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| | CSF1R | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa) |
| | KIF14 | Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1621 aa) |
| | SYNE2 | Spectrin repeat containing nuclear envelope protein 2. (6919 aa) |
| | PLXNA3 | Plexin A3. (1897 aa) |
| | FUT1 | L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (416 aa) |
| | BBS2 | Bardet-Biedl syndrome 2 protein homolog. (721 aa) |
| | GLI3 | GLI family zinc finger 3. (1587 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa) |
| | POU3F2 | POU domain protein. (438 aa) |
| | TRAPPC9 | Trafficking protein particle complex subunit 9; Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the NIBP family. (1138 aa) |
| | DIXDC1 | DIX domain containing 1. (472 aa) |
| | TTC8 | Tetratricopeptide repeat domain 8. (501 aa) |
| | PSEN1 | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (478 aa) |
| | CEP120 | Centrosomal protein of 120 kDa; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. May play a role in centriole duplication during mitosis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK [...] (987 aa) |
| | DLX2 | Distal-less homeobox 2. (331 aa) |
| | MDGA1 | MAM domain containing glycosylphosphatidylinositol anchor 1. (955 aa) |
| | LHX1 | LIM homeobox 1. (406 aa) |
| | FGF13-2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa) |
| | MGARP | Protein MGARP; Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity). (357 aa) |
| | ATP1A2 | Sodium/potassium-transporting ATPase subunit alpha-2; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients (By similarity). Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. (1020 aa) |
| | MKKS | Uncharacterized protein. (570 aa) |
| | FBXO45 | F-box protein 45. (281 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (346 aa) |
| | GSK3B | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (492 aa) |
| | CDK5R2 | Cyclin-dependent kinase 5 activator. (373 aa) |
| | CDK5R1 | Cyclin-dependent kinase 5 activator 1, p25; p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution (By sim [...] (307 aa) |
| | NUMB | NUMB endocytic adaptor protein. (653 aa) |
| | TACC3 | Transforming acidic coiled-coil containing protein 3. (810 aa) |
| | DNAH5 | Dynein axonemal heavy chain 5. (4610 aa) |
| | LRRK2 | Leucine rich repeat kinase 2. (2527 aa) |
| | KAT2A | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa) |
| | SLIT1 | Slit guidance ligand 1. (1534 aa) |
| | SLIT2 | Slit guidance ligand 2. (1534 aa) |
| | ROBO1 | Roundabout guidance receptor 1. (1492 aa) |
| | NTRK2 | Tyrosine-protein kinase receptor. (837 aa) |
| | SUN1 | Sad1 and UNC84 domain containing 1. (885 aa) |
| | RTN4R | Reticulon 4 receptor. (473 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (302 aa) |
| | SLC7A11 | Solute carrier family 7 member 11. (488 aa) |
| | ADGRG1 | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (746 aa) |
| | TCTN1 | Tectonic family member 1. (588 aa) |
| | GSX2 | GS homeobox 2. (305 aa) |
| | INHBA | Inhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (425 aa) |
| | POU3F3 | POU domain protein. (499 aa) |
| | PROX1 | Prospero homeobox 1. (737 aa) |
| | SRGAP2 | Uncharacterized protein. (1071 aa) |
| | BMERB1 | BMERB domain containing 1. (204 aa) |
| | PHACTR1 | Phosphatase and actin regulator. (609 aa) |
| | DAB2IP | DAB2 interacting protein. (1169 aa) |
| | LRP8 | LDL receptor related protein 8. (1014 aa) |
| | ATF5 | Activating transcription factor 5. (281 aa) |
| | DCX | Doublecortin. (360 aa) |
| | LAMB1 | Laminin subunit beta 1. (1983 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (414 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (657 aa) |
| | PTPRS | Protein tyrosine phosphatase receptor type S. (1998 aa) |
| | NPY | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. (97 aa) |
| | TACC1 | Transforming acidic coiled-coil containing protein 1. (746 aa) |
| | MPP5 | Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa) |
| | RPGRIP1L | RPGRIP1 like. (1270 aa) |
| | RYK | Receptor like tyrosine kinase. (601 aa) |
| | NDEL1 | NudE neurodevelopment protein 1 like 1. (377 aa) |
| | TACC2 | Transforming acidic coiled-coil containing protein 2. (2625 aa) |
| | PAX6 | Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity); Belongs to the paired homeobox family. (436 aa) |
| | KIRREL3 | Kirre like nephrin family adhesion molecule 3. (745 aa) |
