node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMP15 | DMRT1 | ENSBTAP00000056137 | ENSBTAP00000023667 | Bone morphogenetic protein 15; May be involved in follicular development. Seems to be an oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). | Doublesex and mab-3 related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promo [...] | 0.523 |
BMP15 | FIGLA | ENSBTAP00000056137 | ENSBTAP00000011723 | Bone morphogenetic protein 15; May be involved in follicular development. Seems to be an oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). | Folliculogenesis specific bHLH transcription factor. | 0.841 |
BMP15 | FOXL2 | ENSBTAP00000056137 | ENSBTAP00000041814 | Bone morphogenetic protein 15; May be involved in follicular development. Seems to be an oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). | Forkhead box protein L2; Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination (By similarity). Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells (By similarity). Suppresses ESR1- mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Activates SIRT1 transcription under cellular stress conditions (By similarity). Activates [...] | 0.715 |
BMP15 | GDF9 | ENSBTAP00000056137 | ENSBTAP00000012476 | Bone morphogenetic protein 15; May be involved in follicular development. Seems to be an oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). | Growth/differentiation factor 9; Required for ovarian folliculogenesis. | 0.865 |
BMP15 | LHX8 | ENSBTAP00000056137 | ENSBTAP00000025544 | Bone morphogenetic protein 15; May be involved in follicular development. Seems to be an oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). | LIM homeobox 8. | 0.583 |
BMP15 | NOBOX | ENSBTAP00000056137 | ENSBTAP00000012965 | Bone morphogenetic protein 15; May be involved in follicular development. Seems to be an oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). | NOBOX oogenesis homeobox. | 0.829 |
BMP15 | NR0B1 | ENSBTAP00000056137 | ENSBTAP00000020641 | Bone morphogenetic protein 15; May be involved in follicular development. Seems to be an oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). | Nuclear receptor subfamily 0 group B member 1. | 0.444 |
BMP15 | NR5A1 | ENSBTAP00000056137 | ENSBTAP00000011869 | Bone morphogenetic protein 15; May be involved in follicular development. Seems to be an oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). | Steroidogenic factor 1; Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phospholipi [...] | 0.438 |
BMP15 | YBX2 | ENSBTAP00000056137 | ENSBTAP00000060883 | Bone morphogenetic protein 15; May be involved in follicular development. Seems to be an oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). | Y-box binding protein 2. | 0.482 |
DMRT1 | BMP15 | ENSBTAP00000023667 | ENSBTAP00000056137 | Doublesex and mab-3 related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promo [...] | Bone morphogenetic protein 15; May be involved in follicular development. Seems to be an oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). | 0.523 |
DMRT1 | FIGLA | ENSBTAP00000023667 | ENSBTAP00000011723 | Doublesex and mab-3 related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promo [...] | Folliculogenesis specific bHLH transcription factor. | 0.492 |
DMRT1 | FOXL2 | ENSBTAP00000023667 | ENSBTAP00000041814 | Doublesex and mab-3 related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promo [...] | Forkhead box protein L2; Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination (By similarity). Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells (By similarity). Suppresses ESR1- mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Activates SIRT1 transcription under cellular stress conditions (By similarity). Activates [...] | 0.777 |
DMRT1 | NR0B1 | ENSBTAP00000023667 | ENSBTAP00000020641 | Doublesex and mab-3 related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promo [...] | Nuclear receptor subfamily 0 group B member 1. | 0.561 |
DMRT1 | NR5A1 | ENSBTAP00000023667 | ENSBTAP00000011869 | Doublesex and mab-3 related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promo [...] | Steroidogenic factor 1; Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phospholipi [...] | 0.675 |
FIGLA | BMP15 | ENSBTAP00000011723 | ENSBTAP00000056137 | Folliculogenesis specific bHLH transcription factor. | Bone morphogenetic protein 15; May be involved in follicular development. Seems to be an oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). | 0.841 |
FIGLA | DMRT1 | ENSBTAP00000011723 | ENSBTAP00000023667 | Folliculogenesis specific bHLH transcription factor. | Doublesex and mab-3 related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promo [...] | 0.492 |
FIGLA | FOXL2 | ENSBTAP00000011723 | ENSBTAP00000041814 | Folliculogenesis specific bHLH transcription factor. | Forkhead box protein L2; Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination (By similarity). Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells (By similarity). Suppresses ESR1- mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Activates SIRT1 transcription under cellular stress conditions (By similarity). Activates [...] | 0.699 |
FIGLA | GDF9 | ENSBTAP00000011723 | ENSBTAP00000012476 | Folliculogenesis specific bHLH transcription factor. | Growth/differentiation factor 9; Required for ovarian folliculogenesis. | 0.831 |
FIGLA | LHX8 | ENSBTAP00000011723 | ENSBTAP00000025544 | Folliculogenesis specific bHLH transcription factor. | LIM homeobox 8. | 0.833 |
FIGLA | LOC788372 | ENSBTAP00000011723 | ENSBTAP00000041532 | Folliculogenesis specific bHLH transcription factor. | Olfactory receptor. | 0.549 |