(53 nodes) SH2 domain superfamily, and Endophilin-A, SH3 domain network (Bos taurus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	YES1	Tyrosine-protein kinase. (541 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
	CRK	CRK proto-oncogene, adaptor protein. (304 aa)
	PIK3R5	Phosphoinositide-3-kinase regulatory subunit 5. (893 aa)
	SH3GL1	Endophilin-A2; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). Belongs to the endophilin family. (368 aa)
	LCP2	Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa). (532 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1243 aa)
	SHC3	SHC adaptor protein 3. (583 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	SHC4	Uncharacterized protein. (630 aa)
	SH3GL2	SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
	GRAP2	GRB2 related adaptor protein 2. (316 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (845 aa)
	SHC2	SHC adaptor protein 2. (584 aa)
	PIK3R6	Phosphoinositide-3-kinase regulatory subunit 6. (740 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity). (1291 aa)
	TNK1	Tyrosine kinase non receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (667 aa)
	SH3GL3	SH3 domain containing GRB2 like 3, endophilin A3. (347 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (508 aa)
	SHC1	SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). (583 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	SPRY1	Protein sprouty homolog 1; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. (319 aa)
	LAT	Linker for activation of T cells. (254 aa)
	BTK	Tyrosine-protein kinase. (659 aa)
	LOC526769	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (613 aa)
	ITK	Tyrosine-protein kinase. (620 aa)
	GRAP	GRB2-related adapter protein; Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing. (217 aa)
	SPRY2	Protein sprouty homolog 2; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. (315 aa)
	SH2D2A	SH2 domain containing 2A. (418 aa)
	VAV1	Proto-oncogene vav; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. (844 aa)
	FER	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (302 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1265 aa)
	HCK	Tyrosine-protein kinase. (558 aa)
	MATK	Tyrosine-protein kinase. (485 aa)
	CBL	Cbl proto-oncogene. (932 aa)
	CBLB	Cbl proto-oncogene B. (983 aa)
	SH2D1B	SH2 domain-containing protein. (133 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1073 aa)
	GAB2	GRB2 associated binding protein 2. (680 aa)
	CBLC	Cbl proto-oncogene C. (491 aa)
	TXK	Tyrosine-protein kinase. (527 aa)
	FGR	Tyrosine-protein kinase. (527 aa)
	SH3KBP1	SH3 domain containing kinase binding protein 1. (665 aa)
	BLNK	B cell linker. (501 aa)
	GAB1	GRB2-associated-binding protein 1; Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway. (751 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
	BCAR1	BCAR1 scaffold protein, Cas family member. (919 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (839 aa)

Your Current Organism:

Bos taurus

NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCAR1	CBL	ENSBTAP00000073626	ENSBTAP00000061310	BCAR1 scaffold protein, Cas family member.	Cbl proto-oncogene.	0.481
BCAR1	CRK	ENSBTAP00000073626	ENSBTAP00000007443	BCAR1 scaffold protein, Cas family member.	CRK proto-oncogene, adaptor protein.	0.996
BCAR1	CRKL	ENSBTAP00000073626	ENSBTAP00000055171	BCAR1 scaffold protein, Cas family member.	CRK like proto-oncogene, adaptor protein.	0.978
BCAR1	FGR	ENSBTAP00000073626	ENSBTAP00000069921	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein kinase.	0.426
BCAR1	GRB2	ENSBTAP00000073626	ENSBTAP00000006216	BCAR1 scaffold protein, Cas family member.	Growth factor receptor-bound protein 2.	0.607
BCAR1	HCK	ENSBTAP00000073626	ENSBTAP00000060992	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein kinase.	0.446
BCAR1	LYN	ENSBTAP00000073626	ENSBTAP00000026686	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein kinase.	0.445
BCAR1	PTK2B	ENSBTAP00000073626	ENSBTAP00000059391	BCAR1 scaffold protein, Cas family member.	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.975
BCAR1	PTPN11	ENSBTAP00000073626	ENSBTAP00000002653	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.413
BCAR1	RAPGEF1	ENSBTAP00000073626	ENSBTAP00000060297	BCAR1 scaffold protein, Cas family member.	Rap guanine nucleotide exchange factor 1.	0.882
BCAR1	SHC1	ENSBTAP00000073626	ENSBTAP00000026432	BCAR1 scaffold protein, Cas family member.	SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity).	0.530
BCAR1	SHC3	ENSBTAP00000073626	ENSBTAP00000015112	BCAR1 scaffold protein, Cas family member.	SHC adaptor protein 3.	0.420
BCAR1	YES1	ENSBTAP00000073626	ENSBTAP00000001995	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein kinase.	0.634
BCR	CBL	ENSBTAP00000065181	ENSBTAP00000061310	BCR activator of RhoGEF and GTPase.	Cbl proto-oncogene.	0.929
BCR	CRK	ENSBTAP00000065181	ENSBTAP00000007443	BCR activator of RhoGEF and GTPase.	CRK proto-oncogene, adaptor protein.	0.915
BCR	CRKL	ENSBTAP00000065181	ENSBTAP00000055171	BCR activator of RhoGEF and GTPase.	CRK like proto-oncogene, adaptor protein.	0.933
BCR	FER	ENSBTAP00000065181	ENSBTAP00000053563	BCR activator of RhoGEF and GTPase.	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.	0.615
BCR	GRB2	ENSBTAP00000065181	ENSBTAP00000006216	BCR activator of RhoGEF and GTPase.	Growth factor receptor-bound protein 2.	0.975
BCR	PIK3CG	ENSBTAP00000065181	ENSBTAP00000064044	BCR activator of RhoGEF and GTPase.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.	0.425
BCR	SHC1	ENSBTAP00000065181	ENSBTAP00000026432	BCR activator of RhoGEF and GTPase.	SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity).	0.902

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