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| | MFAP5 | Microfibrillar-associated protein 5; May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (By similarity). Component of the elastin-associated microfibrils (By similarity). (249 aa) |
| | PLOD3 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (751 aa) |
| | COL11A2 | Collagen alpha-2(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. (1736 aa) |
| | ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif 1. (970 aa) |
| | BMP1 | Metalloendopeptidase. (988 aa) |
| | LUM | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (342 aa) |
| | PLOD1 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys- Gly- sequences in collagens (By similarity). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (By similarity). (726 aa) |
| | TMEM38B | Trimeric intracellular cation channel type B; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. (291 aa) |
| | P4HB | Protein disulfide-isomerase; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chape [...] (565 aa) |
| | MFAP4 | Microfibril-associated glycoprotein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance. (255 aa) |
| | LOXL2 | Lysyl oxidase homolog 2; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys- 9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member o [...] (774 aa) |
| | P4HA3 | Prolyl 4-hydroxylase subunit alpha-3; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. (544 aa) |
| | NID1 | NID1 protein. (1241 aa) |
| | LOXL1 | Lysyl oxidase homolog 1; Active on elastin and collagen substrates. (592 aa) |
| | SERPINF1 | Pigment epithelium-derived factor; Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. (416 aa) |
| | MMP24 | Matrix metallopeptidase 24. (601 aa) |
| | COL5A3 | Collagen type V alpha 3 chain. (1745 aa) |
| | TIMP2 | Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family. (235 aa) |
| | FKBP10 | Peptidyl-prolyl cis-trans isomerase FKBP10; PPIases accelerate the folding of proteins during protein synthesis. (583 aa) |
| | COL6A1 | Collagen type VI alpha 1 chain. (1027 aa) |
| | COLGALT1 | Procollagen galactosyltransferase 1; Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen. By acting on collagen glycosylation, facilitates the formation of collagen triple helix. Also involved in the biosynthesis of collagen type IV. Belongs to the glycosyltransferase 25 family. (623 aa) |
| | COL6A6 | Collagen type VI alpha 6 chain. (2023 aa) |
| | MMP15 | Matrix metallopeptidase 15. (675 aa) |
| | COL1A1 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1463 aa) |
| | COL23A1 | Collagen type XXIII alpha 1 chain. (349 aa) |
| | COL14A1 | Collagen type XIV alpha 1 chain. (1800 aa) |
| | COL8A1 | Collagen type VIII alpha 1 chain. (745 aa) |
| | COL6A3 | Collagen type VI alpha 3 chain. (3132 aa) |
| | ADAMTS2 | A disintegrin and metalloproteinase with thrombospondin motifs 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity (By similarity). (1205 aa) |
| | MMP14 | Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which in [...] (720 aa) |
| | FBN2 | Fibrillin 2. (2912 aa) |
| | MMP25 | Matrix metallopeptidase 25. (557 aa) |
| | PYCR3 | Pyrroline-5-carboxylate reductase 3; Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline. (308 aa) |
| | PPIB | Peptidyl-prolyl cis-trans isomerase B; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. (216 aa) |
| | HSPG2 | Heparan sulfate proteoglycan 2. (4356 aa) |
| | P3H1 | Prolyl 3-hydroxylase 1. (736 aa) |
| | LOXL3 | Lysyl oxidase like 3. (752 aa) |
| | MMP2 | 72 kDa type IV collagenase; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta- type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3 [...] (661 aa) |
| | COL6A2 | Collagen type VI alpha 2 chain. (979 aa) |
| | COL12A1 | Collagen alpha-1(XII) chain. (3065 aa) |
| | TIMP4 | Metalloproteinase inhibitor 4; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family. (224 aa) |
