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ADSL ADSL HAO2 HAO2 AMT AMT LIPT1 LIPT1 ALAS1 ALAS1 SRR SRR MTHFD2 MTHFD2 AGXT AGXT ALDH1L2 ALDH1L2 PHGDH PHGDH GCSH GCSH TYMS TYMS GAD1 GAD1 GLUD1 GLUD1 DHFR DHFR AGXT2 AGXT2 GLS GLS PIPOX PIPOX GAD2 GAD2 CARNMT1 CARNMT1 LIPT2 LIPT2 E1BDC8_BOVIN E1BDC8_BOVIN SDSL SDSL FPGS FPGS LOC507443 LOC507443 THNSL1 THNSL1 GART GART GLS2 GLS2 MTHFD1 MTHFD1 PGP PGP PAICS PAICS ALDH18A1 ALDH18A1 PSPH PSPH LIPM LIPM PSAT1 PSAT1 LIAS LIAS AK9 AK9 SHMT1 SHMT1 FADS6 FADS6 CARNS1 CARNS1 DAO DAO ATIC ATIC GRHPR GRHPR MTHFS MTHFS F1MBI9_BOVIN F1MBI9_BOVIN CNDP1 CNDP1 MTFMT MTFMT DPYS DPYS CNDP2 CNDP2 DMGDH DMGDH GLDC GLDC TDH TDH SHMT2 SHMT2 ALDH1L1 ALDH1L1 PFAS PFAS SDS SDS ADSS2 ADSS2 PPAT PPAT E1BEA7_BOVIN E1BEA7_BOVIN PYROXD1 PYROXD1 E1BBV5_BOVIN E1BBV5_BOVIN MTHFD1L MTHFD1L MTHFD2L MTHFD2L GLUL GLUL ENSBTAP00000059918 ENSBTAP00000059918 GNMT GNMT ENSBTAP00000062087 ENSBTAP00000062087 LOC529488 LOC529488 ENSBTAP00000064241 ENSBTAP00000064241 ENSBTAP00000064914 ENSBTAP00000064914 ALAS2 ALAS2 MTR MTR GLS-2 GLS-2 UPB1 UPB1 MTHFR MTHFR FTCD FTCD ENSBTAP00000072240 ENSBTAP00000072240 ENSBTAP00000074447 ENSBTAP00000074447 SARDH SARDH
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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ADSLAdenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (490 aa)
HAO2Hydroxyacid oxidase 2; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. (353 aa)
AMTAminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (397 aa)
LIPT1Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes; Belongs to the LplA family. (373 aa)
ALAS15-aminolevulinate synthase, nonspecific, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (752 aa)
SRRSerine racemase; Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine (By similarity). (334 aa)
MTHFD2Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. (378 aa)
AGXTSerine--pyruvate aminotransferase. (414 aa)
ALDH1L210-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (923 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
GCSHGlycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Belongs to the GcvH family. (173 aa)
TYMSThymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. (354 aa)
GAD1Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family. (594 aa)
GLUD1Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (561 aa)
DHFRDihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2 (By similarity). (187 aa)
AGXT2Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (514 aa)
GLSGlutaminase. (603 aa)
PIPOXPeroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline. Belongs to the MSOX/MTOX family. (392 aa)
GAD2Glutamate decarboxylase 2. (585 aa)
CARNMT1Carnosine N-methyltransferase 1. (484 aa)
LIPT2Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. Belongs to the LipB family. (225 aa)
E1BDC8_BOVINGlycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (177 aa)
SDSLSerine dehydratase like. (329 aa)
FPGSFolylpolyglutamate synthase, mitochondrial; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (585 aa)
LOC507443Beta_elim_lyase domain-containing protein. (392 aa)
THNSL1Threonine synthase like 1. (748 aa)
GARTTrifunctional purine biosynthetic protein adenosine-3; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. (1010 aa)
GLS2Glutaminase 2. (602 aa)
MTHFD1Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (935 aa)
PGPGlycerol-3-phosphate phosphatase; Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3- phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP. (321 aa)
PAICSUncharacterized protein. (834 aa)
ALDH18A1Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (795 aa)
PSPHPhosphoserine phosphatase; Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity); Belongs to the HAD-like hydrolase superfamily. SerB family. (225 aa)
LIPMLipase; Belongs to the AB hydrolase superfamily. Lipase family. (415 aa)
PSAT1Phosphoserine aminotransferase. (438 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (372 aa)
AK9Adenylate kinase 9. (679 aa)
SHMT1Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. (484 aa)
FADS6Fatty acid desaturase 6; Belongs to the fatty acid desaturase type 1 family. (342 aa)
CARNS1Carnosine synthase 1. (951 aa)
DAOD-amino acid oxidase. (347 aa)
ATICPhosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. (592 aa)
GRHPRGlyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa)
MTHFS5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (201 aa)
F1MBI9_BOVINGlycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (166 aa)
CNDP1Carnosine dipeptidase 1. (510 aa)
MTFMTMethionyl-tRNA formyltransferase, mitochondrial; Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism; Belongs to the Fmt family. (390 aa)
DPYSDihydropyrimidinase. (516 aa)
CNDP2Cytosolic non-specific dipeptidase; Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Catalyzes the production of N- lactoyl-amino acids from lactate and amino acids by reverse proteolysis. (475 aa)
DMGDHDimethylglycine dehydrogenase. (870 aa)
GLDCGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1020 aa)
TDHL-threonine 3-dehydrogenase, mitochondrial; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate, mediating L-threonine catabolism. (373 aa)
SHMT2Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial tran [...] (504 aa)
ALDH1L110-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (902 aa)
PFASPhosphoribosylformylglycinamidine synthase. (1367 aa)
SDSL-serine dehydratase/L-threonine deaminase; Belongs to the serine/threonine dehydratase family. (446 aa)
ADSS2Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (456 aa)
PPATAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (539 aa)
E1BEA7_BOVINGlycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (173 aa)
PYROXD1Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; Probable FAD-dependent oxidoreductase; involved in the cellular oxidative stress response (By similarity). Required for normal sarcomere structure and muscle fiber integrity (By similarity). (518 aa)
E1BBV5_BOVINGlycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (166 aa)
MTHFD1LMonofunctional C1-tetrahydrofolate synthase, mitochondrial; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. (975 aa)
MTHFD2LUncharacterized protein. (347 aa)
GLULGlutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating [...] (373 aa)
ENSBTAP00000059918Uncharacterized protein. (143 aa)
GNMTGlycine N-methyltransferase. (295 aa)
ENSBTAP00000062087Uncharacterized protein. (77 aa)
LOC529488Uncharacterized protein. (628 aa)
ENSBTAP00000064241Amidase domain-containing protein. (364 aa)
ENSBTAP00000064914Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. (372 aa)
ALAS25-aminolevulinate synthase, erythroid-specific, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (613 aa)
MTRMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). (1265 aa)
GLS-2ANK_REP_REGION domain-containing protein. (93 aa)
UPB1Beta-ureidopropionase 1. (468 aa)
MTHFRMethylenetetrahydrofolate reductase; Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. (696 aa)
FTCDFormimidoyltransferase cyclodeaminase. (625 aa)
ENSBTAP00000072240Uncharacterized protein. (137 aa)
ENSBTAP00000074447Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (191 aa)
SARDHSarcosine dehydrogenase. (954 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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