STRINGSTRING
IFT81 IFT81 UBXN10 UBXN10 TRAF3IP1 TRAF3IP1 IFT80 IFT80 TTC26 TTC26 TTC30A TTC30A IFT27 IFT27 IFT74 IFT74 IFT172 IFT172 TTC30B TTC30B IFT46 IFT46 IFT20 IFT20 IFT57 IFT57 HSPB11 HSPB11 IFT88 IFT88 ENSBTAP00000072807 ENSBTAP00000072807 IFT22-2 IFT22-2 IFT22 IFT22 CLUAP1 CLUAP1 IFT52 IFT52
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFT81Intraflagellar transport 81. (698 aa)
UBXN10UBX domain protein 10. (281 aa)
TRAF3IP1TRAF3 interacting protein 1. (686 aa)
IFT80Intraflagellar transport 80. (760 aa)
TTC26Tetratricopeptide repeat domain 26. (554 aa)
TTC30ATetratricopeptide repeat protein 30A; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip; Belongs to the TTC30/dfy-1/fleer family. (664 aa)
IFT27Intraflagellar transport protein 27 homolog; Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6. Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6. Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a rol [...] (186 aa)
IFT74Intraflagellar transport 74. (600 aa)
IFT172Intraflagellar transport 172. (421 aa)
TTC30BTetratricopeptide repeat protein 30B; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip; Belongs to the TTC30/dfy-1/fleer family. (664 aa)
IFT46Intraflagellar transport protein 46 homolog; Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity). (301 aa)
IFT20Intraflagellar transport protein 20 homolog; Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling. Essential for male fertility. Plays an important role in spermatogenesis, particularly sperm [...] (156 aa)
IFT57Intraflagellar transport protein 57 homolog; Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear (By similarity). (429 aa)
HSPB11Heat shock protein family B (small) member 11. (143 aa)
IFT88Intraflagellar transport 88. (850 aa)
ENSBTAP00000072807Uncharacterized protein. (166 aa)
IFT22-2Intraflagellar transport protein 22 homolog; Small GTPase-like component of the intraflagellar transport (IFT) complex B; Belongs to the small GTPase superfamily. Rab family. (217 aa)
IFT22Intraflagellar transport protein 22 homolog. (199 aa)
CLUAP1Clusterin associated protein 1. (457 aa)
IFT52Intraflagellar transport 52 homolog (Chlamydomonas). (440 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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