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| | PTEN | Phosphatase and tensin homolog. (573 aa) |
| | ASB12-2 | Myotubularin related protein 8. (690 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (559 aa) |
| | HAO2 | Hydroxyacid oxidase 2; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. (353 aa) |
| | MBOAT4 | Membrane bound O-acyltransferase domain containing 4; Belongs to the membrane-bound acyltransferase family. (435 aa) |
| | INPP5E | Inositol polyphosphate-5-phosphatase E. (656 aa) |
| | HADH | Hydroxyacyl-CoA dehydrogenase. (314 aa) |
| | CYP4V2 | Uncharacterized protein; Belongs to the cytochrome P450 family. (527 aa) |
| | BDH2 | 3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria (By similarity). Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). (245 aa) |
| | PIP4P1 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (277 aa) |
| | CYP24A1 | Uncharacterized protein. (447 aa) |
| | ACAT2 | Acetyl-Coenzyme A acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa) |
| | ADH4 | PKS_ER domain-containing protein. (380 aa) |
| | ECHDC2 | Enoyl-CoA hydratase domain-containing protein 2, mitochondrial. (346 aa) |
| | ACADVL | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial; Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, myristoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons; Belongs to the acyl-CoA dehydrogenase family. (655 aa) |
| | PLPPR1 | Phospholipid phosphatase related 1. (325 aa) |
| | SACM1L | Phosphatidylinositide phosphatase SAC1; Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (By similarity). Has low activity towards PtdIns(3,5)P2 (By similarity). (587 aa) |
| | HACL1 | 2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family. (581 aa) |
| | MTMR9 | Myotubularin-related protein 9; Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate, and MTMR6 binding affinity for phosphorylated phosphatidylinositols (By similarity). Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity). Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels. Stabilizes MTMR8 protein levels. Plays a role in the la [...] (549 aa) |
| | SCP2 | Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. (543 aa) |
| | PEX2 | Peroxisomal biogenesis factor 2. (305 aa) |
| | ACOX2 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (682 aa) |
| | SGPP1 | Sphingosine-1-phosphate phosphatase 1. (445 aa) |
| | DGKE | Diacylglycerol kinase. (564 aa) |
| | B4GALNT1 | Beta-1,4 N-acetylgalactosaminyltransferase. (533 aa) |
| | PLPPR5 | Phospholipid phosphatase related 5. (321 aa) |
| | PEX13 | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins (By similarity). (403 aa) |
| | SOAT2 | O-acyltransferase. (535 aa) |
| | FIG4 | FIG4 phosphoinositide 5-phosphatase. (907 aa) |
| | SLC25A17 | Solute carrier family 25 (Mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa) |
| | ALDH1L2 | 10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (923 aa) |
| | HSD17B4 | Hydroxysteroid (17-beta) dehydrogenase 4. (736 aa) |
| | PHYH | Phytanoyl-CoA dioxygenase, peroxisomal; Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. (337 aa) |
| | MBOAT2 | Membrane bound O-acyltransferase domain containing 2; Belongs to the membrane-bound acyltransferase family. (526 aa) |
| | SPHK1 | Sphingosine kinase 1. (489 aa) |
| | ALOX15B | Arachidonate 15-lipoxygenase type B. (677 aa) |
| | INPP5A | Inositol polyphosphate-5-phosphatase A. (412 aa) |
| | CERKL | Ceramide kinase like. (541 aa) |
| | PORCN | Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (450 aa) |
| | LOC527409 | Similar to glycoprotein galactosyltransferase alpha 1, 3. (333 aa) |
| | MTMR1 | Myotubularin related protein 1. (684 aa) |
| | B4GALNT2 | Beta-1,4-N-acetyl-galactosaminyltransferase 2. (488 aa) |
| | ECI1 | Enoyl-CoA delta isomerase 1. (303 aa) |
| | ACADL | Acyl-Coenzyme A dehydrogenase, long chain. (430 aa) |
| | PLPP6 | Phospholipid phosphatase 6; Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid (By similarity). Belongs to the PA-phosphatase related phosphoesterase family. (289 aa) |
| | GBA2 | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (926 aa) |
| | INPP5K | Inositol polyphosphate-5-phosphatase K. (416 aa) |
| | PLPP3 | Phospholipid phosphatase 3; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z- octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of the [...] (311 aa) |
| | ALOX15 | Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12- HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the o [...] (663 aa) |
| | FA2H | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa) |
| | ALOX12B | Arachidonate 12-lipoxygenase, 12R type. (699 aa) |
| | ETFA | Electron transfer flavoprotein subunit alpha, mitochondrial; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. (333 aa) |
| | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial; This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. Belongs to the thiolase-l [...] (422 aa) |
| | PIK3C2B | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa) |
| | DGKZ | Diacylglycerol kinase. (1145 aa) |
| | DGKH | Diacylglycerol kinase. (509 aa) |
