STRINGSTRING
ISL1 ISL1 DBX1 DBX1 VSX1 VSX1 LHX4 LHX4 MNX1 MNX1 POU4F2 POU4F2 BARHL2 BARHL2 TLX3 TLX3 FOXN4 FOXN4 LHX2 LHX2 FOXA2 FOXA2 SIX6 SIX6 VSX2 VSX2 OTX2 OTX2 ISL2 ISL2 ATOH7 ATOH7 EVX1 EVX1 VAX1 VAX1 EN1 EN1 SIX3 SIX3 LHX3 LHX3 PAX2 PAX2 OLIG3 OLIG3 ONECUT1 ONECUT1 PTF1A PTF1A ONECUT2 ONECUT2 LMX1B LMX1B LMX1A LMX1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ISL1ISL LIM homeobox 1. (349 aa)
DBX1Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity); Belongs to the H2.0 homeobox family. (345 aa)
VSX1Visual system homeobox 1; Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster (By similarity). May regulate the activity of the LCR and the cone opsin genes at earlier stages of development (By similarity). Dispensable in early retinal development (By similarity). (365 aa)
LHX4LIM homeobox 4. (390 aa)
MNX1Motor neuron and pancreas homeobox 1. (409 aa)
POU4F2POU domain protein. (407 aa)
BARHL2BarH like homeobox 2. (380 aa)
TLX3Homeobox domain-containing protein. (291 aa)
FOXN4Forkhead box N4. (518 aa)
LHX2LIM homeobox 2. (406 aa)
FOXA2Forkhead box A2. (461 aa)
SIX6SIX homeobox 6. (222 aa)
VSX2Visual system homeobox 2. (361 aa)
OTX2Orthodenticle homeobox 2. (289 aa)
ISL2ISL LIM homeobox 2. (359 aa)
ATOH7Atonal bHLH transcription factor 7. (152 aa)
EVX1Even-skipped homeobox 1. (404 aa)
VAX1Ventral anterior homeobox 1. (334 aa)
EN1Homeobox protein engrailed-like. (400 aa)
SIX3SIX homeobox 3. (328 aa)
LHX3LIM homeodomain 3 protein b isoform. (403 aa)
PAX2Paired box 2. (489 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
ONECUT1One cut domain family member. (465 aa)
PTF1APancreas associated transcription factor 1a. (326 aa)
ONECUT2One cut domain family member. (557 aa)
LMX1BLIM homeobox transcription factor 1 beta. (395 aa)
LMX1ALIM homeobox transcription factor 1 alpha. (382 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.