STRINGSTRING
POC1B POC1B CEP63 CEP63 CEP135 CEP135 CENPJ CENPJ STIL STIL CEP120 CEP120 PLK4 PLK4 SPICE1 SPICE1 CETN1 CETN1 CEP192 CEP192 SASS6 SASS6 PCNT PCNT CEP152 CEP152 POC1A POC1A POC5 POC5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POC1BPOC1 centriolar protein B. (478 aa)
CEP63Centrosomal protein 63. (705 aa)
CEP135Centrosomal protein 135. (1139 aa)
CENPJCentromere protein J. (1354 aa)
STILSTIL centriolar assembly protein. (1288 aa)
CEP120Centrosomal protein of 120 kDa; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. May play a role in centriole duplication during mitosis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK [...] (987 aa)
PLK4Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit [...] (893 aa)
SPICE1Spindle and centriole-associated protein 1; Regulator required for centriole duplication. for proper bipolar spindle formation and chromosome congression in mitosis (By similarity). (860 aa)
CETN1Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation (By similarity); Belongs to the centrin family. (172 aa)
CEP192Centrosomal protein 192. (2493 aa)
SASS6SAS-6 centriolar assembly protein. (698 aa)
PCNTPericentrin. (3139 aa)
CEP152Centrosomal protein 152. (1742 aa)
POC1APOC1 centriolar protein homolog A; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation (By similarity). (399 aa)
POC5POC5 centriolar protein. (575 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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