STRINGSTRING
CCDC14 CCDC14 POC1B POC1B CCDC112 CCDC112 CEP89 CEP89 CEP250 CEP250 CEP63 CEP63 CEP350 CEP350 PPP1R35 PPP1R35 CEP135 CEP135 CEP19 CEP19 RTTN RTTN CEP97 CEP97 FGFR1OP FGFR1OP ODF2 ODF2 KIAA0753 KIAA0753 WRAP73 WRAP73 CENPJ CENPJ STIL STIL FBF1 FBF1 SSX2IP SSX2IP LRRC45 LRRC45 CEP120 CEP120 PLK4 PLK4 SPICE1 SPICE1 CETN1 CETN1 CCDC66 CCDC66 SCLT1 SCLT1 C2CD3-2 C2CD3-2 CCDC120 CCDC120 KIF2A KIF2A CEP72 CEP72 OFD1 OFD1 CEP192 CEP192 PCM1 PCM1 CEP131 CEP131 CEP128 CEP128 SASS6 SASS6 CCP110 CCP110 CNTLN CNTLN TEX9 TEX9 PCNT PCNT CCDC68 CCDC68 CEP152 CEP152 CEP170 CEP170 KIF24 KIF24 CEP164 CEP164 C2CD3 C2CD3 CEP83 CEP83 POC1A POC1A NIN NIN POC5 POC5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCDC14Coiled-coil domain containing 14. (941 aa)
POC1BPOC1 centriolar protein B. (478 aa)
CCDC112Coiled-coil domain containing 112. (523 aa)
CEP89Centrosomal protein 89. (771 aa)
CEP250Centrosomal protein 250. (2434 aa)
CEP63Centrosomal protein 63. (705 aa)
CEP350Centrosomal protein 350. (3114 aa)
PPP1R35Protein phosphatase 1 regulatory subunit 35; Inhibits PPP1CA phosphatase activity. (266 aa)
CEP135Centrosomal protein 135. (1139 aa)
CEP19Centrosomal protein of 19 kDa; Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring at centrosomes. (163 aa)
RTTNRotatin. (2229 aa)
CEP97Centrosomal protein 97. (858 aa)
FGFR1OPFGFR1 oncogene partner; Required for anchoring microtubules to the centrosomes. Required for ciliation. (399 aa)
ODF2Outer dense fiber protein 2; Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to th [...] (873 aa)
KIAA0753KIAA0753. (940 aa)
WRAP73WD repeat containing, antisense to TP73. (458 aa)
CENPJCentromere protein J. (1354 aa)
STILSTIL centriolar assembly protein. (1288 aa)
FBF1Fas binding factor 1. (1119 aa)
SSX2IPSynovial sarcoma, X breakpoint 2 interacting protein. (614 aa)
LRRC45Leucine rich repeat containing 45. (670 aa)
CEP120Centrosomal protein of 120 kDa; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. May play a role in centriole duplication during mitosis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK [...] (987 aa)
PLK4Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit [...] (893 aa)
SPICE1Spindle and centriole-associated protein 1; Regulator required for centriole duplication. for proper bipolar spindle formation and chromosome congression in mitosis (By similarity). (860 aa)
CETN1Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation (By similarity); Belongs to the centrin family. (172 aa)
CCDC66Coiled-coil domain containing 66. (977 aa)
SCLT1Sodium channel and clathrin linker 1. (701 aa)
C2CD3-2C2 domain containing 3 centriole elongation regulator. (1587 aa)
CCDC120Coiled-coil domain containing 120. (662 aa)
KIF2AKinesin-like protein KIF2A; Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (By similarity). (744 aa)
CEP72Centrosomal protein 72. (634 aa)
OFD1LisH domain-containing protein. (980 aa)
CEP192Centrosomal protein 192. (2493 aa)
PCM1Pericentriolar material 1. (2168 aa)
CEP131Centrosomal protein 131. (1154 aa)
CEP128Centrosomal protein 128. (1100 aa)
SASS6SAS-6 centriolar assembly protein. (698 aa)
CCP110Centriolar coiled-coil protein 110. (1006 aa)
CNTLNCentlein. (1406 aa)
TEX9Testis expressed 9. (386 aa)
PCNTPericentrin. (3139 aa)
CCDC68Coiled-coil domain containing 68. (335 aa)
CEP152Centrosomal protein 152. (1742 aa)
CEP170Centrosomal protein 170. (1585 aa)
KIF24Kinesin family member 24; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1403 aa)
CEP164Centrosomal protein 164. (1898 aa)
C2CD3Uncharacterized protein. (364 aa)
CEP83Centrosomal protein 83. (700 aa)
POC1APOC1 centriolar protein homolog A; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation (By similarity). (399 aa)
NINNinein. (2167 aa)
POC5POC5 centriolar protein. (575 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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