| | LOXL4 | Lysyl oxidase homolog 4; May modulate the formation of a collagenous extracellular matrix. (757 aa) |
| | P3H2 | Prolyl 3-hydroxylase 2. (706 aa) |
| | COL11A1 | Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. (1817 aa) |
| | CRTAP | Cartilage associated protein. (401 aa) |
| | COL3A1 | Collagen alpha-1(III) chain. (1466 aa) |
| | LTBP2 | Latent-transforming growth factor beta-binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly. Belongs to the LTBP family. (1963 aa) |
| | MMP17 | Matrix metallopeptidase 17. (591 aa) |
| | PLOD2 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (762 aa) |
| | COL1A2 | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1364 aa) |
| | COL18A1 | Collagen type XVIII alpha 1 chain. (1514 aa) |
| | COL4A1 | Collagen alpha-1(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. (1669 aa) |
| | E1BHG5_BOVIN | Uncharacterized protein. (272 aa) |
| | P3H3 | Prolyl 3-hydroxylase 3. (725 aa) |
| | COL13A1 | Collagen type XIII alpha 1 chain. (685 aa) |
| | COL26A1 | Collagen type XXVI alpha 1 chain. (438 aa) |
| | P4HA1 | Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. (534 aa) |
| | COLGALT2 | Uncharacterized protein. (626 aa) |
| | MMP16 | Matrix metallopeptidase 16. (607 aa) |
| | ITGBL1 | Integrin subunit beta like 1. (496 aa) |
| | COL16A1 | Collagen type XVI alpha 1 chain. (1257 aa) |
| | COL5A1 | Collagen type V alpha 1 chain. (1847 aa) |
| | COL20A1 | Collagen type XX alpha 1 chain. (1342 aa) |
| | MMP8 | Matrix metallopeptidase 8. (470 aa) |
| | POSTN | Periostin. (836 aa) |
| | P4HA2 | Prolyl 4-hydroxylase subunit alpha 2. (535 aa) |
| | PRODH | Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. (600 aa) |
| | PRODH2 | Hydroxyproline dehydrogenase; Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L- hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis. (491 aa) |
| | ALDH4A1 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). (588 aa) |
| | COL6A5 | Collagen type VI alpha 5 chain. (2465 aa) |
| | MFAP2 | Microfibrillar-associated protein 2; Component of the elastin-associated microfibrils; Belongs to the MFAP family. (275 aa) |
| | COL4A2 | Collagen alpha-2(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Potently inhibits angiogenesis and tumor growth (By similarity). (1551 aa) |
| | ADAM12 | ADAM metallopeptidase domain 12. (979 aa) |
| | CHADL | Chondroadherin like. (767 aa) |
| | MMP12 | ZnMc domain-containing protein. (470 aa) |
| | COL15A1 | Collagen type XV alpha 1 chain. (1398 aa) |
| | COL27A1 | Collagen type XXVII alpha 1 chain. (1841 aa) |
| | FBLN5 | Fibulin-5; Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN. Belongs to the fibulin family. (461 aa) |
| | ADAMTSL4 | ADAMTS like 4. (1070 aa) |
| | LOC101904550 | Uncharacterized protein. (563 aa) |
| | FBN1 | Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] (2990 aa) |
| | COL4A5 | Collagen type IV alpha 5 chain. (1538 aa) |
| | VCAN | Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. (3381 aa) |
| | LOX | Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. (418 aa) |
| | ELN | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity); Belongs to the elastin family. (760 aa) |
| | PYCR1 | Pyrroline-5-carboxylate reductase 1, mitochondrial; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. Belongs to the pyrroline-5-carboxylate reductase family. (351 aa) |
| | FBLN1 | Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (706 aa) |
| | COL21A1 | VWFA domain-containing protein. (518 aa) |
| | COL5A2 | Collagen type V alpha 2 chain. (1336 aa) |
| | SERPINH1 | Serpin H1; Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen (By similarity). Belongs to the serpin family. (418 aa) |
| | COL4A6 | Collagen type IV alpha 6 chain. (1706 aa) |
| | ADAMTS17 | ADAM metallopeptidase with thrombospondin type 1 motif 17. (1336 aa) |
| | COL8A2 | Collagen type VIII alpha 2 chain. (704 aa) |
| | FBLN2 | Fibulin 2. (1207 aa) |