| | MCPH1 | Microcephalin 1. (860 aa) |
| | AGTPBP1 | ATP/GTP binding protein 1. (1181 aa) |
| | BCAN | Brevican core protein; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. (912 aa) |
| | CCDC141 | Coiled-coil domain containing 141. (1528 aa) |
| | CDON | Cell adhesion associated, oncogene regulated. (1247 aa) |
| | BTBD3 | BTB domain containing 3. (526 aa) |
| | ARX | Aristaless related homeobox. (560 aa) |
| | ENSBTAP00000067624 | Uncharacterized protein. (83 aa) |
| | PAFAH1B1 | Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa) |
| | FOXG1 | Forkhead box G1. (490 aa) |
| | NKX2-1 | NK2 homeobox 1. (408 aa) |
| | ENSBTAP00000069441 | annotation not available (83 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] (513 aa) |
| | PEX5 | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. (640 aa) |
| | SCT | Secretin; Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis. Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells. Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content. Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the p [...] (157 aa) |
| | CELF1 | CUGBP Elav-like family member 1. (513 aa) |
| | ALK | Tyrosine-protein kinase receptor. (1451 aa) |
| | ERBB4 | Receptor protein-tyrosine kinase. (1262 aa) |
| | SEMA3A | Semaphorin 3A; Belongs to the semaphorin family. (772 aa) |
| | PAX5 | Paired box 5. (392 aa) |
| | OGDH | 2-oxoglutarate dehydrogenase, mitochondrial; 2-oxoglutarate dehydrogenase (E1) component of the 2- oxoglutarate dehydrogenase complex, which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl- Co [...] (1038 aa) |
| | NIN | Ninein. (2167 aa) |
| | YWHAE | 14-3-3 protein epsilon; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (By similarity). (263 aa) |
| | LMX1A | LIM homeobox transcription factor 1 alpha. (382 aa) |
| | SLC1A2 | Amino acid transporter. (595 aa) |
| | RFX4 | Regulatory factor X4. (641 aa) |
| | NEUROD6 | Neurogenic differentiation factor 6; Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene (By similarity). (337 aa) |
| | HES1 | Transcription factor HES-1; Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'- CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). (280 aa) |
| | AQP1 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (271 aa) |
| | FGF8 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa) |
| | TSKU | Tsukushi, small leucine rich proteoglycan. (344 aa) |
| | TRA2B | Transformer-2 protein homolog beta; Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA (By similarity); Belongs to the splicing factor SR family. (288 aa) |
| | NEUROD1 | Neurogenic differentiation factor. (356 aa) |
| | EMX1 | Empty spiracles homeobox 1. (288 aa) |
| | SECISBP2 | SECIS binding protein 2. (844 aa) |
| | KDM2B | Lysine demethylase 2B. (1424 aa) |
| | HES5 | Hes family bHLH transcription factor 5. (227 aa) |
| | ATOH1 | Atonal bHLH transcription factor 1. (352 aa) |
| | EMX2 | Homeobox protein EMX2; Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system (By similarity). (253 aa) |
| | LHX5 | LIM homeobox 5. (402 aa) |
| | DPCD | Protein DPCD; May play a role in the formation or function of ciliated cells. (203 aa) |
| | RELN | Reelin; Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity); Belongs to the reel [...] (3460 aa) |
| | SUN2 | Sad1 and UNC84 domain containing 2. (728 aa) |
| | AKIRIN2 | Akirin-2; Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity). (203 aa) |
| | BMP4 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa) |
| | RHOA | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (193 aa) |
| | FEZF1 | FEZ family zinc finger 1. (476 aa) |
| | BMP2 | Bone morphogenetic protein 2. (395 aa) |
| | ARL13B | ADP ribosylation factor like GTPase 13B. (429 aa) |
| | TSC1 | TSC complex subunit 1. (1159 aa) |
| | PEX13 | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins (By similarity). (403 aa) |
| | EPHB3 | EPH receptor B3. (997 aa) |
| | FUT10 | Alpha-(1,3)-fucosyltransferase 10; Probable fucosyltransferase. (467 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (304 aa) |
| | EXT1 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). (746 aa) |
| | UBA6 | Ubiquitin like modifier activating enzyme 6. (1057 aa) |
| | ATAT1 | Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (465 aa) |
| | BBS4 | Bardet-Biedl syndrome 4 protein homolog; May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the [...] (519 aa) |
