STRINGSTRING
ISL1 ISL1 LHX4 LHX4 MNX1 MNX1 NKX2-2 NKX2-2 ABT1 ABT1 GBX1 GBX1 SCYL3 SCYL3 HOXD10 HOXD10 ISL2 ISL2 TBX20 TBX20 PHOX2A PHOX2A LBX1 LBX1 GLI3 GLI3 SHH SHH SCYL1 SCYL1 LHX3 LHX3 OLIG3 OLIG3 PTCH1 PTCH1 TCTN1 TCTN1 SOX4 SOX4 OLIG2 OLIG2 HOXC10 HOXC10 CLN8 CLN8 SUFU SUFU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ISL1ISL LIM homeobox 1. (349 aa)
LHX4LIM homeobox 4. (390 aa)
MNX1Motor neuron and pancreas homeobox 1. (409 aa)
NKX2-2NK2 homeobox 2. (273 aa)
ABT1Activator of basal transcription 1; Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity). (275 aa)
GBX1Gastrulation brain homeobox 1. (406 aa)
SCYL3SCY1 like pseudokinase 3. (734 aa)
HOXD10HOXD10 protein. (340 aa)
ISL2ISL LIM homeobox 2. (359 aa)
TBX20T-box transcription factor 20. (449 aa)
PHOX2APaired like homeobox 2A. (284 aa)
LBX1Ladybird homeobox 1. (282 aa)
GLI3GLI family zinc finger 3. (1587 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
SCYL1N-terminal kinase-like protein; Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro. (807 aa)
LHX3LIM homeodomain 3 protein b isoform. (403 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
PTCH1SSD domain-containing protein. (1453 aa)
TCTN1Tectonic family member 1. (588 aa)
SOX4Transcription factor SOX. (481 aa)
OLIG2Oligodendrocyte transcription factor 2. (327 aa)
HOXC10Homeobox C10. (373 aa)
CLN8TLC domain-containing protein. (278 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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