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| | PTPRJ | Peptidylprolyl isomerase. (1344 aa) |
| | TESK1 | Testis associated actin remodelling kinase 1. (632 aa) |
| | CARMIL1 | Capping protein regulator and myosin 1 linker 1. (1422 aa) |
| | EFNA5 | Ephrin-A5; Belongs to the ephrin family. (228 aa) |
| | EFEMP2 | EGF containing fibulin extracellular matrix protein 2. (450 aa) |
| | ACTN4 | Alpha-actinin-4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcri [...] (1032 aa) |
| | EPHA1 | EPH receptor A1. (1014 aa) |
| | FBLN1 | Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (706 aa) |
| | DLC1 | Rho GTPase-activating protein 7; Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality (By similarity). (1523 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | S100A10 | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. (97 aa) |
| | CALR | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. (417 aa) |
| | SEMA3E | Semaphorin 3E; Belongs to the semaphorin family. (775 aa) |
| | CASS4 | Cas scaffold protein family member 4. (811 aa) |
| | FERMT2 | Fermitin family member 2. (680 aa) |
| | ACVRL1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa) |
| | CORO2B | Coronin; Belongs to the WD repeat coronin family. (480 aa) |
| | ABI3BP | Fibronectin type-III domain-containing protein. (386 aa) |
| | UNC13D | Unc-13 homolog D. (1145 aa) |
| | NPNT | Nephronectin. (616 aa) |
| | PEAK1 | Pseudopodium enriched atypical kinase 1. (1747 aa) |
| | ENSBTAP00000073174 | Uncharacterized protein. (1340 aa) |
| | PLAU | Urokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin; Belongs to the peptidase S1 family. (440 aa) |
| | CDH13 | Cadherin-13; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth (By similarity). (701 aa) |
| | THBS1 | Thrombospondin-1; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions. Ligand for CD36 mediating antiangiogenic properties (By similarity). May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity); Belongs to the thrombospondin family. (1175 aa) |
| | FBLN2 | Fibulin 2. (1207 aa) |
| | COL8A1 | Collagen type VIII alpha 1 chain. (745 aa) |
| | NOTCH1 | Notch receptor 1. (2533 aa) |
| | COL1A1 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1463 aa) |
| | ITGB1BP1 | Integrin beta-1-binding protein 1; Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling [...] (200 aa) |
| | ALOX15 | Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12- HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the o [...] (663 aa) |
| | ECM2 | Extracellular matrix protein 2; Promotes matrix assembly and cell adhesiveness. (702 aa) |
| | PLG | Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] (812 aa) |
| | C15H11orf34 | Placenta-expressed transcript 1 protein; Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity). (275 aa) |
| | VTN | Vitronectin. (476 aa) |
| | RELL2 | RELT-like protein 2; Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed. (303 aa) |
| | ACTG1 | Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (375 aa) |
| | EPHA3 | EPH receptor A3. (984 aa) |
| | JUP | Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] (745 aa) |
| | EGFL6 | EGF like domain multiple 6. (515 aa) |
| | BCL2 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). (229 aa) |
| | EGFLAM | Pikachurin; Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness (By similarity). (1059 aa) |
| | THY1 | Thy-1 cell surface antigen. (161 aa) |
| | NRP1 | Neuropilin; Belongs to the neuropilin family. (923 aa) |
| | TEK | Angiopoietin-1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angi [...] (1125 aa) |
| | MYOC | Myocilin, C-terminal fragment; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. [...] (490 aa) |
| | DAPK3 | Death associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa) |
| | PRKCE | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (684 aa) |
| | RRAS | Related RAS viral (R-ras) oncogene homolog. (218 aa) |
| | FLNA | Filamin A. (2647 aa) |
| | OLFM4 | Olfactomedin 4. (540 aa) |
| | SPOCK2 | SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2. (424 aa) |
| | FUT1 | L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (416 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | EMP2 | Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation. Facilitates surface trafficking and the formation of lipid rafts bearing GPI-anchor proteins. Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T- cell mediated cytotoxicity. R [...] (167 aa) |
| | NID1 | NID1 protein. (1241 aa) |
| | MACF1 | Microtubule actin crosslinking factor 1. (7311 aa) |
| | CCL21 | C-C motif chemokine ligand 21. (133 aa) |
| | AGR2 | Anterior gradient 2, protein disulphide isomerase family member. (175 aa) |
| | MYF5 | Myogenic factor 5; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (255 aa) |
| | SFRP1 | Secreted frizzled-related protein 1; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metane [...] (308 aa) |
| | MYADM | Myeloid-associated differentiation marker. (322 aa) |
| | PREX1 | Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1653 aa) |
| | COL26A1 | Collagen type XXVI alpha 1 chain. (438 aa) |
| | DDR1 | Tyrosine-protein kinase receptor. (915 aa) |
| | APOD | Apolipoprotein D; APOD occurs in the macromolecular complex with lecithin- transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts (By similarity). (212 aa) |
| | MELTF | Melanotransferrin; Belongs to the transferrin family. (739 aa) |
| | GSK3B | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (492 aa) |
| | EPB41L5 | Band 4.1-like protein 5; May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells. (722 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa) |
| | VCL | Vinculin. (1134 aa) |
| | VWC2 | Von Willebrand factor C domain containing 2. (326 aa) |
| | ROCK1 | Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1356 aa) |
| | DMTN | Dematin; Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator [...] (467 aa) |
| | COL16A1 | Collagen type XVI alpha 1 chain. (1257 aa) |
| | FMN1 | Formin 1. (1320 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (302 aa) |
| | NEDD9 | Neural precursor cell expressed, developmentally down-regulated 9. (830 aa) |
