(71 nodes) Glyoxylate and dicarboxylate metabolism network (Leptosphaeria maculans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LEMA_P009910.1	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (738 aa)
	LEMA_P011710.1	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (592 aa)
	LEMA_P000080.1	Uncharacterized protein. (642 aa)
	LEMA_P002210.1	MFS domain-containing protein. (708 aa)
	LEMA_P007240.1	Uncharacterized protein. (809 aa)
	LEMA_P008330.1	Similar to formamidase. (399 aa)
	LEMA_P008370.1	PNPLA domain-containing protein. (678 aa)
	LEMA_P008490.1	Similar to D-isomer specific 2-hydroxyacid dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (335 aa)
	LEMA_P049320.1	AMP-binding domain-containing protein. (126 aa)
	LEMA_P049330.1	Uncharacterized protein. (244 aa)
	LEMA_P048030.1	Similar to D-glycerate 3-kinase. (296 aa)
	LEMA_P048300.1	Aminotran_5 domain-containing protein. (653 aa)
	LEMA_P064900.1	Similar to dihydrodipicolinate synthetase family protein; Belongs to the DapA family. (327 aa)
	LEMA_P066210.1	MFS domain-containing protein. (543 aa)
	LEMA_P057140.1	Similar to ATPase family AAA domain-containing protein 1; Belongs to the AAA ATPase family. (453 aa)
	LEMA_P060650.1	Uncharacterized protein. (399 aa)
	LEMA_P067520.1	Similar to D-mandelate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (376 aa)
	LEMA_P069320.1	Uncharacterized protein. (715 aa)
	LEMA_P054370.1	Uncharacterized protein. (296 aa)
	LEMA_P056070.1	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (464 aa)
	LEMA_P038540.1	Similar to glutamine synthetase; Belongs to the glutamine synthetase family. (487 aa)
	LEMA_P039540.1	Isocitrate lyase. (600 aa)
	LEMA_P039550.1	Citrate synthase; Belongs to the citrate synthase family. (463 aa)
	LEMA_P042770.1	Acetyl-coenzyme A synthetase. (672 aa)
	LEMA_P039870.1	Malate synthase; Belongs to the malate synthase family. (543 aa)
	LEMA_P039980.1	PNPLA domain-containing protein. (362 aa)
	LEMA_P032960.1	MFS domain-containing protein. (492 aa)
	LEMA_P037640.1	Similar to glyoxylate/hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (386 aa)
	LEMA_P035380.1	Similar to PEP phosphonomutase. (261 aa)
	LEMA_P121590.1	PNPLA domain-containing protein. (505 aa)
	LEMA_P121650.1	SET domain-containing protein. (632 aa)
	LEMA_P121780.1	Similar to acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (431 aa)
	LEMA_P119880.1	PAC domain-containing protein. (815 aa)
	LEMA_P117650.1	Uncharacterized protein. (1089 aa)
	LEMA_P113590.1	Similar to SET domain-containing protein. (415 aa)
	LEMA_P114360.1	Uncharacterized protein. (419 aa)
	LEMA_P026160.1	2-Hacid_dh_C domain-containing protein. (441 aa)
	LEMA_P026250.1	Similar to acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (341 aa)
	LEMA_P028960.1	MFS domain-containing protein. (607 aa)
	LEMA_P031340.1	PNPLA domain-containing protein. (537 aa)
	LEMA_P023590.1	PNPLA domain-containing protein. (377 aa)
	LEMA_P025090.1	Similar to dihydrodipicolinate synthetase family protein. (364 aa)
	LEMA_P111610.1	Similar to propionyl-CoA carboxylase. (585 aa)
	LEMA_P107540.1	Zn(2)-C6 fungal-type domain-containing protein. (1007 aa)
	LEMA_P107310.1	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (171 aa)
	LEMA_P100000.1	Uncharacterized protein. (456 aa)
	LEMA_P101050.1	Formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (363 aa)
	LEMA_P101170.1	Similar to oxalate decarboxylase oxdC. (388 aa)
	LEMA_P101280.1	Citrate synthase; Belongs to the citrate synthase family. (467 aa)
	LEMA_P093590.1	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (743 aa)
	LEMA_P095870.1	Similar to developmental protein fluG; Belongs to the glutamine synthetase family. (930 aa)
	LEMA_P093910.1	Similar to dihydrodipicolinate synthetase family protein; Belongs to the DapA family. (313 aa)
	LEMA_P097830.1	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (781 aa)
	LEMA_P098650.1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (471 aa)
	LEMA_P079810.1	Similar to SET domain containing protein. (479 aa)
	LEMA_P081280.1	Similar to peroxisomal (S)-2-hydroxy-acid oxidase. (400 aa)
	LEMA_P084160.1	Malate dehydrogenase. (339 aa)
	LEMA_P076050.1	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1077 aa)
	LEMA_P015350.1	Uncharacterized protein. (123 aa)
	LEMA_P015360.1	Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. (283 aa)
	LEMA_P016790.1	Uncharacterized protein. (269 aa)
	LEMA_P017540.1	Similar to formyltetrahydrofolate deformylase. (282 aa)
	LEMA_P018730.1	Malate dehydrogenase. (330 aa)
	LEMA_P020790.1	PNPLA domain-containing protein. (686 aa)
	LEMA_P009410.1	Uncharacterized protein. (1466 aa)
	LEMA_P009620.1	Dihydrolipoyl dehydrogenase. (1386 aa)
	LEMA_P010040.1	PNPLA domain-containing protein. (744 aa)
	LEMA_P010800.1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (520 aa)
	LEMA_P011370.1	Similar to alpha/beta hydrolase. (565 aa)
	LEMA_P011380.1	2OG-FeII_Oxy_2 domain-containing protein. (975 aa)
	LEMA_P011480.1	Similar to catalase. (647 aa)

