23 items (Bos taurus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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gene fusions

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Your Input:
	EPHA2	EPH receptor A2. (975 aa)
	EFNA1	Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] (205 aa)
	EPHB3	EPH receptor B3. (997 aa)
	EPHA3	EPH receptor A3. (984 aa)
	NGEF	Neuronal guanine nucleotide exchange factor. (616 aa)
	EPHA4	EPH receptor A4. (986 aa)
	EPHB1	EPH receptor B1. (984 aa)
	EFNB1	Ephrin-B1; Belongs to the ephrin family. (346 aa)
	EPHB2	EPH receptor B2. (965 aa)
	EFNA3	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (238 aa)
	EPHA10	EPH receptor A10. (1008 aa)
	EPHB6	Uncharacterized protein. (1007 aa)
	EFNA4	EFNA4 protein; Belongs to the ephrin family. (204 aa)
	EFNB2	Ephrin B2; Belongs to the ephrin family. (333 aa)
	EPHB4	EPH receptor B4. (987 aa)
	EPHA8	EPH receptor A8. (930 aa)
	EPHA7	EPH receptor A7. (998 aa)
	EFNA2	EFNA2 protein; Belongs to the ephrin family. (213 aa)
	ABL1	Tyrosine-protein kinase. (1151 aa)
	EFNB3	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (340 aa)
	EPHA5	EPH receptor A5. (1035 aa)
	EFNA5	Ephrin-A5; Belongs to the ephrin family. (228 aa)
	EPHA1	EPH receptor A1. (1014 aa)

Your Current Organism:

Bos taurus

NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	EPHA1	ENSBTAP00000058693	ENSBTAP00000071119	Tyrosine-protein kinase.	EPH receptor A1.	0.942
ABL1	EPHA2	ENSBTAP00000058693	ENSBTAP00000001080	Tyrosine-protein kinase.	EPH receptor A2.	0.946
ABL1	EPHA3	ENSBTAP00000058693	ENSBTAP00000008955	Tyrosine-protein kinase.	EPH receptor A3.	0.943
ABL1	EPHA4	ENSBTAP00000058693	ENSBTAP00000013238	Tyrosine-protein kinase.	EPH receptor A4.	0.470
ABL1	EPHA5	ENSBTAP00000058693	ENSBTAP00000065469	Tyrosine-protein kinase.	EPH receptor A5.	0.965
ABL1	EPHA7	ENSBTAP00000058693	ENSBTAP00000039368	Tyrosine-protein kinase.	EPH receptor A7.	0.917
ABL1	EPHA8	ENSBTAP00000058693	ENSBTAP00000037611	Tyrosine-protein kinase.	EPH receptor A8.	0.909
ABL1	EPHB1	ENSBTAP00000058693	ENSBTAP00000020455	Tyrosine-protein kinase.	EPH receptor B1.	0.912
ABL1	EPHB2	ENSBTAP00000058693	ENSBTAP00000026780	Tyrosine-protein kinase.	EPH receptor B2.	0.944
ABL1	EPHB3	ENSBTAP00000058693	ENSBTAP00000006988	Tyrosine-protein kinase.	EPH receptor B3.	0.945
ABL1	EPHB4	ENSBTAP00000058693	ENSBTAP00000037070	Tyrosine-protein kinase.	EPH receptor B4.	0.946
EFNA1	EFNA2	ENSBTAP00000004007	ENSBTAP00000049002	Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...]	EFNA2 protein; Belongs to the ephrin family.	0.517
EFNA1	EFNA3	ENSBTAP00000004007	ENSBTAP00000026958	Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...]	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	0.608
EFNA1	EFNA4	ENSBTAP00000004007	ENSBTAP00000033875	Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...]	EFNA4 protein; Belongs to the ephrin family.	0.538
EFNA1	EFNA5	ENSBTAP00000004007	ENSBTAP00000070454	Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...]	Ephrin-A5; Belongs to the ephrin family.	0.644
EFNA1	EFNB1	ENSBTAP00000004007	ENSBTAP00000020985	Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...]	Ephrin-B1; Belongs to the ephrin family.	0.679
EFNA1	EFNB2	ENSBTAP00000004007	ENSBTAP00000035226	Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...]	Ephrin B2; Belongs to the ephrin family.	0.680
EFNA1	EFNB3	ENSBTAP00000004007	ENSBTAP00000060225	Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...]	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	0.674
EFNA1	EPHA1	ENSBTAP00000004007	ENSBTAP00000071119	Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...]	EPH receptor A1.	0.990
EFNA1	EPHA10	ENSBTAP00000004007	ENSBTAP00000033182	Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...]	EPH receptor A10.	0.976

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