| | VEGFA | Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (214 aa) |
| | ONECUT1 | One cut domain family member. (465 aa) |
| | PDGFB | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa) |
| | ADAM15 | ADAM metallopeptidase domain 15. (866 aa) |
| | CSF1 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (575 aa) |
| | LIMS2 | LIM and senescent cell antigen-like-containing domain protein 2; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (350 aa) |
| | MINK1 | Misshapen like kinase 1. (1367 aa) |
| | ABL1 | Tyrosine-protein kinase. (1151 aa) |
| | VIT | Vitrin; Promotes matrix assembly and cell adhesiveness. Plays a role in spinal cord formation by regulating the proliferation and differentiation of neural stem cells. (652 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa) |
| | CDC42 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (191 aa) |
| | CCN1 | Cellular communication network factor 1. (463 aa) |
| | GPM6B | Glycoprotein M6B. (328 aa) |
| | CCL28 | C-C motif chemokine. (129 aa) |
| | PDPN | Podoplanin. (169 aa) |
| | ARL2 | ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the ef [...] (184 aa) |
| | APOA1 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. (265 aa) |
| | FZD7 | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa) |
| | ARHGAP6 | Rho GTPase activating protein 6. (705 aa) |
| | STK4 | Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] (487 aa) |
| | AP1AR | Adaptor related protein complex 1 associated regulatory protein. (302 aa) |
| | RHOA | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (193 aa) |
| | WDPCP | WD repeat containing planar cell polarity effector. (645 aa) |
| | TSC1 | TSC complex subunit 1. (1159 aa) |
| | CCL25 | C-C motif chemokine ligand 25. (149 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (304 aa) |
| | P4HB | Protein disulfide-isomerase; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chape [...] (565 aa) |
| | BST1 | Bone marrow stromal cell antigen 1. (318 aa) |
| | JAG1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa) |
| | CORO1C | Coronin; Belongs to the WD repeat coronin family. (474 aa) |
| | SPRY4 | Protein sprouty homolog 4; Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras (By similarity). Inhibits Ras-independent, but not Ras- dependent, activation of RAF1 (By similarity); Belongs to the sprouty family. (299 aa) |
| | FN1 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2601 aa) |
| | RCC2 | Regulator of chromosome condensation 2. (520 aa) |
| | RASA1 | Ras GTPase-activating protein 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21. (1044 aa) |
| | UTRN | Utrophin. (3432 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (784 aa) |
| | C1QBP | Complement component 1 Q subcomponent-binding protein, mitochondrial; Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a [...] (278 aa) |
| | ACER2 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa) |
| | LIMS1 | LIM zinc finger domain containing 1. (449 aa) |
| | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] (724 aa) |
| | ANGPT2 | Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). (496 aa) |
| | RAC2 | Ras-related C3 botulinum toxin substrate 2; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase (By similarity). (192 aa) |
| | EMILIN1 | Elastin microfibril interfacer 1. (1015 aa) |
| | CAMSAP3 | Calmodulin regulated spectrin associated protein family member 3. (1276 aa) |
| | FOXF1 | Forkhead box F1. (437 aa) |
| | HSD17B12 | Very-long-chain 3-oxoacyl-CoA reductase; Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3- hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membra [...] (312 aa) |
| | HRG | Histidine-rich glycoprotein. (536 aa) |
| | SLK | STE20 like kinase. (1240 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa) |
| | ILK | Integrin-linked protein kinase; Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. (452 aa) |
| | SKAP1 | Src kinase associated phosphoprotein 1. (370 aa) |
| | NEXMIF | Neurite extension and migration factor. (1484 aa) |
| | EDIL3 | EGF like repeats and discoidin domains 3. (480 aa) |
| | KANK1 | KN motif and ankyrin repeat domains 1. (1384 aa) |
| | PTPRA | Receptor-type tyrosine-protein phosphatase alpha. (813 aa) |
| | BCL6 | BCL6 transcription repressor. (706 aa) |
| | PHLDB2 | Pleckstrin homology like domain family B member 2. (1343 aa) |
| | AJAP1 | Adherens junctions associated protein 1. (416 aa) |
| | GREM1 | CTCK domain-containing protein. (240 aa) |
| | CASK | Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (935 aa) |
| | LDB1 | LIM domain binding 1. (392 aa) |
| | GCNT2 | Glucosaminyl (N-acetyl) transferase 2 (I blood group). (402 aa) |
| | MMP12 | ZnMc domain-containing protein. (470 aa) |
| | HOXA7 | Homeobox A7. (238 aa) |
| | LIMCH1 | LIM and calponin homology domains 1. (1542 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (766 aa) |
| | RAC1 | Ras-related C3 botulinum toxin substrate 1. (276 aa) |
| | ONECUT2 | One cut domain family member. (557 aa) |
| | TBCD | Tubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP- bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes ep [...] (1422 aa) |
| | TRIOBP | TRIO and F-actin binding protein. (580 aa) |
| | SPOCK1 | Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (Testican) 1. (442 aa) |
| | CIB1 | Calcium and integrin-binding protein 1; Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin- mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulat [...] (201 aa) |
| | FERMT1 | Fermitin family member 1. (679 aa) |
| | RREB1 | Ras responsive element binding protein 1. (1745 aa) |
| | PPM1F | Protein phosphatase, Mg2+/Mn2+ dependent 1F. (557 aa) |
| | RAC3 | Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...] (192 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | CCDC80 | Coiled-coil domain containing 80. (971 aa) |
| | DOCK5 | Dedicator of cytokinesis 5; Belongs to the DOCK family. (1962 aa) |
| | RSU1 | Ras suppressor protein 1; Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro (By similarity). (278 aa) |
| | RIN2 | Ras and Rab interactor 2. (909 aa) |
