STRINGSTRING
CUL2 CUL2 FBXL6 FBXL6 CACYBP CACYBP CKS2 CKS2 FBXL21 FBXL21 FBXL15 FBXL15 TMEM183A TMEM183A FBXL7 FBXL7 FBXW4 FBXW4 FBXL4 FBXL4 ARIH1 ARIH1 FBXO33 FBXO33 FBXO2 FBXO2 FBXO44 FBXO44 BTRC BTRC FBXO42 FBXO42 FBXL22 FBXL22 SPSB4 SPSB4 DMAC2 DMAC2 FBXO15 FBXO15 CMIP CMIP SKP2 SKP2 TRIM21 TRIM21 AMN1 AMN1 FBXO9 FBXO9 F1MKA7_BOVIN F1MKA7_BOVIN FBXO32 FBXO32 SPSB3 SPSB3 FBXO4 FBXO4 FBXO39 FBXO39 FBXL3 FBXL3 FBXO7 FBXO7 F1MHW5_BOVIN F1MHW5_BOVIN FBXL5 FBXL5 DAW1 DAW1 FBXL8 FBXL8 CKS1B CKS1B CCNF CCNF FBXL12 FBXL12 SKP1 SKP1 LOC525426 LOC525426 FBXL18 FBXL18 FBXO45 FBXO45 FBXW8 FBXW8 FBXL16 FBXL16 G3N0Q3_BOVIN G3N0Q3_BOVIN FBXO48 FBXO48 LOC101903496 LOC101903496 NCCRP1 NCCRP1 FBXL14 FBXL14 FBXL17 FBXL17 FBXO31 FBXO31 FBXL2 FBXL2 CUL5 CUL5 FBH1 FBH1 LOC508086 LOC508086 CUL1 CUL1 FBXL20 FBXL20 FBXW7 FBXW7 ENSBTAP00000065568 ENSBTAP00000065568 FBXW11 FBXW11 LOC789309 LOC789309 FBXO25 FBXO25 FBXL13 FBXL13 SPSB1 SPSB1 FBXO6 FBXO6 FBXO17 FBXO17 ENSBTAP00000070247 ENSBTAP00000070247 SPSB2 SPSB2 FBXO25-2 FBXO25-2 TRAF7 TRAF7 ENSBTAP00000072606 ENSBTAP00000072606 FBXW5 FBXW5 USP47 USP47
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CUL2CUL2 protein; Belongs to the cullin family. (745 aa)
FBXL6F-box and leucine rich repeat protein 6. (534 aa)
CACYBPCalcyclin-binding protein; May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity). (230 aa)
CKS2Cyclin-dependent kinases regulatory subunit 2; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function; Belongs to the CKS family. (79 aa)
FBXL21F-box/LRR-repeat protein 21; Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock r [...] (434 aa)
FBXL15F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity); Belongs to the FBXL15 family. (335 aa)
TMEM183ATransmembrane protein 183. (376 aa)
FBXL7F-box and leucine rich repeat protein 7. (444 aa)
FBXW4F-box and WD repeat domain containing 4. (640 aa)
FBXL4F-box/LRR-repeat protein 4. (621 aa)
ARIH1E3 ubiquitin-protein ligase ARIH1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin- [...] (555 aa)
FBXO33F-box protein 33. (560 aa)
FBXO2F-box only protein 2; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotransl [...] (297 aa)
FBXO44FBXO44 protein. (255 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (569 aa)
FBXO42F-box protein 42. (717 aa)
FBXL22F-box and leucine-rich protein 22; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC) (By similarity). (284 aa)
SPSB4SplA/ryanodine receptor domain and SOCS box containing 4. (273 aa)
DMAC2Distal membrane-arm assembly complex protein 2; Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I. (301 aa)
FBXO15F-box only protein 15; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. (514 aa)
CMIPC-Maf inducing protein. (772 aa)
SKP2SKP2 protein. (424 aa)
TRIM21E3 ubiquitin-protein ligase TRIM21; E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degrad [...] (469 aa)
AMN1Protein AMN1 homolog; Belongs to the AMN1 family. (258 aa)
FBXO9F-box only protein 9; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTOR [...] (437 aa)
F1MKA7_BOVINUncharacterized protein. (280 aa)
FBXO32F-box only protein 32; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity). (355 aa)
SPSB3SPRY domain-containing SOCS box protein 3; May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the SPSB family. (345 aa)
FBXO4F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). (387 aa)
FBXO39F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. (443 aa)
FBXL3F-box and leucine rich repeat protein 3. (321 aa)
FBXO7F-box only protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination (By similarity). (522 aa)
F1MHW5_BOVINUncharacterized protein. (309 aa)
FBXL5F-box/LRR-repeat protein 5; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued (By similarity). (691 aa)
DAW1Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly. Belongs to the WD repeat WDR69 family. (415 aa)
FBXL8F-box/LRR-repeat protein 8; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. (542 aa)
CKS1BCyclin-dependent kinases regulatory subunit 1; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function; Belongs to the CKS family. (79 aa)
CCNFCyclin-F; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. Belongs to the cyclin family. Cyclin AB subfamily. (1215 aa)
FBXL12F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia (By similarity). (326 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa)
LOC525426F-box domain-containing protein. (621 aa)
FBXL18F-box and leucine rich repeat protein 18. (711 aa)
FBXO45F-box protein 45. (281 aa)
FBXW8F-box and WD repeat domain containing 8. (599 aa)
FBXL16F-box and leucine rich repeat protein 16. (482 aa)
G3N0Q3_BOVINCULLIN_2 domain-containing protein; Belongs to the cullin family. (767 aa)
FBXO48F-box protein 48. (155 aa)
LOC101903496Uncharacterized protein. (254 aa)
NCCRP1Non-specific cytotoxic cell receptor protein 1 homolog (zebrafish). (260 aa)
FBXL14F-box/LRR-repeat protein 14; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1 (By similarity). (474 aa)
FBXL17F-box and leucine rich repeat protein 17. (675 aa)
FBXO31F-box protein 31. (529 aa)
FBXL2F-box/LRR-repeat protein 2; Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degrad [...] (433 aa)
CUL5Cullin 5; Belongs to the cullin family. (811 aa)
FBH1F-box DNA helicase 1. (1067 aa)
LOC508086Uncharacterized protein. (309 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
FBXL20F-box/LRR-repeat protein 20; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). (442 aa)
FBXW7F-box/WD repeat-containing protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (By similarity). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. Acts as a negative regulator of JNK si [...] (706 aa)
ENSBTAP00000065568Uncharacterized protein. (216 aa)
FBXW11F-box and WD repeat domain containing 11. (563 aa)
LOC789309Uncharacterized protein. (279 aa)
FBXO25F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). (391 aa)
FBXL13F-box and leucine rich repeat protein 13. (732 aa)
SPSB1SPRY domain-containing SOCS box protein 1; Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity). Belongs to [...] (324 aa)
FBXO6F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] (329 aa)
FBXO17FBXO17 protein. (140 aa)
ENSBTAP00000070247Uncharacterized protein. (207 aa)
SPSB2SplA/ryanodine receptor domain and SOCS box containing 2. (267 aa)
FBXO25-2Uncharacterized protein. (220 aa)
TRAF7Ring finger and WD repeat domain 1 isoform 1. (669 aa)
ENSBTAP00000072606Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
FBXW5F-box and WD repeat domain containing 5. (670 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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