STRINGSTRING
THEM5 THEM5 ATAD1 ATAD1 ETFBKMT ETFBKMT PEX3 PEX3 ACOT2 ACOT2 SNX15 SNX15 ACOT4 ACOT4 SCP2 SCP2 PEX2 PEX2 AP1AR AP1AR PEX13 PEX13 PEX6 PEX6 EFCC1 EFCC1 PEX11A PEX11A PXMP2 PXMP2 PEX19 PEX19 PEX11B PEX11B FAR1 FAR1 TMEM100 TMEM100 DNAL1 DNAL1 LOC512541 LOC512541 LRRN4CL LRRN4CL LONP2 LONP2 FAR2 FAR2 ACOT9 ACOT9 GDAP1 GDAP1 PEX5L PEX5L DBIL5 DBIL5 TMEM63C TMEM63C PEX7 PEX7 ACBD5 ACBD5 PEX11G PEX11G CTDNEP1 CTDNEP1 PEX12 PEX12 SHE SHE ABCD1 ABCD1 VWA5A VWA5A ABCD3 ABCD3 PEX1 PEX1 THEM4 THEM4 CNEP1R1 CNEP1R1 TYSND1 TYSND1 OR1J2 OR1J2 ACAD11 ACAD11 ABCD2 ABCD2 PXMP4 PXMP4 G3X8C4_BOVIN G3X8C4_BOVIN ZNF10 ZNF10 FOXD2 FOXD2 PEX14 PEX14 GNPAT GNPAT SLC27A2 SLC27A2 SCRT1 SCRT1 ACOT8 ACOT8 DBI DBI MTFP1 MTFP1 PEX10 PEX10 STMP1 STMP1 AGPS AGPS RNF150 RNF150 PEX5 PEX5 ACOT7 ACOT7 LGALS2 LGALS2 PEX16 PEX16 ENSBTAP00000072903 ENSBTAP00000072903 PEX26 PEX26 ACOT2-2 ACOT2-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THEM5Thioesterase superfamily member 5. (248 aa)
ATAD1ATPase family AAA domain-containing protein 1; ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity). (361 aa)
ETFBKMTElectron transfer flavoprotein subunit beta lysine methyltransferase. (266 aa)
PEX3Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes (By similarity). (373 aa)
ACOT2Uncharacterized protein. (476 aa)
SNX15Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN (By similarity). (345 aa)
ACOT4Uncharacterized protein. (424 aa)
SCP2Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. (543 aa)
PEX2Peroxisomal biogenesis factor 2. (305 aa)
AP1ARAdaptor related protein complex 1 associated regulatory protein. (302 aa)
PEX13Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins (By similarity). (403 aa)
PEX6Peroxisomal biogenesis factor 6. (980 aa)
EFCC1EF-hand and coiled-coil domain-containing protein 1. (597 aa)
PEX11APeroxisomal membrane protein 11A; May be involved in peroxisomal proliferation and may regulate peroxisomes division. May mediate binding of coatomer proteins to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface. (247 aa)
PXMP2Peroxisomal membrane protein 2; Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane. (294 aa)
PEX19Peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 (By similarity). (299 aa)
PEX11BPeroxisomal membrane protein 11B; Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface. (258 aa)
FAR1Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (515 aa)
TMEM100Transmembrane protein 100; Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor- dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open [...] (134 aa)
DNAL1Dynein light chain 1, axonemal. (433 aa)
LOC512541Uncharacterized protein. (416 aa)
LRRN4CLLRRN4 C-terminal-like protein. (232 aa)
LONP2Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. Belongs to the peptidase S16 family. (852 aa)
FAR2Fatty acyl-CoA reductase 2; Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates. It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates. (515 aa)
ACOT9Acyl-coenzyme A thioesterase 9, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs. (437 aa)
GDAP1Ganglioside-induced differentiation-associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission; Belongs to the GST superfamily. (358 aa)
PEX5LPeroxisomal biogenesis factor 5 like. (603 aa)
DBIL5Diazepam-binding inhibitor-like 5; May be involved in the energy metabolism of the mature sperm. (87 aa)
TMEM63CTransmembrane protein 63C. (804 aa)
PEX7Peroxisomal biogenesis factor 7. (323 aa)
ACBD5Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity); Belongs to the ATG37 family. (533 aa)
PEX11GPeroxisomal biogenesis factor 11 gamma. (240 aa)
CTDNEP1CTD nuclear envelope phosphatase 1; Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and [...] (244 aa)
PEX12Peroxisome assembly protein 12; Required for protein import into peroxisomes. (359 aa)
SHESrc homology 2 domain containing E. (522 aa)
ABCD1ATP-binding cassette, sub-family D (ALD), member 1. (737 aa)
VWA5AVon Willebrand factor A domain containing 5A. (785 aa)
ABCD3ATP binding cassette subfamily D member 3. (656 aa)
PEX1Peroxisomal biogenesis factor 1. (1281 aa)
THEM4Acyl-coenzyme A thioesterase THEM4; Has acyl-CoA thioesterase activity towards medium and long- chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism (By similarity). Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity (By similarity). (232 aa)
CNEP1R1Nuclear envelope phosphatase-regulatory subunit 1; Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplet [...] (125 aa)
TYSND1Trypsin domain containing 1. (568 aa)
OR1J2Olfactory receptor. (313 aa)
ACAD11Acyl-Coenzyme A dehydrogenase family, member 11. (781 aa)
ABCD2ATP binding cassette subfamily D member 2. (741 aa)
PXMP4Peroxisomal membrane protein 4; Belongs to the peroxisomal membrane protein PXMP2/4 family. (212 aa)
G3X8C4_BOVINUncharacterized protein. (247 aa)
ZNF10Zinc finger protein 10. (571 aa)
FOXD2Forkhead box D2. (486 aa)
PEX14Peroxisomal biogenesis factor 14. (389 aa)
GNPATDihydroxyacetone phosphate acyltransferase. (680 aa)
SLC27A2Solute carrier family 27 member 2. (633 aa)
SCRT1Uncharacterized protein. (352 aa)
ACOT8Acyl-CoA thioesterase 8. (337 aa)
DBIAcyl-CoA-binding protein; Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. (94 aa)
MTFP1Mitochondrial fission process 1. (171 aa)
PEX10Pex2_Pex12 domain-containing protein. (395 aa)
STMP1Uncharacterized protein. (137 aa)
AGPSAlkylglycerone-phosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. (658 aa)
RNF150Ring finger protein 150. (440 aa)
PEX5Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. (640 aa)
ACOT7Uncharacterized protein. (398 aa)
LGALS2Galectin. (130 aa)
PEX16Peroxisomal membrane protein PEX16; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 (By similarity); Belongs to the peroxin-16 family. (357 aa)
ENSBTAP00000072903Glutaredoxin domain-containing protein. (116 aa)
PEX26Peroxisomal biogenesis factor 26. (300 aa)
ACOT2-2ACOT2 protein. (464 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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