STRINGSTRING
CNBD2 CNBD2 PRKAR1A PRKAR1A PDE4A PDE4A POPDC2 POPDC2 CNGA2 CNGA2 PDE4B PDE4B CNGB1 CNGB1 HCN1 HCN1 RAPGEF4 RAPGEF4 POPDC3 POPDC3 RAPGEF2 RAPGEF2 BVES BVES PDE10A PDE10A PDE2A PDE2A PDE4D PDE4D ENSBTAP00000067978 ENSBTAP00000067978 PRKAR1B PRKAR1B PRKAR2A PRKAR2A PRKAR2B PRKAR2B MAP2 MAP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CNBD2Cyclic nucleotide binding domain containing 2. (569 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. (380 aa)
PDE4APhosphodiesterase. (872 aa)
POPDC2Popeye domain containing 2. (368 aa)
CNGA2Cyclic nucleotide-gated olfactory channel; Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily. (663 aa)
PDE4BPhosphodiesterase. (721 aa)
CNGB1Cyclic nucleotide-gated cation channel beta-1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP (By similarity). (952 aa)
HCN1Hyperpolarization activated cyclic nucleotide gated potassium channel 1. (877 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
POPDC3Popeye domain containing 3. (291 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...] (1648 aa)
BVESBlood vessel epicardial substance. (360 aa)
PDE10APhosphodiesterase. (763 aa)
PDE2AcGMP-dependent 3',5'-cyclic phosphodiesterase; Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. (1015 aa)
PDE4DPhosphodiesterase. (678 aa)
ENSBTAP00000067978Uncharacterized protein. (85 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (548 aa)
PRKAR2AcAMP-dependent protein kinase type II-alpha regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase (By similarity). (401 aa)
PRKAR2BcAMP-dependent protein kinase type II-beta regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. (418 aa)
MAP2Microtubule-associated protein. (2008 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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