STRINGSTRING
PRKCH PRKCH BMP4 BMP4 VEZF1 VEZF1 GDF2 GDF2 BMP2 BMP2 GDNF GDNF FGF2 FGF2 TP73 TP73 ETV4 ETV4 ALOX15B ALOX15B SFN SFN VDR VDR TMEM100 TMEM100 NKX2-2 NKX2-2 BAD BAD NOTCH1 NOTCH1 ETV2 ETV2 PROM1 PROM1 ACVRL1 ACVRL1 WNT10B WNT10B SFRP4 SFRP4 H2AFY H2AFY CTNNB1 CTNNB1 CYP27B1 CYP27B1 NUMA1 NUMA1 BMP6 BMP6 ATOH8 ATOH8 PTCH2 PTCH2 NME2 NME2 LHX1 LHX1 MED1 MED1 BMP7 BMP7 PTCH1 PTCH1 SULT2B1 SULT2B1 ZBED2 ZBED2 PAX4 PAX4 FOXJ1 FOXJ1 KDF1 KDF1 H2AFY2 H2AFY2 BTG1 BTG1 PAX6 PAX6 MESP1 MESP1 NCOA3 NCOA3 FOXN1 FOXN1 SOX9 SOX9 LIF LIF AHI1 AHI1 TRIM16 TRIM16 ATOH1 ATOH1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
VEZF1Vascular endothelial zinc finger 1. (508 aa)
GDF2Growth differentiation factor 2. (431 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
FGF2Kidney-derived growth factor; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (640 aa)
ETV4ETS variant 4. (485 aa)
ALOX15BArachidonate 15-lipoxygenase type B. (677 aa)
SFN14-3-3 protein sigma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (By similarity). (248 aa)
VDRVitamin D3 receptor; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity). Belongs to the nuclear hormone receptor family. NR1 subfamily. (425 aa)
TMEM100Transmembrane protein 100; Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor- dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open [...] (134 aa)
NKX2-2NK2 homeobox 2. (273 aa)
BADBCL2 associated agonist of cell death. (168 aa)
NOTCH1Notch receptor 1. (2533 aa)
ETV2ETS variant 2. (332 aa)
PROM1Prominin 1. (864 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
SFRP4Secreted frizzled-related protein 4. (346 aa)
H2AFYCore histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (371 aa)
CTNNB1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] (781 aa)
CYP27B1Uncharacterized protein; Belongs to the cytochrome P450 family. (508 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2095 aa)
BMP6Bone morphogenetic protein 6. (496 aa)
ATOH8Atonal bHLH transcription factor 8. (317 aa)
PTCH2Patched 2. (1156 aa)
NME2Nucleoside diphosphate kinase B; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE I [...] (152 aa)
LHX1LIM homeobox 1. (406 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1575 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PTCH1SSD domain-containing protein. (1453 aa)
SULT2B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (338 aa)
ZBED2Zinc finger BED-type containing 2. (217 aa)
PAX4Paired box 4. (368 aa)
FOXJ1Forkhead box J1. (421 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
H2AFY2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
BTG1Protein BTG1; Anti-proliferative protein; Belongs to the BTG family. (378 aa)
PAX6Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity); Belongs to the paired homeobox family. (436 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (274 aa)
NCOA3Nuclear receptor coactivator. (1411 aa)
FOXN1Forkhead box N1. (644 aa)
SOX9SRY-box transcription factor 9. (524 aa)
LIFLeukemia inhibitory factor; LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes (By similarity); Belongs to the LIF/OSM family. (300 aa)
AHI1Abelson helper integration site 1. (1172 aa)
TRIM16Uncharacterized protein. (562 aa)
ATOH1Atonal bHLH transcription factor 1. (352 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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