STRINGSTRING
SEMA3F SEMA3F SEMA3A SEMA3A LAMC2 LAMC2 RAC3 RAC3 CHN1 CHN1 NTN1 NTN1 NTN3 NTN3 NOG NOG EGR2 EGR2 NTN5 NTN5 SLIT2 SLIT2 SLIT1 SLIT1 LHX3 LHX3 LHX1 LHX1 PLXNA3 PLXNA3 ERBB2 ERBB2 MYCBP2 MYCBP2 KIF5C KIF5C PLXNA4 PLXNA4 RHOH RHOH RAC2 RAC2 EPHA4 EPHA4 HOXA2 HOXA2 CDK5 CDK5 LHX4 LHX4 RNF165 RNF165 RHOG RHOG ALCAM ALCAM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (792 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
LAMC2Laminin subunit gamma 2. (1191 aa)
RAC3Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...] (192 aa)
CHN1N-chimaerin; GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance (By similarity). (459 aa)
NTN1Netrin 1. (603 aa)
NTN3Netrin 3. (567 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
EGR2Early growth response 2. (485 aa)
NTN5Netrin 5. (489 aa)
SLIT2Slit guidance ligand 2. (1534 aa)
SLIT1Slit guidance ligand 1. (1534 aa)
LHX3LIM homeodomain 3 protein b isoform. (403 aa)
LHX1LIM homeobox 1. (406 aa)
PLXNA3Plexin A3. (1897 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
MYCBP2MYC binding protein 2. (4553 aa)
KIF5CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (957 aa)
PLXNA4Plexin A4. (1428 aa)
RHOHRho-related GTP-binding protein RhoH; Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils. Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphor [...] (191 aa)
RAC2Ras-related C3 botulinum toxin substrate 2; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase (By similarity). (192 aa)
EPHA4EPH receptor A4. (986 aa)
HOXA2Homeobox protein Hox-A2; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Proboscipedia subfamily. (372 aa)
CDK5Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neu [...] (292 aa)
LHX4LIM homeobox 4. (390 aa)
RNF165Ring finger protein 165. (347 aa)
RHOGRas homolog gene family, member G (Rho G). (191 aa)
ALCAMCD166 antigen; Cell adhesion molecule that mediates both heterotypic cell- cell contacts via its interaction with CD6, as well as homotypic cell- cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube f [...] (583 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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