STRINGSTRING
INPP5E INPP5E TMEM107 TMEM107 ARL3 ARL3 RPGRIP1 RPGRIP1 ARL13B ARL13B NPHP3 NPHP3 TCTN2 TCTN2 UNC119B UNC119B NPHP1 NPHP1 TCTN3 TCTN3 IQCB1 IQCB1 UNC119 UNC119 TULP3 TULP3 CEP290 CEP290 TMEM216 TMEM216 B9D2 B9D2 NPHP4 NPHP4 RP2 RP2 MKS1 MKS1 C2CD6 C2CD6 TMEM67 TMEM67 CC2D2A CC2D2A G5E6L5_BOVIN G5E6L5_BOVIN TCTN1 TCTN1 PDE6D PDE6D TMEM237 TMEM237 RPGRIP1L RPGRIP1L TMEM231 TMEM231 RPGR RPGR B9D1 B9D1 GPR161 GPR161 AHI1 AHI1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INPP5EInositol polyphosphate-5-phosphatase E. (656 aa)
TMEM107Transmembrane protein 107. (140 aa)
ARL3ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] (198 aa)
RPGRIP1X-linked retinitis pigmentosa GTPase regulator-interacting protein 1; May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells; Belongs to the RPGRIP1 family. (1213 aa)
ARL13BADP ribosylation factor like GTPase 13B. (429 aa)
NPHP3Nephrocystin 3. (1331 aa)
TCTN2Tectonic family member 2. (665 aa)
UNC119BUnc-119 lipid binding chaperone B. (254 aa)
NPHP1Nephrocystin 1. (686 aa)
TCTN3Tectonic family member 3. (599 aa)
IQCB1IQ motif containing B1. (598 aa)
UNC119Protein unc-119 homolog A; Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Proba [...] (240 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (478 aa)
CEP290Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. Required for the correct localization of ciliary and phototransduction proteins in retinal photorecepto [...] (1453 aa)
TMEM216Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. (141 aa)
B9D2B9 domain-containing protein 2; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. (175 aa)
NPHP4Nephrocystin 4. (1430 aa)
RP2Protein XRP2; Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. (350 aa)
MKS1MKS transition zone complex subunit 1. (558 aa)
C2CD6C2 calcium dependent domain containing 6. (1847 aa)
TMEM67Uncharacterized protein. (996 aa)
CC2D2ACoiled-coil and C2 domain containing 2A. (1620 aa)
G5E6L5_BOVINUncharacterized protein. (807 aa)
TCTN1Tectonic family member 1. (588 aa)
PDE6DRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (By similarity). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. [...] (160 aa)
TMEM237Transmembrane protein 237; Component of the transition zone in primary cilia. Required for ciliogenesis (By similarity); Belongs to the TMEM237 family. (434 aa)
RPGRIP1LRPGRIP1 like. (1270 aa)
TMEM231Transmembrane protein 231; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). (348 aa)
RPGRUncharacterized protein. (732 aa)
B9D1B9 domain containing 1. (239 aa)
GPR161G protein-coupled receptor 161; Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signalin [...] (573 aa)
AHI1Abelson helper integration site 1. (1172 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.