STRINGSTRING
ENPP7 ENPP7 SPTLC1 SPTLC1 CERS4 CERS4 ASAH2 ASAH2 SGPP1 SGPP1 KDSR KDSR ACER1 ACER1 SMPD2 SMPD2 SPHK1 SPHK1 DEGS2 DEGS2 SMPD3 SMPD3 ACER2 ACER2 ASAH1 ASAH1 GBA2 GBA2 DEGS1 DEGS1 ORMDL3 ORMDL3 SPTSSA SPTSSA SPTLC3 SPTLC3 ZDHHC9 ZDHHC9 SMPD1 SMPD1 SPTLC2 SPTLC2 ORMDL2 ORMDL2 SMPD4 SMPD4 CERS1 CERS1 E1B9U6_BOVIN E1B9U6_BOVIN GOLGA7 GOLGA7 UGCG UGCG ACER3 ACER3 CERS3 CERS3 B4GALT6 B4GALT6 CERK CERK SGPL1 SGPL1 CERS2 CERS2 CERS5 CERS5 GBA GBA SGPP2 SGPP2 SGMS1 SGMS1 SPHK2 SPHK2 SPTSSB SPTSSB CERS6 CERS6 SGMS2 SGMS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase 7. (436 aa)
SPTLC1Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...] (473 aa)
CERS4Ceramide synthase 4; Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor. (393 aa)
ASAH2Neutral ceramidase. (776 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (445 aa)
KDSR3-ketodihydrosphingosine reductase; Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (332 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (612 aa)
SPHK1Sphingosine kinase 1. (489 aa)
DEGS2Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase. (323 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
ASAH1Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] (395 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (926 aa)
DEGS1Sphingolipid delta(4)-desaturase DES1; Has sphingolipid-delta-4-desaturase activity. Converts D- erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (By similarity); Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. (323 aa)
ORMDL3ORM1-like protein 3; Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity). (153 aa)
SPTSSASerine palmitoyltransferase small subunit A; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1- SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. Plays a role in MBOAT7 location to mitochondria-associated membranes (MAMs), may me involved in fatty acid remodeling phosphatidylinositol (PI). (68 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (549 aa)
ZDHHC9Palmitoyltransferase ZDHHC9; The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. (363 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2- diacylglycerolphosphoglycerol; Belongs to the acid sphingomyelinase family. (625 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (562 aa)
ORMDL2ORM1-like protein 2; Negative regulator of sphingolipid synthesis; Belongs to the ORM family. (153 aa)
SMPD4Sphingomyelin phosphodiesterase 4. (867 aa)
CERS1Ceramide synthase 1. (408 aa)
E1B9U6_BOVINUncharacterized protein. (432 aa)
GOLGA7Golgin subfamily A member 7; May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS (By similarity); Belongs to the ERF4 family. (137 aa)
UGCGUDP-glucose ceramide glucosyltransferase. (394 aa)
ACER3Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (267 aa)
CERS3Ceramide synthase 3. (387 aa)
B4GALT6Beta-1,4-galactosyltransferase 6. (382 aa)
CERKCeramide kinase. (535 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (577 aa)
CERS2Ceramide synthase 2; Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very- long (C22:0-C24:0) chain as acyl donor. (386 aa)
CERS5Ceramide synthase 5. (452 aa)
GBALysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] (536 aa)
SGPP2Sphingosine-1-phosphate phosphatase 2. (414 aa)
SGMS1Sphingomyelin synthase 1. (413 aa)
SPHK2Sphingosine kinase 2. (713 aa)
SPTSSBSerine palmitoyltransferase small subunit B; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference, complexes with this subunit showing a clear preference for longer acyl-CoAs. The SPTLC1-SPTLC2- SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (By similarity). (76 aa)
CERS6Ceramide synthase 6. (392 aa)
SGMS2Sphingomyelin synthase 2. (365 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.