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| | NDEL1 | NudE neurodevelopment protein 1 like 1. (377 aa) |
| | MPP5 | Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa) |
| | NPY | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. (97 aa) |
| | OLIG2 | Oligodendrocyte transcription factor 2. (327 aa) |
| | TAL1 | TAL bHLH transcription factor 1, erythroid differentiation factor. (328 aa) |
| | DCX | Doublecortin. (360 aa) |
| | BMPR1B | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | SOX4 | Transcription factor SOX. (481 aa) |
| | CEND1 | Cell cycle exit and neuronal differentiation 1. (146 aa) |
| | ISL1 | ISL LIM homeobox 1. (349 aa) |
| | C1H21orf91 | Chromosome 21 open reading frame 91 ortholog. (297 aa) |
| | TSKU | Tsukushi, small leucine rich proteoglycan. (344 aa) |
| | WNT7A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | EMX1 | Empty spiracles homeobox 1. (288 aa) |
| | SECISBP2 | SECIS binding protein 2. (844 aa) |
| | NKX6-1 | NK6 homeobox 1. (366 aa) |
| | DBX1 | Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity); Belongs to the H2.0 homeobox family. (345 aa) |
| | LHX5 | LIM homeobox 5. (402 aa) |
| | NR4A2 | Nuclear receptor subfamily 4 group A member 2; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity); Belongs to the nuclear hormone receptor family. NR4 subfamily. (598 aa) |
| | SCN1B | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. (218 aa) |
| | LHX4 | LIM homeobox 4. (390 aa) |
| | TTC21B | Tetratricopeptide repeat domain 21B. (1316 aa) |
| | MNX1 | Motor neuron and pancreas homeobox 1. (409 aa) |
| | TOX | Thymocyte selection associated high mobility group box. (527 aa) |
| | EPHB3 | EPH receptor B3. (997 aa) |
| | LHX6 | LIM homeobox 6. (392 aa) |
| | SPTBN4 | Spectrin beta, non-erythrocytic 4. (2615 aa) |
| | HSP90AA1 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (734 aa) |
| | CDK5 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neu [...] (292 aa) |
| | NFIB | Nuclear factor 1 B-type; Transcriptional activator of GFAP, essential for proper brain development. Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Belongs to the CTF/NF-I family. (561 aa) |
| | GBX2 | Gastrulation brain homeobox 2. (349 aa) |
| | OTP | Orthopedia homeobox. (325 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1274 aa) |
| | EPHA4 | EPH receptor A4. (986 aa) |
| | NKX2-2 | NK2 homeobox 2. (273 aa) |
| | DLL4 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa) |
| | ABT1 | Activator of basal transcription 1; Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity). (275 aa) |
| | FOXN4 | Forkhead box N4. (518 aa) |
| | DRD2 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (443 aa) |
| | GBX1 | Gastrulation brain homeobox 1. (406 aa) |
| | GBA2 | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (926 aa) |
| | NRP2 | Neuropilin; Belongs to the neuropilin family. (926 aa) |
| | TTLL1 | Probable tubulin polyglutamylase TTLL1; Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity). (423 aa) |
| | B4GALT5 | Beta-1,4-galactosyltransferase 5. (388 aa) |
| | CSF1R | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa) |
| | SMO | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa) |
| | SCYL2 | SCY1 like pseudokinase 2. (929 aa) |
| | NR2E1 | Nuclear receptor subfamily 2 group E member 1. (385 aa) |
| | DRAXIN | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (337 aa) |
| | PLXNA4 | Plexin A4. (1428 aa) |
| | KIFBP | KIF-binding protein; Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. (621 aa) |
| | CNTN2 | Contactin 2. (1040 aa) |
| | SCYL3 | SCY1 like pseudokinase 3. (734 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa) |
| | SEMA3E | Semaphorin 3E; Belongs to the semaphorin family. (775 aa) |
| | DMRT3 | Doublesex and mab-3 related transcription factor 3. (472 aa) |
| | NHLH2 | Nescient helix-loop-helix 2. (133 aa) |
| | CBLN1 | [des-Ser1]-cerebellin; Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber- Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses. Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post- synaptic components. On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part [...] (193 aa) |
| | DLX1 | Distal-less homeobox 1. (255 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | EPHB1 | EPH receptor B1. (984 aa) |
| | BTG2 | BTG anti-proliferation factor 2. (150 aa) |
| | POU3F4 | POU domain protein. (363 aa) |
| | TULP3 | Tubby-like protein; Belongs to the TUB family. (478 aa) |
| | HOXD10 | HOXD10 protein. (340 aa) |
| | ASCL1 | Achaete-scute family bHLH transcription factor 1. (219 aa) |
| | ISL2 | ISL LIM homeobox 2. (359 aa) |
| | UBB | Polyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (305 aa) |
| | ADARB1 | Adenosine deaminase RNA specific B1. (721 aa) |
