Your Input: | |
| | GRWD1 | Glutamate-rich WD repeat-containing protein 1; Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness. (446 aa) |
| | RSL24D1 | Probable ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity). (163 aa) |
| | NIP7 | 60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (180 aa) |
| | UTP11 | U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (253 aa) |
| | DDX10 | RNA helicase. (876 aa) |
| | FBL | Fibrillarin. (322 aa) |
| | NSA2 | Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). (260 aa) |
| | GCC1 | GRIP and coiled-coil domain containing 1. (775 aa) |
| | IMP4 | U3 small nucleolar ribonucleoprotein protein IMP4; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity). (291 aa) |
| | UTP20 | UTP20 small subunit processome component. (2778 aa) |
| | NOL6 | Nucleolar protein 6. (1146 aa) |
| | DDX24 | DEAD-box helicase 24. (852 aa) |
| | GNL2 | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (732 aa) |
| | PMEL | Melanocyte protein PMEL; Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures (By similarity). (649 aa) |
| | TSR1 | TSR1 ribosome maturation factor. (804 aa) |
| | PWP1 | Periodic tryptophan protein 1 homolog; Chromatin-associated factor that regulates transcription (By similarity). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (By similarity). Regulates the epigenetic status of rDNA (By similarity). Belongs to the WD repeat PWP1 family. (500 aa) |
| | SDAD1 | Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (687 aa) |
| | SNU13 | NHP2-like protein 1, N-terminally processed; Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. (128 aa) |
| | RTCA | RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity); Belongs to the RNA 3'-terminal cyclase family. [...] (366 aa) |
| | UTP4 | UTP4 small subunit processome component. (686 aa) |
| | ESF1 | ESF1 nucleolar pre-rRNA processing protein homolog. (856 aa) |
| | DDX55 | ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase. (685 aa) |
| | PES1 | Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family. (618 aa) |
| | DNTTIP2 | Deoxynucleotidyltransferase terminal-interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (By similarity). (766 aa) |
| | RPF1 | Ribosome production factor 1 homolog. (349 aa) |
| | WDR74 | WD repeat-containing protein 74; Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit. Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL. (385 aa) |
| | ZNF593 | Zinc finger protein 593. (134 aa) |
| | NGDN | Neuroguidin; Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs. (315 aa) |
| | PDCD11 | Protein RRP5 homolog; Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA (By similarity). (1874 aa) |
| | BOP1 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (753 aa) |
| | RRP15 | RRP15-like protein. (286 aa) |
| | MPHOSPH10 | U3 small nucleolar ribonucleoprotein protein MPP10; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing; Belongs to the MPP10 family. (686 aa) |
| | BYSL | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. (435 aa) |
| | DDX52 | Probable ATP-dependent RNA helicase DDX52; Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily. (596 aa) |
| | PA2G4 | Proliferation-associated 2G4, 38kDa. (394 aa) |
| | DDX56 | Probable ATP-dependent RNA helicase DDX56; May play a role in later stages of the processing of the pre- ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity (By similarity); Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily. (546 aa) |
| | PNO1 | RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA. Belongs to the PNO1 family. (252 aa) |
| | ABT1 | Activator of basal transcription 1; Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity). (275 aa) |
| | EIF6 | Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity (By similarity). In tissues responsive to [...] (248 aa) |
| | SURF6 | Surfeit locus protein 6; Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity). Belongs to the SURF6 family. (353 aa) |
| | KRR1 | KRR1 small subunit processome component homolog; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity). (382 aa) |
| | RIOK2 | RIO kinase 2. (551 aa) |
| | DIMT1 | Probable dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. (313 aa) |
| | NOC4L | Nucleolar complex associated 4 homolog. (516 aa) |
| | MRTO4 | mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (239 aa) |
| | EMG1 | EMG1 N1-specific pseudouridine methyltransferase. (347 aa) |
| | UTP14A | U3 small nucleolar RNA-associated protein 14 homolog A; May be required for ribosome biogenesis. (770 aa) |
| | PUM3 | Pumilio RNA binding family member 3. (647 aa) |
| | P2RY11 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (374 aa) |
| | RSL1D1 | Ribosomal L1 domain-containing protein 1; Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage; Belongs to the universal ribosomal protein uL1 family. Highly divergent. (482 aa) |
| | NOP2 | NOP2 nucleolar protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (820 aa) |
| | GTPBP4 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (634 aa) |
| | WDR12 | Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (423 aa) |
| | UTP6 | UTP6 small subunit processome component. (598 aa) |
| | NOL11 | Nucleolar protein 11; Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b (By similarity). (718 aa) |
| | NMD3 | 60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. (503 aa) |
| | ZNF622 | Zinc finger protein 622. (506 aa) |
