STRINGSTRING
ENPP7 ENPP7 CERS4 CERS4 ASAH2 ASAH2 SGPP1 SGPP1 ACER1 ACER1 SMPD2 SMPD2 SPHK1 SPHK1 DEGS2 DEGS2 SMPD3 SMPD3 ACER2 ACER2 ASAH1 ASAH1 DEGS1 DEGS1 SMPD1 SMPD1 SMPD4 SMPD4 CERS1 CERS1 E1B9U6_BOVIN E1B9U6_BOVIN ACER3 ACER3 CERS3 CERS3 CERK CERK SGPL1 SGPL1 CERS2 CERS2 CERS5 CERS5 SGPP2 SGPP2 SGMS1 SGMS1 SPHK2 SPHK2 CERS6 CERS6 SGMS2 SGMS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase 7. (436 aa)
CERS4Ceramide synthase 4; Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor. (393 aa)
ASAH2Neutral ceramidase. (776 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (445 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (612 aa)
SPHK1Sphingosine kinase 1. (489 aa)
DEGS2Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase. (323 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
ASAH1Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] (395 aa)
DEGS1Sphingolipid delta(4)-desaturase DES1; Has sphingolipid-delta-4-desaturase activity. Converts D- erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (By similarity); Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. (323 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2- diacylglycerolphosphoglycerol; Belongs to the acid sphingomyelinase family. (625 aa)
SMPD4Sphingomyelin phosphodiesterase 4. (867 aa)
CERS1Ceramide synthase 1. (408 aa)
E1B9U6_BOVINUncharacterized protein. (432 aa)
ACER3Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (267 aa)
CERS3Ceramide synthase 3. (387 aa)
CERKCeramide kinase. (535 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (577 aa)
CERS2Ceramide synthase 2; Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very- long (C22:0-C24:0) chain as acyl donor. (386 aa)
CERS5Ceramide synthase 5. (452 aa)
SGPP2Sphingosine-1-phosphate phosphatase 2. (414 aa)
SGMS1Sphingomyelin synthase 1. (413 aa)
SPHK2Sphingosine kinase 2. (713 aa)
CERS6Ceramide synthase 6. (392 aa)
SGMS2Sphingomyelin synthase 2. (365 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.