| | TBX20 | T-box transcription factor 20. (449 aa) |
| | BCL11B | BAF chromatin remodeling complex subunit BCL11B. (904 aa) |
| | MAP2 | Microtubule-associated protein. (2008 aa) |
| | MYCBP2 | MYC binding protein 2. (4553 aa) |
| | PHOX2A | Paired like homeobox 2A. (284 aa) |
| | LHX8 | LIM homeobox 8. (377 aa) |
| | ZMIZ1 | Zinc finger MIZ-type containing 1. (1072 aa) |
| | EPHB2 | EPH receptor B2. (965 aa) |
| | FEZF2 | Fez family zinc finger protein 2; Transcription repressor. Binds to 5'GCAG-3' core sequence. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons (By similarity). May be responsible for mastitis resistance and innate immunity. (459 aa) |
| | TBR1 | T-box brain transcription factor 1. (682 aa) |
| | PLXNA3 | Plexin A3. (1897 aa) |
| | PLXNA1 | Plexin A1. (1929 aa) |
| | LBX1 | Ladybird homeobox 1. (282 aa) |
| | GLI3 | GLI family zinc finger 3. (1587 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa) |
| | PSEN1 | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (478 aa) |
| | SCYL1 | N-terminal kinase-like protein; Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro. (807 aa) |
| | CDH11 | Cadherin 11, type 2, OB-cadherin (Osteoblast); Cadherins are calcium-dependent cell adhesion proteins. (796 aa) |
| | DLX2 | Distal-less homeobox 2. (331 aa) |
| | SKOR2 | SKI family transcriptional corepressor 2. (1003 aa) |
| | GSX1 | Uncharacterized protein. (163 aa) |
| | LHX1 | LIM homeobox 1. (406 aa) |
| | FBXO45 | F-box protein 45. (281 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (346 aa) |
| | LHX3 | LIM homeodomain 3 protein b isoform. (403 aa) |
| | GDF7 | Growth differentiation factor 7. (450 aa) |
| | PHOX2B | Paired like homeobox 2B. (315 aa) |
| | ZNF335 | Zinc finger protein 335. (1346 aa) |
| | SLIT2 | Slit guidance ligand 2. (1534 aa) |
| | NTRK2 | Tyrosine-protein kinase receptor. (837 aa) |
| | B4GALT6 | Beta-1,4-galactosyltransferase 6. (382 aa) |
| | DCLK1 | Doublecortin like kinase 1; Belongs to the protein kinase superfamily. (423 aa) |
| | OLIG3 | Oligodendrocyte transcription factor 3. (272 aa) |
| | GRID2 | Glutamate ionotropic receptor delta type subunit 2. (922 aa) |
| | PTCH1 | SSD domain-containing protein. (1453 aa) |
| | TCTN1 | Tectonic family member 1. (588 aa) |
| | GSX2 | GS homeobox 2. (305 aa) |
| | INHBA | Inhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (425 aa) |
| | RAPGEF2 | Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...] (1648 aa) |
| | PROX1 | Prospero homeobox 1. (737 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | HES1 | Transcription factor HES-1; Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'- CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). (280 aa) |
| | POU4F1 | POU domain protein. (421 aa) |
| | LMX1A | LIM homeobox transcription factor 1 alpha. (382 aa) |
| | NIN | Ninein. (2167 aa) |
| | OGDH | 2-oxoglutarate dehydrogenase, mitochondrial; 2-oxoglutarate dehydrogenase (E1) component of the 2- oxoglutarate dehydrogenase complex, which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl- Co [...] (1038 aa) |
| | HSP90AB1 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (724 aa) |
| | RORA | RAR related orphan receptor A. (527 aa) |
| | PEX5 | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. (640 aa) |
| | SUFU | Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa) |
| | CLN8 | TLC domain-containing protein. (278 aa) |
| | ELAVL4 | ELAV-like protein; Belongs to the RRM elav family. (371 aa) |
| | NKX2-1 | NK2 homeobox 1. (408 aa) |
| | FOXG1 | Forkhead box G1. (490 aa) |
| | PAFAH1B1 | Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa) |
| | RAC3 | Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...] (192 aa) |
| | ARX | Aristaless related homeobox. (560 aa) |
| | DCC | DCC netrin 1 receptor. (1394 aa) |
| | OPHN1 | Oligophrenin 1. (803 aa) |
| | ARHGAP35 | Rho GTPase activating protein 35. (1500 aa) |
| | SPOCK1 | Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (Testican) 1. (442 aa) |
| | AGTPBP1 | ATP/GTP binding protein 1. (1181 aa) |
| | SPG11 | SPG11 vesicle trafficking associated, spatacsin. (2467 aa) |
| | SLC4A10 | Sodium-driven chloride bicarbonate exchanger; Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (By similarity). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (By similarity). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similar [...] (1117 aa) |
| | HOXC10 | Homeobox C10. (373 aa) |
| | FAIM2 | Protein lifeguard 2; Antiapoptotic protein which protects cells uniquely from Fas- induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development (By similarity). (316 aa) |
| | PAX6 | Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity); Belongs to the paired homeobox family. (436 aa) |
| | LDB1 | LIM domain binding 1. (392 aa) |
