STRINGSTRING
CD68 CD68 GPNMB GPNMB MSR1 MSR1 CLEC4F CLEC4F CD207 CD207 IRF5 IRF5 MERTK MERTK GP2 GP2 CD209 CD209 CD1A CD1A FCGR1A FCGR1A OLFML3 OLFML3 CLEC4E CLEC4E CSF1R CSF1R SIGLEC1 SIGLEC1 TIMD4 TIMD4 CSF3R CSF3R CLEC1A CLEC1A ICAM3 ICAM3 VSIG4 VSIG4 CD163 CD163 CLEC5A CLEC5A CSF3 CSF3 CLEC6A CLEC6A FCER1G FCER1G GAS6 GAS6 SPN SPN P2RY12 P2RY12 CLEC10A CLEC10A MRC1 MRC1 CD5L CD5L CLEC4D CLEC4D CLEC12A CLEC12A CSF1 CSF1 IL34 IL34 ENSBTAP00000059637 ENSBTAP00000059637 LOC515418 LOC515418 ITGAX ITGAX TYRO3 TYRO3 ENSBTAP00000063132 ENSBTAP00000063132 PLA2R1 PLA2R1 CLEC4A CLEC4A CLEC7A CLEC7A LILRA4 LILRA4 CST7 CST7 CD83 CD83 MRC2 MRC2 FCGR3A FCGR3A TMEM119 TMEM119 PROS1 PROS1 FCGR2A FCGR2A SYK SYK AXL AXL LOC104969408 LOC104969408
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD68CD68 molecule. (335 aa)
GPNMBGlycoprotein (Transmembrane) nmb. (555 aa)
MSR1Macrophage scavenger receptor types I and II; Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). (453 aa)
CLEC4FC-type lectin domain family 4 member F. (607 aa)
CD207CD207 molecule. (329 aa)
IRF5Interferon regulatory factor 5; Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling (By similarity). (499 aa)
MERTKMER proto-oncogene, tyrosine kinase. (999 aa)
GP2Glycoprotein 2. (534 aa)
CD209DC-SIGN-like protein. (259 aa)
CD1AIg-like domain-containing protein. (346 aa)
FCGR1AUncharacterized protein. (349 aa)
OLFML3Olfactomedin-like protein 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes (By similarity); Belongs to the OLFML3 family. (506 aa)
CLEC4EC-type lectin domain family 4 member E. (211 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
SIGLEC1Sialic acid binding Ig like lectin 1. (1713 aa)
TIMD4T cell immunoglobulin and mucin domain containing 4. (340 aa)
CSF3RColony stimulating factor 3 receptor. (841 aa)
CLEC1AC-type lectin domain family 1 member A. (278 aa)
ICAM3Intercellular adhesion molecule 3; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages. Belongs to the immunoglobulin superfamily. ICAM family. (544 aa)
VSIG4V-set and immunoglobulin domain containing 4. (305 aa)
CD163Scavenger receptor cysteine-rich type 1 protein M130; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion [...] (1129 aa)
CLEC5AC-type lectin domain containing 5A. (195 aa)
CSF3Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes; Belongs to the IL-6 superfamily. (195 aa)
CLEC6AC-type lectin domain family 6 member A; Binds high-mannose carbohydrates in a Ca(2+)-dependent manner (By similarity). Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G a [...] (206 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma; Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functi [...] (85 aa)
GAS6Growth arrest specific 6. (671 aa)
SPNSPN protein. (482 aa)
P2RY12Purinergic receptor P2Y, G-protein coupled, 12. (339 aa)
CLEC10AC-type lectin domain containing 10A. (308 aa)
MRC1Mannose receptor C-type 1. (1441 aa)
CD5LCD5 molecule like. (451 aa)
CLEC4DC-type lectin domain family 4 member D. (213 aa)
CLEC12AC-type lectin domain family 12 member A. (286 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (575 aa)
IL34Interleukin-34; Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity). (234 aa)
ENSBTAP00000059637Ig-like domain-containing protein. (221 aa)
LOC515418Ig-like domain-containing protein. (347 aa)
ITGAXVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1154 aa)
TYRO3TYRO3 protein tyrosine kinase. (889 aa)
ENSBTAP00000063132Uncharacterized protein. (308 aa)
PLA2R1Soluble secretory phospholipase A2 receptor; Receptor for secretory phospholipase A2 (sPLA2). Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marro [...] (1633 aa)
CLEC4AC-type lectin domain family 4 member A. (237 aa)
CLEC7AC-type lectin domain family 7 member A; Lectin that functions as pattern receptor specific for beta- 1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity). Necessary for the TLR2- mediated inflammatory response and for TLR2-mediated activation of NF- kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does [...] (247 aa)
LILRA4Ig-like domain-containing protein. (220 aa)
CST7Cystatin F. (148 aa)
CD83Uncharacterized protein. (282 aa)
MRC2Mannose receptor C type 2. (1488 aa)
FCGR3ALow affinity immunoglobulin gamma Fc region receptor III; Is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Also mediates antibody-dependent cellular toxicity (By similarity). (257 aa)
TMEM119Transmembrane protein 119. (302 aa)
PROS1Vitamin K-dependent protein S; Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. (676 aa)
FCGR2AIg-like domain-containing protein. (335 aa)
SYKTyrosine-protein kinase. (628 aa)
AXLAXL receptor tyrosine kinase. (887 aa)
LOC104969408Envelope glycoprotein. (477 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.