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GRWD1 GRWD1 RSL24D1 RSL24D1 NIP7 NIP7 NSA2 NSA2 DDX24 DDX24 GNL2 GNL2 PWP1 PWP1 SDAD1 SDAD1 DDX55 DDX55 PES1 PES1 RPF1 RPF1 WDR74 WDR74 ZNF593 ZNF593 BOP1 BOP1 RRP15 RRP15 PA2G4 PA2G4 DDX56 DDX56 EIF6 EIF6 SURF6 SURF6 MRTO4 MRTO4 PUM3 PUM3 P2RY11 P2RY11 RSL1D1 RSL1D1 NOP2 NOP2 GTPBP4 GTPBP4 WDR12 WDR12 NMD3 NMD3 ZNF622 ZNF622 NOC2L NOC2L RRS1 RRS1 RBM28 RBM28 RRP1B RRP1B FTSJ3 FTSJ3 EBNA1BP2 EBNA1BP2 NSUN6 NSUN6 NIFK NIFK GNL1 GNL1 RRP1 RRP1 NOP53 NOP53 DDX18 DDX18 MAK16 MAK16 DDX27 DDX27 F1MSX0_BOVIN F1MSX0_BOVIN CEBPZ CEBPZ RBM34 RBM34 BRIX1 BRIX1 DDX54 DDX54 LSG1 LSG1 ENSBTAP00000066079 ENSBTAP00000066079 GNL3 GNL3 NOC3L NOC3L ENSBTAP00000071182 ENSBTAP00000071182 PPAN PPAN GNL3L GNL3L RPF2 RPF2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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GRWD1Glutamate-rich WD repeat-containing protein 1; Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness. (446 aa)
RSL24D1Probable ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity). (163 aa)
NIP760S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (180 aa)
NSA2Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). (260 aa)
DDX24DEAD-box helicase 24. (852 aa)
GNL2Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (732 aa)
PWP1Periodic tryptophan protein 1 homolog; Chromatin-associated factor that regulates transcription (By similarity). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (By similarity). Regulates the epigenetic status of rDNA (By similarity). Belongs to the WD repeat PWP1 family. (500 aa)
SDAD1Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (687 aa)
DDX55ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase. (685 aa)
PES1Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family. (618 aa)
RPF1Ribosome production factor 1 homolog. (349 aa)
WDR74WD repeat-containing protein 74; Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit. Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL. (385 aa)
ZNF593Zinc finger protein 593. (134 aa)
BOP1Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (753 aa)
RRP15RRP15-like protein. (286 aa)
PA2G4Proliferation-associated 2G4, 38kDa. (394 aa)
DDX56Probable ATP-dependent RNA helicase DDX56; May play a role in later stages of the processing of the pre- ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity (By similarity); Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily. (546 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity (By similarity). In tissues responsive to [...] (248 aa)
SURF6Surfeit locus protein 6; Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity). Belongs to the SURF6 family. (353 aa)
MRTO4mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (239 aa)
PUM3Pumilio RNA binding family member 3. (647 aa)
P2RY11G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (374 aa)
RSL1D1Ribosomal L1 domain-containing protein 1; Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage; Belongs to the universal ribosomal protein uL1 family. Highly divergent. (482 aa)
NOP2NOP2 nucleolar protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (820 aa)
GTPBP4Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (634 aa)
WDR12Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (423 aa)
NMD360S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. (503 aa)
ZNF622Zinc finger protein 622. (506 aa)
NOC2LNucleolar complex protein 2 homolog; Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis (By similarity). (746 aa)
RRS1Ribosome biogenesis regulatory protein homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. (365 aa)
RBM28RNA binding motif protein 28. (751 aa)
RRP1BRibosomal RNA processing 1B. (737 aa)
FTSJ3pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (836 aa)
EBNA1BP2EBNA1 binding protein 2. (305 aa)
NSUN6NOP2/Sun RNA methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (408 aa)
NIFKMKI67 FHA domain-interacting nucleolar phosphoprotein. (296 aa)
GNL1G protein nucleolar 1 (putative). (607 aa)
RRP1Ribosomal RNA processing 1 homolog (S. cerevisiae). (446 aa)
NOP53NOP53 ribosome biogenesis factor. (534 aa)
DDX18RNA helicase. (670 aa)
MAK16Protein MAK16 homolog. (298 aa)
DDX27Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA. (765 aa)
F1MSX0_BOVINRNA helicase. (689 aa)
CEBPZCCAAT enhancer binding protein zeta. (1060 aa)
RBM34Uncharacterized protein. (428 aa)
BRIX1Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. (353 aa)
DDX54ATP-dependent RNA helicase DDX54; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (945 aa)
LSG1Large subunit GTPase 1 homolog; GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (By similarity). (652 aa)
ENSBTAP00000066079OBG-type G domain-containing protein. (174 aa)
GNL3G protein nucleolar 3. (548 aa)
NOC3LNucleolar complex protein 3 homolog. (799 aa)
ENSBTAP00000071182UPF0113_N domain-containing protein. (145 aa)
PPANBrix domain-containing protein. (502 aa)
GNL3LGuanine nucleotide-binding protein-like 3-like protein; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal proces [...] (644 aa)
RPF2Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family. (323 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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