Your Current Organism:

Leptosphaeria maculans

NCBI taxonomy Id: 985895
Other names: L. maculans JN3, Leptosphaeria maculans JN3, Leptosphaeria maculans v23.1.3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LEMA_P000080.1	LEMA_P008490.1	E5ADD2	E5AFS3	Uncharacterized protein.	Similar to D-isomer specific 2-hydroxyacid dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.793
LEMA_P000080.1	LEMA_P011380.1	E5ADD2	E5ACZ9	Uncharacterized protein.	2OG-FeII_Oxy_2 domain-containing protein.	0.644
LEMA_P000080.1	LEMA_P018730.1	E5ADD2	E5AAQ2	Uncharacterized protein.	Malate dehydrogenase.	0.652
LEMA_P000080.1	LEMA_P025090.1	E5ADD2	E4ZXE7	Uncharacterized protein.	Similar to dihydrodipicolinate synthetase family protein.	0.758
LEMA_P000080.1	LEMA_P026160.1	E5ADD2	E4ZV38	Uncharacterized protein.	2-Hacid_dh_C domain-containing protein.	0.563
LEMA_P000080.1	LEMA_P037640.1	E5ADD2	E4ZQT5	Uncharacterized protein.	Similar to glyoxylate/hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.792
LEMA_P000080.1	LEMA_P039540.1	E5ADD2	E4ZNJ4	Uncharacterized protein.	Isocitrate lyase.	0.763
LEMA_P000080.1	LEMA_P039550.1	E5ADD2	E4ZNJ5	Uncharacterized protein.	Citrate synthase; Belongs to the citrate synthase family.	0.839
LEMA_P000080.1	LEMA_P039870.1	E5ADD2	E4ZP61	Uncharacterized protein.	Malate synthase; Belongs to the malate synthase family.	0.995
LEMA_P000080.1	LEMA_P042770.1	E5ADD2	E4ZP07	Uncharacterized protein.	Acetyl-coenzyme A synthetase.	0.762
LEMA_P000080.1	LEMA_P048300.1	E5ADD2	E5R5F4	Uncharacterized protein.	Aminotran_5 domain-containing protein.	0.875
LEMA_P000080.1	LEMA_P064900.1	E5ADD2	E4ZGE4	Uncharacterized protein.	Similar to dihydrodipicolinate synthetase family protein; Belongs to the DapA family.	0.758
LEMA_P000080.1	LEMA_P067520.1	E5ADD2	E4ZIX4	Uncharacterized protein.	Similar to D-mandelate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.793
LEMA_P000080.1	LEMA_P081280.1	E5ADD2	E5A5J1	Uncharacterized protein.	Similar to peroxisomal (S)-2-hydroxy-acid oxidase.	0.800
LEMA_P000080.1	LEMA_P084160.1	E5ADD2	E5A6D2	Uncharacterized protein.	Malate dehydrogenase.	0.652
LEMA_P000080.1	LEMA_P093910.1	E5ADD2	E5A3V8	Uncharacterized protein.	Similar to dihydrodipicolinate synthetase family protein; Belongs to the DapA family.	0.758
LEMA_P000080.1	LEMA_P097830.1	E5ADD2	E5A429	Uncharacterized protein.	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	0.903
LEMA_P000080.1	LEMA_P101050.1	E5ADD2	E5A0B4	Uncharacterized protein.	Formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	0.583
LEMA_P000080.1	LEMA_P101280.1	E5ADD2	E5A0D7	Uncharacterized protein.	Citrate synthase; Belongs to the citrate synthase family.	0.839
LEMA_P000080.1	LEMA_P111610.1	E5ADD2	E4ZXZ7	Uncharacterized protein.	Similar to propionyl-CoA carboxylase.	0.407