| | NOC2L | Nucleolar complex protein 2 homolog; Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis (By similarity). (746 aa) |
| | RRS1 | Ribosome biogenesis regulatory protein homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. (365 aa) |
| | NAT10 | RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1025 aa) |
| | WDR46 | Chromosome 6 open reading frame 11. (605 aa) |
| | RBM28 | RNA binding motif protein 28. (751 aa) |
| | BUD23 | Probable 18S rRNA (guanine-N(7))-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA- modifying catalytic activity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactiva [...] (281 aa) |
| | RRP1B | Ribosomal RNA processing 1B. (737 aa) |
| | WDR43 | WD repeat domain 43. (681 aa) |
| | NOP56 | Nucleolar protein 56; Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity). (596 aa) |
| | WDR3 | WD repeat domain 3. (943 aa) |
| | FCF1 | rRNA-processing protein FCF1 homolog; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly; Belongs to the UTP23/FCF1 family. FCF1 subfamily. (198 aa) |
| | DHX37 | DEAH-box helicase 37. (1155 aa) |
| | UTP18 | UTP18 small subunit processome component. (564 aa) |
| | UTP25 | UTP25 small subunit processor component. (753 aa) |
| | FTSJ3 | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (836 aa) |
| | DCAF13 | DDB1 and CUL4 associated factor 13. (445 aa) |
| | EBNA1BP2 | EBNA1 binding protein 2. (305 aa) |
| | AATF | Apoptosis antagonizing transcription factor. (568 aa) |
| | NSUN6 | NOP2/Sun RNA methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (408 aa) |
| | NIFK | MKI67 FHA domain-interacting nucleolar phosphoprotein. (296 aa) |
| | GNL1 | G protein nucleolar 1 (putative). (607 aa) |
| | UTP15 | U3 small nucleolar RNA-associated protein 15 homolog; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. (519 aa) |
| | DDX31 | RNA helicase. (736 aa) |
| | RRP1 | Ribosomal RNA processing 1 homolog (S. cerevisiae). (446 aa) |
| | NOP53 | NOP53 ribosome biogenesis factor. (534 aa) |
| | NOM1 | Nucleolar protein with MIF4G domain 1. (847 aa) |
| | NOP14 | NOP14 nucleolar protein. (869 aa) |
| | DDX18 | RNA helicase. (670 aa) |
| | RRP36 | Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA; Belongs to the RRP36 family. (246 aa) |
| | NOP9 | NOP9 nucleolar protein. (636 aa) |
| | MAK16 | Protein MAK16 homolog. (298 aa) |
| | BMS1 | BMS1 ribosome biogenesis factor. (1284 aa) |
| | MCC | MCC regulator of WNT signaling pathway. (829 aa) |
| | DDX27 | Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA. (765 aa) |
| | UTP3 | UTP3, small subunit processome component. (474 aa) |
| | F1MSX0_BOVIN | RNA helicase. (689 aa) |
| | CEBPZ | CCAAT enhancer binding protein zeta. (1060 aa) |
| | RBM34 | Uncharacterized protein. (428 aa) |
| | HEATR1 | HEAT repeat containing 1. (2142 aa) |
| | FBLL1 | Fibrillarin like 1. (294 aa) |
| | BRIX1 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. (353 aa) |
| | NOL10 | Nucleolar protein 10. (832 aa) |
| | DDX47 | Probable ATP-dependent RNA helicase DDX47; Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors (By similarity). Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily. (458 aa) |
| | DDX54 | ATP-dependent RNA helicase DDX54; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (945 aa) |
| | LSG1 | Large subunit GTPase 1 homolog; GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (By similarity). (652 aa) |
| | ENSBTAP00000058753 | PINc domain-containing protein. (165 aa) |
| | DDX49 | DEAD-box helicase 49; Belongs to the DEAD box helicase family. (483 aa) |
| | TBL3 | Transducin beta-like protein 3. (839 aa) |
| | NOP58 | NOP58 ribonucleoprotein. (552 aa) |
| | ENSBTAP00000061090 | Uncharacterized protein. (299 aa) |
| | RRP12 | Ribosomal RNA processing 12 homolog. (1297 aa) |
| | WDR36 | WD_REPEATS_REGION domain-containing protein. (895 aa) |
| | ENSBTAP00000065831 | Uncharacterized protein. (190 aa) |
| | ENSBTAP00000066079 | OBG-type G domain-containing protein. (174 aa) |
| | GNL3 | G protein nucleolar 3. (548 aa) |
| | RRP7A | Uncharacterized protein. (280 aa) |
| | ENSBTAP00000067167 | Uncharacterized protein. (608 aa) |
| | NOL12 | Nucleolar protein 12; May bind to 28S rRNA. (213 aa) |
| | LOC112448582 | WD repeat domain 36. (864 aa) |
| | NOC3L | Nucleolar complex protein 3 homolog. (799 aa) |
| | LOC112445710 | BP28CT domain-containing protein. (328 aa) |
| | WDR75 | WD repeat domain 75. (856 aa) |
| | LTV1 | Protein LTV1 homolog; Belongs to the LTV1 family. (476 aa) |
| | RRP9 | Ribosomal RNA processing 9, U3 small nucleolar RNA binding protein. (521 aa) |
| | NOB1 | RNA-binding protein NOB1; May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity). (413 aa) |
| | RBM19 | RNA binding motif protein 19. (947 aa) |
| | ENSBTAP00000071182 | UPF0113_N domain-containing protein. (145 aa) |
| | PPAN | Brix domain-containing protein. (502 aa) |
| | PWP2 | WD_REPEATS_REGION domain-containing protein. (947 aa) |
| | GNL3L | Guanine nucleotide-binding protein-like 3-like protein; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal proces [...] (644 aa) |
| | RPF2 | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family. (323 aa) |
| | RCL1 | RNA 3'-terminal phosphate cyclase-like protein; Does not have cyclase activity. Plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity); Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily. (408 aa) |
