node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASCL1 | DBX1 | ENSBTAP00000021592 | ENSBTAP00000003543 | Achaete-scute family bHLH transcription factor 1. | Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity); Belongs to the H2.0 homeobox family. | 0.420 |
ASCL1 | FOXN4 | ENSBTAP00000021592 | ENSBTAP00000014397 | Achaete-scute family bHLH transcription factor 1. | Forkhead box N4. | 0.619 |
ASCL1 | LHX3 | ENSBTAP00000021592 | ENSBTAP00000051511 | Achaete-scute family bHLH transcription factor 1. | LIM homeodomain 3 protein b isoform. | 0.604 |
ASCL1 | NKX2-2 | ENSBTAP00000021592 | ENSBTAP00000013574 | Achaete-scute family bHLH transcription factor 1. | NK2 homeobox 2. | 0.510 |
ASCL1 | SHH | ENSBTAP00000021592 | ENSBTAP00000034059 | Achaete-scute family bHLH transcription factor 1. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.627 |
CHRD | SHH | ENSBTAP00000043209 | ENSBTAP00000034059 | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.554 |
DBX1 | ASCL1 | ENSBTAP00000003543 | ENSBTAP00000021592 | Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity); Belongs to the H2.0 homeobox family. | Achaete-scute family bHLH transcription factor 1. | 0.420 |
DBX1 | LHX3 | ENSBTAP00000003543 | ENSBTAP00000051511 | Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity); Belongs to the H2.0 homeobox family. | LIM homeodomain 3 protein b isoform. | 0.498 |
DBX1 | SHH | ENSBTAP00000003543 | ENSBTAP00000034059 | Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity); Belongs to the H2.0 homeobox family. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.591 |
DLL4 | FOXN4 | ENSBTAP00000013680 | ENSBTAP00000014397 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Forkhead box N4. | 0.596 |
DLL4 | SHH | ENSBTAP00000013680 | ENSBTAP00000034059 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.420 |
DMRT3 | GLI3 | ENSBTAP00000019971 | ENSBTAP00000033519 | Doublesex and mab-3 related transcription factor 3. | GLI family zinc finger 3. | 0.425 |
FOXN4 | ASCL1 | ENSBTAP00000014397 | ENSBTAP00000021592 | Forkhead box N4. | Achaete-scute family bHLH transcription factor 1. | 0.619 |
FOXN4 | DLL4 | ENSBTAP00000014397 | ENSBTAP00000013680 | Forkhead box N4. | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | 0.596 |
FOXN4 | LHX3 | ENSBTAP00000014397 | ENSBTAP00000051511 | Forkhead box N4. | LIM homeodomain 3 protein b isoform. | 0.611 |
GLI3 | DMRT3 | ENSBTAP00000033519 | ENSBTAP00000019971 | GLI family zinc finger 3. | Doublesex and mab-3 related transcription factor 3. | 0.425 |
GLI3 | INTU | ENSBTAP00000033519 | ENSBTAP00000017038 | GLI family zinc finger 3. | Protein inturned; Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity ef [...] | 0.570 |
GLI3 | SHH | ENSBTAP00000033519 | ENSBTAP00000034059 | GLI family zinc finger 3. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.899 |
GLI3 | SMO | ENSBTAP00000033519 | ENSBTAP00000017670 | GLI family zinc finger 3. | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.959 |
GLI3 | SUFU | ENSBTAP00000033519 | ENSBTAP00000069136 | GLI family zinc finger 3. | Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] | 0.997 |