STRINGSTRING
ENPP7 ENPP7 CERS4 CERS4 ASAH2 ASAH2 ACER1 ACER1 SMPD2 SMPD2 DEGS2 DEGS2 SMPD3 SMPD3 ACER2 ACER2 ASAH1 ASAH1 DEGS1 DEGS1 SMPD1 SMPD1 SMPD4 SMPD4 CERS1 CERS1 E1B9U6_BOVIN E1B9U6_BOVIN ACER3 ACER3 CERS3 CERS3 CERK CERK CERS2 CERS2 CERS5 CERS5 SGMS1 SGMS1 CERS6 CERS6 SGMS2 SGMS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase 7. (436 aa)
CERS4Ceramide synthase 4; Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor. (393 aa)
ASAH2Neutral ceramidase. (776 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (612 aa)
DEGS2Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase. (323 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
ASAH1Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] (395 aa)
DEGS1Sphingolipid delta(4)-desaturase DES1; Has sphingolipid-delta-4-desaturase activity. Converts D- erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (By similarity); Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. (323 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2- diacylglycerolphosphoglycerol; Belongs to the acid sphingomyelinase family. (625 aa)
SMPD4Sphingomyelin phosphodiesterase 4. (867 aa)
CERS1Ceramide synthase 1. (408 aa)
E1B9U6_BOVINUncharacterized protein. (432 aa)
ACER3Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (267 aa)
CERS3Ceramide synthase 3. (387 aa)
CERKCeramide kinase. (535 aa)
CERS2Ceramide synthase 2; Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very- long (C22:0-C24:0) chain as acyl donor. (386 aa)
CERS5Ceramide synthase 5. (452 aa)
SGMS1Sphingomyelin synthase 1. (413 aa)
CERS6Ceramide synthase 6. (392 aa)
SGMS2Sphingomyelin synthase 2. (365 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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