| | MTMR9-2 | Myotubularin-related protein 9-like; Probable pseudophosphatase. (543 aa) |
| | ABCD4 | ATP binding cassette subfamily D member 4. (606 aa) |
| | CPT2 | Carnitine O-palmitoyltransferase 2, mitochondrial; Belongs to the carnitine/choline acetyltransferase family. (658 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa) |
| | ILVBL | Acetolactate synthase-like protein. (639 aa) |
| | EPHX2 | Epoxide hydrolase 2. (555 aa) |
| | MBOAT7 | Lysophospholipid acyltransferase 7; Acyltransferase which contributes to the regulation of free arachidonic acid (AA) in the cell through the remodeling of phospholipids. Mediates the conversion of lysophosphatidylinositol (1- acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2- diacyl-sn-glycero-3-phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor (By similarity). Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (By similarity). Required for [...] (472 aa) |
| | ADH5 | Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (374 aa) |
| | CPT1B | Carnitine O-palmitoyltransferase 1, muscle isoform. (771 aa) |
| | MBOAT1 | Membrane bound O-acyltransferase domain containing 1; Belongs to the membrane-bound acyltransferase family. (490 aa) |
| | PEX7 | Peroxisomal biogenesis factor 7. (323 aa) |
| | INPP5J | Inositol polyphosphate-5-phosphatase J. (1028 aa) |
| | DGKQ | Diacylglycerol kinase. (942 aa) |
| | HSD17B10 | 3-hydroxyacyl-CoA dehydrogenase type-2; Mitochondrial dehydrogenase that catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha- hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20- beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). Essential for structura [...] (261 aa) |
| | LCAT | Lecithin-cholesterol acyltransferase. (440 aa) |
| | OCRL | OCRL inositol polyphosphate-5-phosphatase. (876 aa) |
| | ACAA1 | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (424 aa) |
| | CYP2E1 | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. (509 aa) |
| | PLPPR4 | Phospholipid phosphatase related 4. (716 aa) |
| | INPPL1 | Inositol polyphosphate phosphatase like 1. (1264 aa) |
| | ENSBTAP00000073808 | Uncharacterized protein. (481 aa) |
| | ST3GAL4 | ST3 beta-galactoside alpha-2,3-sialyltransferase 4; Belongs to the glycosyltransferase 29 family. (395 aa) |
| | ECHS1 | Enoyl-CoA hydratase, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (By similarity). Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family. (341 aa) |
| | MTMR2 | Myotubularin-related protein 2; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3- phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity). Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5- phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Stabilizes SBF2/MTMR13 at the membranes. Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein (By similarity). (643 aa) |
| | DGKD | Diacylglycerol kinase. (1234 aa) |
| | SYNJ1 | Synaptojanin-1; Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)- bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2. Belongs to the synaptojanin family. (1579 aa) |
| | ENSBTAP00000071610 | Acyl-CoA_dh_1 domain-containing protein. (216 aa) |
| | PEX5 | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. (640 aa) |
| | MTMR11 | Myotubularin related protein 11. (698 aa) |
| | PLPP1 | Phospholipid phosphatase 1. (286 aa) |
| | HADHB | Trifunctional enzyme subunit beta, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enz [...] (486 aa) |
| | SLC35C1 | GDP-fucose transporter 1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen; Belongs to the TPT transporter family. SLC35C subfamily. (364 aa) |
| | ACOX1 | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl- CoAs. (660 aa) |
| | ENSBTAP00000070244 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (372 aa) |
| | PLA2G7 | Platelet-activating factor acetylhydrolase; Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids; Belongs to the AB hydrolase superfamily. Lipase family. (444 aa) |
| | DECR1 | 2,4-dienoyl-CoA reductase 1. (329 aa) |
| | GLT6D1 | Glycosyltransferase 6 domain-containing protein 1; Belongs to the glycosyltransferase 6 family. (308 aa) |
| | ALOX5 | Arachidonate 5-lipoxygenase. (674 aa) |
| | ABCD1 | ATP-binding cassette, sub-family D (ALD), member 1. (737 aa) |
| | PIP4P2 | Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5- monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylino [...] (257 aa) |
| | CROT | Peroxisomal carnitine O-octanoyltransferase; Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate; Belongs to the carnitine/choline acetyltransferase family. (616 aa) |
| | INPP5F | Inositol polyphosphate-5-phosphatase F. (1133 aa) |
| | ALOX12 | Arachidonate 12-lipoxygenase, 12S type. (663 aa) |
| | DGKK | Diacylglycerol kinase. (1226 aa) |
| | INPP5B | Inositol polyphosphate-5-phosphatase B. (975 aa) |
| | ACADM | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). (421 aa) |
| | ABCD3 | ATP binding cassette subfamily D member 3. (656 aa) |
| | SOAT1 | O-acyltransferase. (551 aa) |
| | SYNJ2 | Synaptojanin 2. (1487 aa) |
| | PLPP5 | Phospholipid phosphatase 5. (264 aa) |
