node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCD4 | MMACHC | ENSBTAP00000019482 | ENSBTAP00000022638 | ATP binding cassette subfamily D member 4. | Methylmalonic aciduria and homocystinuria type C protein homolog; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione- dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalami [...] | 0.684 |
ABCD4 | MTR | ENSBTAP00000019482 | ENSBTAP00000067894 | ATP binding cassette subfamily D member 4. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.486 |
ABCD4 | TCN2 | ENSBTAP00000019482 | ENSBTAP00000029446 | ATP binding cassette subfamily D member 4. | Transcobalamin-2; Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells; Belongs to the eukaryotic cobalamin transport proteins family. | 0.514 |
AMN | CBLIF | ENSBTAP00000020912 | ENSBTAP00000015993 | Amnion associated transmembrane protein. | Cobalamin binding intrinsic factor. | 0.673 |
AMN | CUBN | ENSBTAP00000020912 | ENSBTAP00000039211 | Amnion associated transmembrane protein. | Cubilin. | 0.994 |
CBLIF | AMN | ENSBTAP00000015993 | ENSBTAP00000020912 | Cobalamin binding intrinsic factor. | Amnion associated transmembrane protein. | 0.673 |
CBLIF | CUBN | ENSBTAP00000015993 | ENSBTAP00000039211 | Cobalamin binding intrinsic factor. | Cubilin. | 0.988 |
CUBN | AMN | ENSBTAP00000039211 | ENSBTAP00000020912 | Cubilin. | Amnion associated transmembrane protein. | 0.994 |
CUBN | CBLIF | ENSBTAP00000039211 | ENSBTAP00000015993 | Cubilin. | Cobalamin binding intrinsic factor. | 0.988 |
CUBN | MMACHC | ENSBTAP00000039211 | ENSBTAP00000022638 | Cubilin. | Methylmalonic aciduria and homocystinuria type C protein homolog; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione- dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalami [...] | 0.504 |
CUBN | MTR | ENSBTAP00000039211 | ENSBTAP00000067894 | Cubilin. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.495 |
CUBN | TCN2 | ENSBTAP00000039211 | ENSBTAP00000029446 | Cubilin. | Transcobalamin-2; Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells; Belongs to the eukaryotic cobalamin transport proteins family. | 0.760 |
MMAA | MMACHC | ENSBTAP00000029802 | ENSBTAP00000022638 | Metabolism of cobalamin associated A. | Methylmalonic aciduria and homocystinuria type C protein homolog; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione- dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalami [...] | 0.444 |
MMAA | MMADHC | ENSBTAP00000029802 | ENSBTAP00000064159 | Metabolism of cobalamin associated A. | Metabolism of cobalamin associated D. | 0.453 |
MMAA | MTR | ENSBTAP00000029802 | ENSBTAP00000067894 | Metabolism of cobalamin associated A. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.404 |
MMAB | MMACHC | ENSBTAP00000006821 | ENSBTAP00000022638 | Corrinoid adenosyltransferase; Adenosyltransferase involved in intracellular vitamin B12 metabolism. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer taht is stimulated by ATP-binding to MMAB and gated by MMAA. | Methylmalonic aciduria and homocystinuria type C protein homolog; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione- dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalami [...] | 0.704 |
MMAB | MMADHC | ENSBTAP00000006821 | ENSBTAP00000064159 | Corrinoid adenosyltransferase; Adenosyltransferase involved in intracellular vitamin B12 metabolism. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer taht is stimulated by ATP-binding to MMAB and gated by MMAA. | Metabolism of cobalamin associated D. | 0.842 |
MMAB | MTR | ENSBTAP00000006821 | ENSBTAP00000067894 | Corrinoid adenosyltransferase; Adenosyltransferase involved in intracellular vitamin B12 metabolism. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer taht is stimulated by ATP-binding to MMAB and gated by MMAA. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.604 |
MMACHC | ABCD4 | ENSBTAP00000022638 | ENSBTAP00000019482 | Methylmalonic aciduria and homocystinuria type C protein homolog; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione- dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalami [...] | ATP binding cassette subfamily D member 4. | 0.684 |
MMACHC | CUBN | ENSBTAP00000022638 | ENSBTAP00000039211 | Methylmalonic aciduria and homocystinuria type C protein homolog; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione- dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalami [...] | Cubilin. | 0.504 |