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| | MGC127055 | Uncharacterized protein MGC127055; Belongs to the cytochrome P450 family. (500 aa) |
| | LOC527083 | Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa) |
| | AKR1D1 | Aldo-keto reductase family 1 member D1. (326 aa) |
| | HSD11B1L | Hydroxysteroid 11-beta-dehydrogenase 1-like protein. (287 aa) |
| | CYP51A1 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] (502 aa) |
| | HSD3B7 | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; Belongs to the 3-beta-HSD family. (368 aa) |
| | SLC35A2 | UDP-galactose translocator; Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function. (396 aa) |
| | FMO2 | Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa) |
| | MSMO1 | Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. (293 aa) |
| | SRD5A2 | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa) |
| | HSD17B2 | 17-beta hydroxysteroid dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (388 aa) |
| | LOC615303 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa) |
| | CYP39A1 | CYP39A1 protein; Belongs to the cytochrome P450 family. (469 aa) |
| | IDI1 | Isopentenyl-diphosphate Delta-isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). (287 aa) |
| | LOC112449566 | Uncharacterized protein; Belongs to the cytochrome P450 family. (457 aa) |
| | MVK | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (396 aa) |
| | CYP7A1 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (500 aa) |
| | LOC505468 | Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa) |
| | CYP3A4 | Uncharacterized protein. (503 aa) |
| | SQLE | Squalene monooxygenase. (572 aa) |
| | G3X6I9_BOVIN | Uncharacterized protein; Belongs to the cytochrome P450 family. (413 aa) |
| | HSD11B2 | Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Affinity towards corticosterone is higher than cortisol or dexamethasone; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (373 aa) |
| | HSD17B7 | Hydroxysteroid 17-beta dehydrogenase 7. (334 aa) |
| | LOC540627 | Uncharacterized protein; Belongs to the cytochrome P450 family. (491 aa) |
| | CYP11A1 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa) |
| | HSD3B1 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. (382 aa) |
| | ALDH1A3 | Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa) |
| | NR1I3 | Nuclear receptor subfamily 1 group I member 3. (406 aa) |
| | NSDHL | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis. (356 aa) |
| | DHRS11 | Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta- hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. (330 aa) |
| | AKR1C4 | Dihydrodiol dehydrogenase 3. (323 aa) |
| | FDPS | Farnesyl pyrophosphate synthase; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity). (421 aa) |
| | HSD17B6 | 17-beta-hydroxysteroid dehydrogenase type 6; NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17- beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to [...] (317 aa) |
| | SULT1E1 | Sulfotransferase 1E1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (By similarity). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine (By similarity). (295 aa) |
| | CYP4B1 | Cytochrome P450, family 4, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (511 aa) |
| | ERG28 | Chromosome 14 open reading frame 1 ortholog. (140 aa) |
| | MVD | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes; Belongs to the diphosphomevalonate decarboxylase family. (400 aa) |
| | CYP3A5 | Cytochrome P450 3A28; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (507 aa) |
| | CYP26B1 | Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13- cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required [...] (512 aa) |
| | FDFT1 | Squalene synthase; Critical branch point enzyme of isoprenoid biosynthesis that is thought to regulate the flux of isoprene intermediates through the sterol pathway; Belongs to the phytoene/squalene synthase family. (417 aa) |
| | GGPS1 | Geranylgeranyl pyrophosphate synthase; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins; Belongs to the FPP/GGPP synthase family. (300 aa) |
| | CYP27A1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (537 aa) |
| | LOC112441470 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (509 aa) |
| | CYP19A1 | Aromatase; A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19- aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19 [...] (503 aa) |
| | SRD5A3 | Steroid 5 alpha-reductase 3. (318 aa) |
| | HSD11B1 | Hydroxysteroid 11-beta dehydrogenase 1. (338 aa) |
| | SRD5A1 | 3-oxo-5-alpha-steroid 4-dehydrogenase 1; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity). (257 aa) |
| | CYP4X1 | Cytochrome P450 family 4 subfamily X member 1; Belongs to the cytochrome P450 family. (471 aa) |
| | DHCR7 | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC); Belongs to the ERG4/ERG24 family. (475 aa) |
| | HSD17B3 | Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (310 aa) |
| | UGT2B10 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa) |
| | PMVK | Phosphomevalonate kinase. (192 aa) |
| | LOC112449293 | Aldo_ket_red domain-containing protein. (190 aa) |
| | CYP2S1 | CYP2S1 protein; Belongs to the cytochrome P450 family. (494 aa) |
| | CYP2E1 | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. (509 aa) |
| | CBR3 | Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa) |
| | LSS | Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency. (732 aa) |