| | ADIPOR1 | Adiponectin receptor 1. (375 aa) |
| | ACOX3 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (700 aa) |
| | ALOX12E | ALOX12E protein. (633 aa) |
| | PLPP4 | Phospholipid phosphatase 4. (271 aa) |
| | ACAA2 | 3-ketoacyl-CoA thiolase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. (455 aa) |
| | AGK | Acylglycerol kinase. (421 aa) |
| | HADHA | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (771 aa) |
| | ENSBTAP00000068994 | Uncharacterized protein. (193 aa) |
| | A3GALT2 | Uncharacterized protein. (233 aa) |
| | PLPPR3 | Phospholipid phosphatase related 3. (728 aa) |
| | ENSBTAP00000068106 | acidPPc domain-containing protein. (229 aa) |
| | C1QTNF9 | Complement C1q and tumor necrosis factor-related protein 9. (357 aa) |
| | ACAD10 | Uncharacterized protein. (1098 aa) |
| | SPHK2 | Sphingosine kinase 2. (713 aa) |
| | AUH | Uncharacterized protein. (275 aa) |
| | ST3GAL2 | ST3 beta-galactoside alpha-2,3-sialyltransferase 2; Belongs to the glycosyltransferase 29 family. (350 aa) |
| | ABO | ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase. (375 aa) |
| | CPT1C | Carnitine palmitoyltransferase 1C. (811 aa) |
| | MTM1 | Myotubularin; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not fo [...] (603 aa) |
| | GGTA1 | N-acetyllactosaminide alpha-1,3-galactosyltransferase; Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Preferentially glycosylates proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isoglobotrihexosylceramide or isogloboside 3 (iGb3). Belongs to the glycosyltransferase 6 family. (495 aa) |
| | ADIPOQ | Adiponectin; Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis [...] (328 aa) |
| | DGKI | Diacylglycerol kinase. (1044 aa) |
| | LOC513508 | Uncharacterized protein. (847 aa) |
| | SLC27A2 | Solute carrier family 27 member 2. (633 aa) |
| | ENSBTAP00000063081 | Uncharacterized protein. (313 aa) |
| | DGKG | Diacylglycerol kinase. (799 aa) |
| | MTMR6 | Myotubularin related protein 6. (630 aa) |
| | SAMD1 | Chromosome 7 C19orf67 homolog. (535 aa) |
| | SGPP2 | Sphingosine-1-phosphate phosphatase 2. (414 aa) |
| | DGKA | Diacylglycerol kinase alpha; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. (734 aa) |
| | CRAT | Carnitine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (626 aa) |
| | GBA | Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] (536 aa) |
| | PLPP2 | Phospholipid phosphatase 2; Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Has no apparent extracellular phosphatase activity and therefore most probably acts intracellularly. Also acts on N-oleoyl ethanolamine phosphate/N- (9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Through dephosphorylation of these bioactive lipid mediators produces new bioacti [...] (298 aa) |
| | ECH1 | Enoyl-CoA hydratase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (326 aa) |
| | ACOXL | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (631 aa) |
| | INPP5D | Inositol polyphosphate-5-phosphatase D. (1319 aa) |
| | GCDH | Glutaryl-CoA dehydrogenase, mitochondrial; Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L- hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor (By similarity). (458 aa) |
| | MTMR10 | Myotubularin related protein 10. (778 aa) |
| | MTMR4 | Myotubularin related protein 4. (1211 aa) |
| | MTMR3 | Myotubularin related protein 3. (1214 aa) |
| | ACADS | Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogen [...] (438 aa) |
| | CPT1A | Carnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa) |
| | PPARD | Peroxisome proliferator activated receptor delta. (441 aa) |
| | GBGT1 | Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1. (378 aa) |
| | ETFDH | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; Accepts electrons from ETF and reduces ubiquinone. Belongs to the ETF-QO/FixC family. (873 aa) |
| | PLPPR2 | Phospholipid phosphatase-related protein type 2; Belongs to the PA-phosphatase related phosphoesterase family. (452 aa) |
| | ECHDC1 | Ethylmalonyl-CoA decarboxylase; Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level; Belongs to the enoyl-CoA hydratase/isomerase family. (306 aa) |
| | LOC100300115 | Uncharacterized protein. (333 aa) |
| | CERK | Ceramide kinase. (535 aa) |
| | HAO1 | Hydroxyacid oxidase 1. (387 aa) |
| | MTMR12 | Myotubularin related protein 12. (776 aa) |
| | CYP1A1 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (516 aa) |
| | EHHADH | Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase. (723 aa) |
| | DGKB | Diacylglycerol kinase. (803 aa) |
| | LPCAT3 | Lysophospholipid acyltransferase 5; Seems to be the major enzyme contributing to lysophosphatidylcholine acyltransferase activity in the liver. Favors unsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Displays lysophosphatidylserine acyltransferase (LPSAT) activity (By similarity). (485 aa) |
| | E1B8Y5_BOVIN | Uncharacterized protein. (283 aa) |
| | ABCD2 | ATP binding cassette subfamily D member 2. (741 aa) |
| | ACAD11 | Acyl-Coenzyme A dehydrogenase family, member 11. (781 aa) |
| | MTMR7 | Myotubularin related protein 7. (660 aa) |
