STRINGSTRING
GALC GALC B4GALNT1 B4GALNT1 UGT8 UGT8 NAGA NAGA ST3GAL5 ST3GAL5 HEXA HEXA NEU4 NEU4 GLB1 GLB1 ARSA ARSA GLA GLA NEU2 NEU2 B3GALT4 B3GALT4 NEU3 NEU3 CTSA CTSA LOC786974 LOC786974 HEXB HEXB A4GALT A4GALT GBGT1 GBGT1 GAL3ST1 GAL3ST1 ST3GAL2 ST3GAL2 ST8SIA1 ST8SIA1 NEU1 NEU1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GALCGalactosylceramidase. (690 aa)
B4GALNT1Beta-1,4 N-acetylgalactosaminyltransferase. (533 aa)
UGT8UDP glycosyltransferase 8; Belongs to the UDP-glycosyltransferase family. (541 aa)
NAGAAlpha-N-acetylgalactosaminidase; Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids (By similarity); Belongs to the glycosyl hydrolase 27 family. (411 aa)
ST3GAL5Lactosylceramide alpha-2,3-sialyltransferase; Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide). (419 aa)
HEXABeta-hexosaminidase subunit alpha; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. (529 aa)
NEU4Neuraminidase 4. (478 aa)
GLB1Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family. (653 aa)
ARSAArylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. (507 aa)
GLAAlpha-galactosidase. (439 aa)
NEU2Neuraminidase 2. (379 aa)
B3GALT4Hexosyltransferase. (378 aa)
NEU3Sialidase-3; Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates. Belongs to the glycosyl hydrolase 33 family. (428 aa)
CTSALysosomal protective protein 20 kDa chain; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins (By similarity). (478 aa)
LOC786974Beta-hexosaminidase. (544 aa)
HEXBBeta-hexosaminidase. (537 aa)
A4GALTAlpha 1,4-galactosyltransferase. (355 aa)
GBGT1Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1. (378 aa)
GAL3ST1Galactosylceramide sulfotransferase; Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of HSO3-3- galactosylceramide (sulfatide), a major lipid component of the myelin sheath and of HSO3-3-monogalactosylalkylacylglycerol (seminolipid), present in spermatocytes. Also acts on lactosylceramide, galactosyl 1- alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro) (By similarity). (423 aa)
ST3GAL2ST3 beta-galactoside alpha-2,3-sialyltransferase 2; Belongs to the glycosyltransferase 29 family. (350 aa)
ST8SIA1Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid. (356 aa)
NEU1Sialidase-1; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage (By similarity). (416 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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