Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APP | CD4 | ENSBTAP00000060984 | ENSBTAP00000037566 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | CD4 molecule. | 0.434 |
| APP | IFNG | ENSBTAP00000060984 | ENSBTAP00000016634 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.569 |
| APP | SIRT1 | ENSBTAP00000060984 | ENSBTAP00000018630 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Sirtuin 1. | 0.498 |
| BMP4 | CSF1 | ENSBTAP00000004992 | ENSBTAP00000057942 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | 0.418 |
| BMP4 | VEGFA | ENSBTAP00000004992 | ENSBTAP00000055683 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] | 0.435 |
| CASP8 | CD4 | ENSBTAP00000062824 | ENSBTAP00000037566 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | CD4 molecule. | 0.585 |
| CASP8 | CSF2 | ENSBTAP00000062824 | ENSBTAP00000002054 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | 0.419 |
| CASP8 | IFNG | ENSBTAP00000062824 | ENSBTAP00000016634 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.660 |
| CASP8 | SIRT1 | ENSBTAP00000062824 | ENSBTAP00000018630 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | Sirtuin 1. | 0.432 |
| CD4 | APP | ENSBTAP00000037566 | ENSBTAP00000060984 | CD4 molecule. | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.434 |
| CD4 | CASP8 | ENSBTAP00000037566 | ENSBTAP00000062824 | CD4 molecule. | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | 0.585 |
| CD4 | CSF1 | ENSBTAP00000037566 | ENSBTAP00000057942 | CD4 molecule. | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | 0.690 |
| CD4 | CSF2 | ENSBTAP00000037566 | ENSBTAP00000002054 | CD4 molecule. | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | 0.908 |
| CD4 | IFNG | ENSBTAP00000037566 | ENSBTAP00000016634 | CD4 molecule. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.955 |
| CD4 | IL15 | ENSBTAP00000037566 | ENSBTAP00000059902 | CD4 molecule. | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. | 0.877 |
| CD4 | SIRT1 | ENSBTAP00000037566 | ENSBTAP00000018630 | CD4 molecule. | Sirtuin 1. | 0.434 |
| CD4 | SOCS1 | ENSBTAP00000037566 | ENSBTAP00000005753 | CD4 molecule. | Suppressor of cytokine signaling 1. | 0.630 |
| CD4 | SPI1 | ENSBTAP00000037566 | ENSBTAP00000028937 | CD4 molecule. | Spi-1 proto-oncogene. | 0.477 |
| CD4 | TSPAN2 | ENSBTAP00000037566 | ENSBTAP00000074560 | CD4 molecule. | Tetraspanin. | 0.515 |
| CEBPE | SIRT1 | ENSBTAP00000007811 | ENSBTAP00000018630 | CCAAT/enhancer-binding protein. | Sirtuin 1. | 0.450 |
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