| | NR1I2 | Nuclear receptor subfamily 1 group I member 2. (420 aa) |
| | RGS22 | Regulator of G protein signaling 22. (1145 aa) |
| | CYP2C87 | Uncharacterized protein; Belongs to the cytochrome P450 family. (492 aa) |
| | AKR1C3 | Aldo_ket_red domain-containing protein. (323 aa) |
| | LOC100138004 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (531 aa) |
| | LOC781988 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa) |
| | LOC527068 | Aldo_ket_red domain-containing protein. (323 aa) |
| | CYP2C19 | CYP2C19 protein; Belongs to the cytochrome P450 family. (490 aa) |
| | CES2 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (553 aa) |
| | LOC508916 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (566 aa) |
| | LOC511498 | Uncharacterized protein; Belongs to the cytochrome P450 family. (495 aa) |
| | UGT1A1 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa) |
| | CYP2D14 | Cytochrome P450 2D14; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (500 aa) |
| | LOC538060-2 | Aldo_ket_red domain-containing protein. (323 aa) |
| | LOC782884 | Aldo_ket_red domain-containing protein. (324 aa) |
| | LOC506594 | Aldo_ket_red domain-containing protein. (312 aa) |
| | CYP2C18 | Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa) |
| | MGC127133 | 20-beta-hydroxysteroid dehydrogenase-like; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (286 aa) |
| | CYP8B1 | Cytochrome P450, family 8, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (166 aa) |
| | SDR42E1 | Short-chain dehydrogenase/reductase family 42E member 1. (393 aa) |
| | CYP11B1 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] (503 aa) |
| | F1MG97_BOVIN | Uncharacterized protein; Belongs to the cytochrome P450 family. (459 aa) |
| | CYP4A11 | Uncharacterized protein; Belongs to the cytochrome P450 family. (514 aa) |
| | CYP26C1 | Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (523 aa) |
| | MGC152010 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa) |
| | UGT2A1 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa) |
| | 20ALPHA-HSD | Aldo_ket_red domain-containing protein. (323 aa) |
| | CYP1A1 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (516 aa) |
| | HSD17B1 | Hydroxysteroid (17-beta) dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa) |
| | MROH5 | Uncharacterized protein. (395 aa) |
| | CYP21 | Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. (496 aa) |
| | LOC540707 | Cytochrome P450 2A; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (450 aa) |
| | CYP2F1 | Cytochrome P450 family 2 subfamily F member 1; Belongs to the cytochrome P450 family. (473 aa) |
| | LOC522146 | Uncharacterized protein; Belongs to the cytochrome P450 family. (491 aa) |
| | CYP3A5-2 | Cytochrome P450, family 3, subfamily A, polypeptide 5. (503 aa) |
| | DCXR-2 | L-xylulose reductase. (244 aa) |
| | SULT2B1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (338 aa) |
| | ENSBTAP00000057410 | Tnp_22_trimer domain-containing protein. (237 aa) |
| | LOC782787 | Uncharacterized protein. (310 aa) |
| | CYP2B6 | Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa) |
| | CYB5RL | NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (314 aa) |
| | ENSBTAP00000060742 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (486 aa) |
| | CYB5R3 | NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (358 aa) |
| | LOC100296421 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa) |
| | TM7SF2 | Delta(14)-sterol reductase TM7SF2; Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. (453 aa) |
| | CYP2J2-2 | Uncharacterized protein; Belongs to the cytochrome P450 family. (502 aa) |
| | STS | Steroid sulfatase. (596 aa) |
| | LOC100138908 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (532 aa) |
| | CYP3A24 | Uncharacterized protein. (503 aa) |
| | ENSBTAP00000064434 | Uncharacterized protein. (370 aa) |
| | LOC521656 | Uncharacterized protein; Belongs to the cytochrome P450 family. (502 aa) |
| | CYP46A1 | Cytochrome P450, family 46, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (501 aa) |
| | SIGMAR1 | Sigma non-opioid intracellular receptor 1; Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. [...] (267 aa) |
| | POR | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the N-terminal section; belongs to the flavodoxin family. (804 aa) |
| | CYB5A | Cytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. (134 aa) |
| | CYP7B1 | Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (446 aa) |
| | ENSBTAP00000068322 | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa) |
| | LOC530571 | Uncharacterized protein; Belongs to the cytochrome P450 family. (498 aa) |
| | LOC112444495 | Steroid 17-alpha-hydroxylase/17,20 lyase. (509 aa) |
| | LOC530553 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa) |
| | DHCR24 | 24-dehydrocholesterol reductase. (550 aa) |
| | CYB5B | Cytochrome b5 type B; Belongs to the cytochrome b5 family. (146 aa) |
| | LOC540544 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa) |
| | LOC100140261 | Uncharacterized protein. (370 aa) |
| | ENSBTAP00000071522 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (494 aa) |
| | CBR1 | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity) [...] (281 aa) |
| | SC5D | Sterol-C5-desaturase; Belongs to the sterol desaturase family. (336 aa) |
| | ENSBTAP00000072976 | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. (334 aa) |
| | CES1 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa) |
