STRINGSTRING
MEIG1 MEIG1 LOC617486 LOC617486 SNTN SNTN DENND2D DENND2D LDLRAD1 LDLRAD1 CDHR3 CDHR3 DEUP1 DEUP1 CCNO CCNO MCIDAS MCIDAS FOXJ1 FOXJ1 SHISA8 SHISA8 RFX2 RFX2 PHYHIPL PHYHIPL PIFO PIFO CHI3L2 CHI3L2 CEP78 CEP78
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MEIG1Meiosis expressed gene 1 protein homolog; Essential for spermiogenesis; Belongs to the MEIG1 family. (111 aa)
LOC617486Protein pitchfork; During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle- dependent manner (By similarity). (192 aa)
SNTNSentan; May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules. (147 aa)
DENND2DDENN domain containing 2D. (478 aa)
LDLRAD1Low density lipoprotein receptor class A domain containing 1. (206 aa)
CDHR3Cadherin related family member 3. (856 aa)
DEUP1Deuterosome assembly protein 1. (436 aa)
CCNOCyclin O; Belongs to the cyclin family. (351 aa)
MCIDASMulticilin; Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway. Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1. (374 aa)
FOXJ1Forkhead box J1. (421 aa)
SHISA8Shisa family member 8. (386 aa)
RFX2DNA-binding protein RFX2; Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function. Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters. Probably activates transcription of the testis-specific histone gene HIST1H1T. (742 aa)
PHYHIPLPhytanoyl-CoA hydroxylase interacting protein-like; May play a role in the development of the central system. Belongs to the PHYHIP family. (631 aa)
PIFOProtein pitchfork. (192 aa)
CHI3L2Chitinase 3 like 2; Belongs to the glycosyl hydrolase 18 family. (402 aa)
CEP78Centrosomal protein 78. (806 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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