STRINGSTRING
ATG101 ATG101 RB1CC1 RB1CC1 ULK2 ULK2 ATG14 ATG14 ULK1 ULK1 DGAT2 DGAT2 ATG13 ATG13 PIK3R4 PIK3R4 NRBF2 NRBF2 AMBRA1 AMBRA1 BECN2 BECN2 PIK3C3 PIK3C3 BECN1 BECN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATG101Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation. (218 aa)
RB1CC1RB1 inducible coiled-coil 1. (1589 aa)
ULK2Unc-51 like autophagy activating kinase 2. (569 aa)
ATG14Autophagy related 14. (492 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1034 aa)
DGAT2UV radiation resistance associated. (699 aa)
ATG13Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. (480 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
NRBF2Nuclear receptor binding factor 2. (288 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1268 aa)
BECN2Beclin 2. (439 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (895 aa)
BECN1Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] (471 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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