| | CDK5 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neu [...] (292 aa) |
| | ASPM | Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3461 aa) |
| | HSD3B1 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. (382 aa) |
| | NFIB | Nuclear factor 1 B-type; Transcriptional activator of GFAP, essential for proper brain development. Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Belongs to the CTF/NF-I family. (561 aa) |
| | SALL1 | Spalt like transcription factor 1. (1316 aa) |
| | ALDH1A3 | Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa) |
| | NRG3 | Neuregulin 3. (701 aa) |
| | FAT4 | FAT atypical cadherin 4. (4982 aa) |
| | SLITRK5 | SLIT and NTRK like family member 5. (962 aa) |
| | DMRTA2 | Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development; Belongs to the DMRT family. (535 aa) |
| | DRD2 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (443 aa) |
| | LHX2 | LIM homeobox 2. (406 aa) |
| | RTN4 | Reticulon. (1230 aa) |
| | SEMA7A | Semaphorin 7A; Belongs to the semaphorin family. (664 aa) |
| | RARB | Retinoic acid receptor beta. (448 aa) |
| | TNR | Tenascin R. (1358 aa) |
| | IGF2BP1 | Insulin like growth factor 2 mRNA binding protein 1. (577 aa) |
| | RTN4RL1 | Reticulon 4 receptor like 1. (446 aa) |
| | ZDHHC16 | Palmitoyltransferase ZDHHC16; Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (By similarity). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (By similarity). May play a role in DNA damage response (By similarity). May be involved in apoptosis regu [...] (377 aa) |
| | SRF | Serum response factor. (509 aa) |
| | MFSD2A | Major facilitator superfamily domain containing 2A. (454 aa) |
| | NF2 | Neurofibromin 2. (596 aa) |
| | SMO | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa) |
| | UCHL5 | Ubiquitin carboxyl-terminal hydrolase isozyme L5; Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity). (328 aa) |
| | ATP1B2 | Sodium/potassium-transporting ATPase subunit beta-2; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known. (290 aa) |
| | NR2E1 | Nuclear receptor subfamily 2 group E member 1. (385 aa) |
| | DRAXIN | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (337 aa) |
| | PLXNA4 | Plexin A4. (1428 aa) |
| | CNTN2 | Contactin 2. (1040 aa) |
| | DLX1 | Distal-less homeobox 1. (255 aa) |
| | BTG2 | BTG anti-proliferation factor 2. (150 aa) |
| | MBOAT7 | Lysophospholipid acyltransferase 7; Acyltransferase which contributes to the regulation of free arachidonic acid (AA) in the cell through the remodeling of phospholipids. Mediates the conversion of lysophosphatidylinositol (1- acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2- diacyl-sn-glycero-3-phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor (By similarity). Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (By similarity). Required for [...] (472 aa) |
| | NDE1 | NudE neurodevelopment protein 1. (346 aa) |
| | ASCL1 | Achaete-scute family bHLH transcription factor 1. (219 aa) |
| | CTNNB1 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] (781 aa) |
| | KCNA1 | Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa) |
| | EFHC1 | EF-hand domain containing 1. (640 aa) |
| | BCL11B | BAF chromatin remodeling complex subunit BCL11B. (904 aa) |
| | TMEM108 | Transmembrane protein 108; Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrit [...] (587 aa) |
| | DLX5 | Distal-less homeobox 5. (289 aa) |
| | FOXB1 | Forkhead box B1. (325 aa) |
| | NARS1 | Asparagine--tRNA ligase, cytoplasmic; Belongs to the class-II aminoacyl-tRNA synthetase family. (559 aa) |
| | ZMIZ1 | Zinc finger MIZ-type containing 1. (1072 aa) |
| | NUMBL | NUMB like endocytic adaptor protein. (593 aa) |
| | CHD7 | Chromodomain helicase DNA binding protein 7. (2786 aa) |
| | EPHB2 | EPH receptor B2. (965 aa) |
| | BBS1 | BBS1 domain-containing protein. (667 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | FEZF2 | Fez family zinc finger protein 2; Transcription repressor. Binds to 5'GCAG-3' core sequence. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons (By similarity). May be responsible for mastitis resistance and innate immunity. (459 aa) |
| | HIF1A | Hypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequenc [...] (823 aa) |
| | ZIC3 | Uncharacterized protein. (465 aa) |
| | COL3A1 | Collagen alpha-1(III) chain. (1466 aa) |
| | TBR1 | T-box brain transcription factor 1. (682 aa) |
