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ISL1 ISL1 EMX1 EMX1 SP8 SP8 DBX1 DBX1 EMX2 EMX2 VSX1 VSX1 MYT1L MYT1L LHX4 LHX4 NEUROD2 NEUROD2 MNX1 MNX1 LHX6 LHX6 POU4F2 POU4F2 BARHL2 BARHL2 FOXD3 FOXD3 PAX3 PAX3 TLX3 TLX3 FOXN4 FOXN4 LHX2 LHX2 FOXP2 FOXP2 FOXA2 FOXA2 SIX6 SIX6 VSX2 VSX2 OTX2 OTX2 ZIC1 ZIC1 DLX1 DLX1 NEUROG2 NEUROG2 NES NES ASCL1 ASCL1 ISL2 ISL2 ATOH7 ATOH7 NR2F1 NR2F1 EVX1 EVX1 TBR1 TBR1 VAX1 VAX1 POU3F2 POU3F2 SOX10 SOX10 ZIC2 ZIC2 EN1 EN1 SIX3 SIX3 DLX2 DLX2 LHX3 LHX3 PAX2 PAX2 OLIG3 OLIG3 POU3F1 POU3F1 ONECUT1 ONECUT1 PTF1A PTF1A GSX2 GSX2 SOX11 SOX11 OLIG2 OLIG2 PAX6 PAX6 ONECUT2 ONECUT2 FOXP1 FOXP1 LMX1B LMX1B SALL2 SALL2 SATB2 SATB2 FOXG1 FOXG1 CUX1 CUX1 FOXP4 FOXP4 LMX1A LMX1A SOX3 SOX3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ISL1ISL LIM homeobox 1. (349 aa)
EMX1Empty spiracles homeobox 1. (288 aa)
SP8Sp8 transcription factor. (472 aa)
DBX1Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity); Belongs to the H2.0 homeobox family. (345 aa)
EMX2Homeobox protein EMX2; Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system (By similarity). (253 aa)
VSX1Visual system homeobox 1; Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster (By similarity). May regulate the activity of the LCR and the cone opsin genes at earlier stages of development (By similarity). Dispensable in early retinal development (By similarity). (365 aa)
MYT1LMyelin transcription factor 1-like. (1144 aa)
LHX4LIM homeobox 4. (390 aa)
NEUROD2Neurogenic differentiation factor. (382 aa)
MNX1Motor neuron and pancreas homeobox 1. (409 aa)
LHX6LIM homeobox 6. (392 aa)
POU4F2POU domain protein. (407 aa)
BARHL2BarH like homeobox 2. (380 aa)
FOXD3Forkhead box D3. (399 aa)
PAX3Paired box 3. (484 aa)
TLX3Homeobox domain-containing protein. (291 aa)
FOXN4Forkhead box N4. (518 aa)
LHX2LIM homeobox 2. (406 aa)
FOXP2Forkhead box P2. (745 aa)
FOXA2Forkhead box A2. (461 aa)
SIX6SIX homeobox 6. (222 aa)
VSX2Visual system homeobox 2. (361 aa)
OTX2Orthodenticle homeobox 2. (289 aa)
ZIC1Zic family member 1. (503 aa)
DLX1Distal-less homeobox 1. (255 aa)
NEUROG2Neurogenin 2. (270 aa)
NESNestin; Belongs to the intermediate filament family. (1798 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (219 aa)
ISL2ISL LIM homeobox 2. (359 aa)
ATOH7Atonal bHLH transcription factor 7. (152 aa)
NR2F1COUP transcription factor 1; Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG (By similarity). (424 aa)
EVX1Even-skipped homeobox 1. (404 aa)
TBR1T-box brain transcription factor 1. (682 aa)
VAX1Ventral anterior homeobox 1. (334 aa)
POU3F2POU domain protein. (438 aa)
SOX10SRY-box transcription factor 10. (469 aa)
ZIC2Zic family member 2. (525 aa)
EN1Homeobox protein engrailed-like. (400 aa)
SIX3SIX homeobox 3. (328 aa)
DLX2Distal-less homeobox 2. (331 aa)
LHX3LIM homeodomain 3 protein b isoform. (403 aa)
PAX2Paired box 2. (489 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
POU3F1POU domain protein. (451 aa)
ONECUT1One cut domain family member. (465 aa)
PTF1APancreas associated transcription factor 1a. (326 aa)
GSX2GS homeobox 2. (305 aa)
SOX11Transcription factor SOX. (451 aa)
OLIG2Oligodendrocyte transcription factor 2. (327 aa)
PAX6Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity); Belongs to the paired homeobox family. (436 aa)
ONECUT2One cut domain family member. (557 aa)
FOXP1Forkhead box protein P1; Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neur [...] (675 aa)
LMX1BLIM homeobox transcription factor 1 beta. (395 aa)
SALL2Spalt like transcription factor 2. (1099 aa)
SATB2DNA-binding protein SATB. (733 aa)
FOXG1Forkhead box G1. (490 aa)
CUX1Homeobox protein cut-like. (1648 aa)
FOXP4Forkhead box P4. (747 aa)
LMX1ALIM homeobox transcription factor 1 alpha. (382 aa)
SOX3SRY-box transcription factor 3. (451 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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