1COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (378 aa)
mtnD1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (180 aa)
AET60762.1Methionine synthase I, cobalamin-binding domain protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1146 aa)
ldh-2L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (309 aa)
AET60925.1Aminotransferase class I and II; COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities. (405 aa)
AET61086.1Aminotransferase class I and II; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (405 aa)
AET61263.1COG0421 Spermidine synthase. (248 aa)
AET61342.1Transaminase mtnE; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (393 aa)
mtnW2,3-diketo-5-methylthiopentyl-1-phosphate enolase; COG1850 Ribulose 1,5-bisphosphate carboxylase, large subunit; Belongs to the RuBisCO large chain family. (403 aa)
mtnX2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphate phosphatase; Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). (225 aa)
mtnBMethylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase); Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. (216 aa)
mtaDCytosine deaminase and like metal-dependent hydrolase; Catalyzes the deamination of 5-methylthioadenosine and S- adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine. Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family. (433 aa)
AET61433.1COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (530 aa)
AET61547.1COG0527 Aspartokinases; Belongs to the aspartokinase family. (417 aa)
mtaD-2Chlorohydrolase; Catalyzes the deamination of 5-methylthioadenosine and S- adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine. Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family. (429 aa)
AET61614.1Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain. (630 aa)
AET61642.1MTA/SAH nucleosidase (5'-methylthioadenosine nucleosidase); Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (232 aa)
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (421 aa)
AET61936.13-mercaptopyruvate sulfurtransferase (Rhodanese-like protein); COG2897 Rhodanese-related sulfurtransferase. (282 aa)
AET62070.1DNA-cytosine methyltransferase; COG0270 Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (375 aa)
Your Current Organism:
Paenibacillus terrae
NCBI taxonomy Id: 985665
Other names: P. terrae HPL-003, Paenibacillus sp. HPL-003, Paenibacillus terrae HPL-003, Paenibacillus terrae str. HPL-003, Paenibacillus terrae strain HPL-003
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