(5 nodes) Mixed, incl. mRNA 3-splice site recognition, and Initiation factor eIF-4 gamma, MA3 network (Bos taurus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Your Input:
	SYF2	SYF2 pre-mRNA splicing factor. (245 aa)
	SLU7	Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Belongs to the SLU7 family. (586 aa)
	DHX38	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily. (1227 aa)
	CDC40	Cell division cycle 40. (611 aa)
	CWC22	CWC22 spliceosome associated protein homolog. (900 aa)

Your Current Organism:

Bos taurus

NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC40	CWC22	ENSBTAP00000059117	ENSBTAP00000062978	Cell division cycle 40.	CWC22 spliceosome associated protein homolog.	0.997
CDC40	DHX38	ENSBTAP00000059117	ENSBTAP00000042866	Cell division cycle 40.	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.	0.997
CDC40	SLU7	ENSBTAP00000059117	ENSBTAP00000011131	Cell division cycle 40.	Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Belongs to the SLU7 family.	0.995
CDC40	SYF2	ENSBTAP00000059117	ENSBTAP00000002165	Cell division cycle 40.	SYF2 pre-mRNA splicing factor.	0.997
CWC22	CDC40	ENSBTAP00000062978	ENSBTAP00000059117	CWC22 spliceosome associated protein homolog.	Cell division cycle 40.	0.997
CWC22	DHX38	ENSBTAP00000062978	ENSBTAP00000042866	CWC22 spliceosome associated protein homolog.	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.	0.991
CWC22	SLU7	ENSBTAP00000062978	ENSBTAP00000011131	CWC22 spliceosome associated protein homolog.	Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Belongs to the SLU7 family.	0.997
CWC22	SYF2	ENSBTAP00000062978	ENSBTAP00000002165	CWC22 spliceosome associated protein homolog.	SYF2 pre-mRNA splicing factor.	0.931
DHX38	CDC40	ENSBTAP00000042866	ENSBTAP00000059117	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.	Cell division cycle 40.	0.997
DHX38	CWC22	ENSBTAP00000042866	ENSBTAP00000062978	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.	CWC22 spliceosome associated protein homolog.	0.991
DHX38	SLU7	ENSBTAP00000042866	ENSBTAP00000011131	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.	Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Belongs to the SLU7 family.	0.988
DHX38	SYF2	ENSBTAP00000042866	ENSBTAP00000002165	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.	SYF2 pre-mRNA splicing factor.	0.994
SLU7	CDC40	ENSBTAP00000011131	ENSBTAP00000059117	Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Belongs to the SLU7 family.	Cell division cycle 40.	0.995
SLU7	CWC22	ENSBTAP00000011131	ENSBTAP00000062978	Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Belongs to the SLU7 family.	CWC22 spliceosome associated protein homolog.	0.997
SLU7	DHX38	ENSBTAP00000011131	ENSBTAP00000042866	Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Belongs to the SLU7 family.	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.	0.988
SLU7	SYF2	ENSBTAP00000011131	ENSBTAP00000002165	Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Belongs to the SLU7 family.	SYF2 pre-mRNA splicing factor.	0.991
SYF2	CDC40	ENSBTAP00000002165	ENSBTAP00000059117	SYF2 pre-mRNA splicing factor.	Cell division cycle 40.	0.997
SYF2	CWC22	ENSBTAP00000002165	ENSBTAP00000062978	SYF2 pre-mRNA splicing factor.	CWC22 spliceosome associated protein homolog.	0.931
SYF2	DHX38	ENSBTAP00000002165	ENSBTAP00000042866	SYF2 pre-mRNA splicing factor.	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.	0.994
SYF2	SLU7	ENSBTAP00000002165	ENSBTAP00000011131	SYF2 pre-mRNA splicing factor.	Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Belongs to the SLU7 family.	0.991

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