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GRWD1 | Glutamate-rich WD repeat-containing protein 1; Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness. (446 aa) | ||||
RSL24D1 | Probable ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity). (163 aa) | ||||
NIP7 | 60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (180 aa) | ||||
NSA2 | Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). (260 aa) | ||||
DDX24 | DEAD-box helicase 24. (852 aa) | ||||
GNL2 | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (732 aa) | ||||
PWP1 | Periodic tryptophan protein 1 homolog; Chromatin-associated factor that regulates transcription (By similarity). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (By similarity). Regulates the epigenetic status of rDNA (By similarity). Belongs to the WD repeat PWP1 family. (500 aa) | ||||
SDAD1 | Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (687 aa) | ||||
DDX55 | ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase. (685 aa) | ||||
PES1 | Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family. (618 aa) | ||||
RPF1 | Ribosome production factor 1 homolog. (349 aa) | ||||
WDR74 | WD repeat-containing protein 74; Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit. Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL. (385 aa) | ||||
ZNF593 | Zinc finger protein 593. (134 aa) | ||||
BOP1 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (753 aa) | ||||
RRP15 | RRP15-like protein. (286 aa) | ||||
PA2G4 | Proliferation-associated 2G4, 38kDa. (394 aa) | ||||
DDX56 | Probable ATP-dependent RNA helicase DDX56; May play a role in later stages of the processing of the pre- ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity (By similarity); Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily. (546 aa) | ||||
EIF6 | Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity (By similarity). In tissues responsive to [...] (248 aa) | ||||
SURF6 | Surfeit locus protein 6; Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity). Belongs to the SURF6 family. (353 aa) | ||||
MRTO4 | mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (239 aa) | ||||
PUM3 | Pumilio RNA binding family member 3. (647 aa) | ||||
P2RY11 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (374 aa) | ||||
RSL1D1 | Ribosomal L1 domain-containing protein 1; Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage; Belongs to the universal ribosomal protein uL1 family. Highly divergent. (482 aa) | ||||
NOP2 | NOP2 nucleolar protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (820 aa) | ||||
GTPBP4 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (634 aa) | ||||
WDR12 | Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (423 aa) | ||||
NMD3 | 60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. (503 aa) | ||||
ZNF622 | Zinc finger protein 622. (506 aa) | ||||
NOC2L | Nucleolar complex protein 2 homolog; Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis (By similarity). (746 aa) | ||||
RRS1 | Ribosome biogenesis regulatory protein homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. (365 aa) | ||||
RBM28 | RNA binding motif protein 28. (751 aa) | ||||
RRP1B | Ribosomal RNA processing 1B. (737 aa) | ||||
FTSJ3 | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (836 aa) | ||||
EBNA1BP2 | EBNA1 binding protein 2. (305 aa) | ||||
NSUN6 | NOP2/Sun RNA methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (408 aa) | ||||
NIFK | MKI67 FHA domain-interacting nucleolar phosphoprotein. (296 aa) | ||||
GNL1 | G protein nucleolar 1 (putative). (607 aa) | ||||
RRP1 | Ribosomal RNA processing 1 homolog (S. cerevisiae). (446 aa) | ||||
NOP53 | NOP53 ribosome biogenesis factor. (534 aa) | ||||
DDX18 | RNA helicase. (670 aa) | ||||
MAK16 | Protein MAK16 homolog. (298 aa) | ||||
DDX27 | Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA. (765 aa) | ||||
F1MSX0_BOVIN | RNA helicase. (689 aa) | ||||
CEBPZ | CCAAT enhancer binding protein zeta. (1060 aa) | ||||
RBM34 | Uncharacterized protein. (428 aa) | ||||
BRIX1 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. (353 aa) | ||||
DDX54 | ATP-dependent RNA helicase DDX54; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (945 aa) | ||||
LSG1 | Large subunit GTPase 1 homolog; GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (By similarity). (652 aa) | ||||
ENSBTAP00000066079 | OBG-type G domain-containing protein. (174 aa) | ||||
GNL3 | G protein nucleolar 3. (548 aa) | ||||
NOC3L | Nucleolar complex protein 3 homolog. (799 aa) | ||||
ENSBTAP00000071182 | UPF0113_N domain-containing protein. (145 aa) | ||||
PPAN | Brix domain-containing protein. (502 aa) | ||||
GNL3L | Guanine nucleotide-binding protein-like 3-like protein; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal proces [...] (644 aa) | ||||
RPF2 | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family. (323 aa) |